Final Flashcards
Schizophrenia
- a neurodevelopmental disorder of the brain- expressed in abnormal mental functions and disturbed behaviour
- characterized by severe psychotic symptoms, bizarre delusions, hallucinations, thought disturbances, grossly disorganized behaviour or catatonic behaviour, extremely inappropriate or flat affect, and significant deterioration or impairment in functioning
Child onset schizophrenia (COS)
- rarer and possibly more severe (but not distinct) form of schizophrenia
- occurs during childhood
- gradual, rather than sudden onset
- likely to persist into adolescence and adulthood
- has profound negative impact on developing social and academic competence
Positive symptoms
- things that are there/ added
- delusions (beliefs)
- hallucinations (most common auditory- occurs in 80%)
Negative symptoms
- loss of function
- slowed thinking, speech, movement; emotional apathy; lack of drive; indifference to social contact; self- neglect
- can be very persistent and difficult to treat
- difficult to recognize
DSM-5 diagnostic criteria schizophrenia
A) severe disturbance in sensory functioning and/ or behaviour (2+) (at least one delusions, hallucinations, or disorganized speech)
B) social/ occupational dysfunction
C) duration 6+months with at least one month of symptoms that meet criteria D) Schizoaffective and mood disorder exclusion
E) substance/ medical condition exclusion
F) relationship to autism spectrum disorder or communication disorder- schizophrenia only diagnosed if delusions and hallucinations present for one month
Other times psychotic symptoms can occur
- depression
- bipolar disorder
- substance abuse
Precursors childhood onset schizophrenia
- gradual onset
- almost 95% have history of behavioural, social, and psychiatric disturbances before onset of psychosis
- developmental precursors
Comorbidities childhood onset schizophrenia
- 70% meet criteria for another diagnosis
- most commonly mild disorder or ODD/ CD
- number links between COS and ASD
- one study found that COS preceded ASD in 30-50% cases (both deficits in TOM, accelerated brian development near onset of disorder, similar abnormalities in rural connectivity)
Prevalence COS
- extremely rare (1/10,000)
- dramatic increase adolescence, model onset around 22 years of age
- COS earlier onset in boys by 2-4 years (gender differences disappear in adolescence)
- most psychotic diagnosis onset I. Late adolescents/ early adulthood (peak 15-25 males, 20-29 females)
- prodromal period thought to precede psychotic diagnosis by 1-6 years
Potential problems in assessment COS?
- screening measures developed for adolescents and young adults
- children responses to these measures need to be Interpeted with caution
- children’s questionarire endorsement of hallucinations
- delusions and persecutory ideas also found common in childhood
Neurodevelopmental model causes of COS
- genetic vulnerability and early neurodevelopmental insults result in impaired connections between many brian regions
- defective neural circuitry increases a child’s vulnerability to stress
Biological factors for causes of COS
- strong genetic contribution (several potential susceptibility genes)
- best represented by continuum of risk with many GxE interactions
- CNS dysfunction and improvements with medication suggest it is a disorder of the brain (enlarged ventricles, grey matter shrinkage, and other structural differences)
- widespread developmental disruption of neural connectivity
Environmental factors causes of COS
- familial disorder and no genetic factors may place a role trough interaction with a genetic susceptibility
- do not alone cause schizophrenia
- high communication deviance
- stress, distress and personal trashed experienced by families and children with schizophrenia
Treatment of COS
- chronic disorder with poor long- term prognosis
- antipsychotic medications (block dopamine transmission but serious side effects) combined with psychotherapy and social and educational support programs
Mood disorders
- run spectrum grime severe depression to extreme mania and involve extreme, persistent, or poorly regulated mood states
DSM-5 divides mood disorder into Eros general categories:
- depressive disorders and
- bipolar disorders
Depressive disorders
- excessive unhappiness (dysphoria) and loss of interest in activities (anhedonia), irritability
Bipolar disorder
- mood swings from deep sadness to high elation (euphoria) and expansive mood (mania)
Major Depressive Disorder DSM-5 criteria
A. 5 or more present during same 2 week period: depressed mood, diminished interest/ pleasure, weight & appetitie, insomnia/ hypersomnia, psychomotor agitation/ retardation, fatigue/ loss of energy, feelings or worthlessness/ excessive guilt, diminished ability to think/ concentrate or indecisiveness, recurrent thoughts of death/ suicidal ideation
B. Distress/ impairment
C. Not due to substance or another medical condition
D. Not better explained by another psychiatric disorder
E. Has never been a manic or hypermanic episode
Depression and development
- experience/ expression of depression changes with age
Children under 7 (as young as 3-5) depression
- less easily identified
- anaclitic depression (spitz)- infants raised in clean but emotionally cold institutional environment displayed reactions resembling depression, sometimes resulting in death (similar symptoms can occur in infants raised in severely disturbed families)
Preschoolers depression
- somber/ tearful
- lack enthusiasm
- excessive clinging/ whiny behaviour around others
- separation/ abandonment fears
- irritability, physical complaints
School-aged children depression
- increased irritability, disruptive behaviours, tantrums, combativeness
- physical complaints (et loss, headaches, sleep)
- suicide threats begin
Preteens depression
- self- blame and low self- esteem
- persistent sadness
- social inhibition
- sleep/ eating disturbances
Compared to younger children adolescents (depression):
- more likely to report hopelessness
- predictors of depression may differ: negative life events (younger) vs pessimistic attributions style (older)
- more reporting low self esteem
- more neurovegetative symptoms
- more suicidal ideation, attempts
- diurnal variation
- social withdrawal
- girls (negative body image, weight- appetite disturbance, worthlessness/ guilt)
Depression as a symptom
- feeling sad or miserable
- occurs without existence if serious problem and is common at all ages
Depression as a syndrome
- a group of symptoms that occur together more often than by chance
- sadness, reduced interest, cognitive and motivational changes, somatic, psychomotor changes
- mixed symptoms of anxiety and depression that tend to cluster on A single dimension of negative affect
Depression as a disorder
- MDD
- persistent depressive disorder (P-DD) or dysthymia
- disruptive mood disregulation disorder (DMDD)
Major Depressive disorder (MDD)
- minimum duration of two weeks; associated with depressed mood, loss of interest, other symptoms, and significant impairment in functioning
Persistent Depressive disorder (P-DD) or dysthymia
- depressed mood, generally less severe but longer lasting symptoms ( a year or more), and significant impairment in functioning
Disruptive mood dysregulation disorder (DMDD)
- frequent and severe temper outbursts that are extreme over- reactions to situation
- chronic, persistently irritable or angry mood present.l between severe temper outbursts
Prevalence MDD
- rate preschool and school age increased two- three fold by adolescence
- modest increase from preschool to elementary school
- sharp increase in adolescence
Comorbidity depression
- ~90% have one or more other disorders
- most common anxiety disorders (especially GAD), specific phobia, separation anxiety disorder
- others dysthymia, conduct problems, ADHD, eating disorders and substance use disorders
- personality disorders
Onset course and outcome depression
- gradual or sudden (usually history of milder episodes that do not meet diagnostic criteria)
- age onset 13-15 years
- average episode 8 months, most recover (linger if parent has depression)
- high chance recurrence
- 1/3 bipolar switch (develop bipolar disorder after being diagnosed with depression)
- overall outcome not optimistic (continue high risk for later episodes of mood and other disorders $ children often continue to experience adjustment and health problems and chronic stress)
Gender depression
- before adolescence approx equal
- after puberty females 2-3x that if males
- symptoms generally similar, but some differences
Persistent Depressive Disorder (P-DD)
- characterized. T symptoms of depressed mood that occur in most days, and persist for at least one year, with 2 or more of: eating, sleeping, energy, low self esteem, poor concentration difficulty making decisions, and feelings of hopelessness
- less severe symptoms but more chronic than MDD
- prevalence rates lower than MDD
- most comirbid disorder is MDD
P-DD onset, course, and outcomes
- common age onset 11-12 years
- childhood indent leads to prolonged duration
- may be precursor to MDD for some children
- most recover but high risk for developing other disorders especially MDD, anxiety disorders, and conduct disorders
- increased risk for bipolar disorder and substance use disorder
- receive less social support than those with MDD
Associated characteristics of Depressive disorders
- intellectual and academic functioning
- social and peer problems: can lead to socially helpless behaviour or aggressive behaviour which both lead to neglect
- family problems (less supportive/ more conflicted, feel socially isolated and prefer to be alone)
- negative self esteem
- congnitice biases and disturbances