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Med Chem > Final > Flashcards

Final Flashcards

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1
Q

Drug examples for Urinary Excretion

A

Vancomycin
Atenolol
Ampicillin

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2
Q

Affect Renal Excretion

A 
Kidney Disease
Glomerular Filtration Rate
Back Diffusion
Active Tubular Secretion
Tubular pH
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3
Q

Drug examples for dose adjustment for Chronic Kidney Disease

A

Aminoglycoside antibiotics

Cephalosporin Antibiotics

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4
Q

Active Transports for Tubular Secretion and Reabsorption

A

OATPs
POTs
PGPs
MRP2

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5
Q

Drug examples for Bile/Feces elimination

A

Digoxin
Steroids (prednisone)
Hydrophobic Anticancer

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6
Q

Affects Biliary/Fecal Excretion

A

Cholestasis (reduces bile flow)

Enterohepatic recirculation

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7
Q

Active Transports for Biliary/Fecal Excretion

A

OATPs
BCRP
PGP
MDR/MRP

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8
Q

Drug Examples that undergo Enterohepatic Recirculation

A

Zetia
Isotretinoin
Atovaquone

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9
Q

Clinically Disrupting Enterohepatic Recirculation

A

Activated Charcoal

Anion Exchange Resins

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10
Q

Breast milk drug transporter

A

BCRP

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11
Q

Drug examples in breast milk

A

Topotecan

Cimetidine

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12
Q

DME related toxicity depends on

A

Tissue expression of DME
Presence of deactivating DMEs and cofactors
Cellular structures to react with
Reactive metabolites ability to access toxicity site

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13
Q

Risk Factors for Drug-Induced Hepatotoxicity

A 
Ethnicity
Genetics
Age
Gender
Alcohol
Liver Disease
Kinetics/Dynamics
Herbals
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14
Q

Ethanol Metabolism Pathways

A

ADH
Catalase
CYP2E1

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15
Q

Drugs that cause hepatotoxicity

A

APAP

Troglitazone

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16
Q

Drugs that cause Cardiotoxicity

A

Doxorubicin (CHF)

Terfenadine (hERG)

17
Q

Drugs that cause Hematotoxicity

A

Dapsone
Sulfamethoxazole
Clozapine

18
Q

Drugs that cause Pulmonary Toxicity

A

Amiodarone

19
Q

Drugs that cause Neurotoxicity

A

MPPP -> MPTP -> MPP+

Sarin

20
Q

Drugs that cause Genitourinary toxicity

A

Ethylene Glycol

Diethylene Glycol

21
Q

Drugs that are pro-carcinogen by bioactivation

A

AFB
Solvent Red 1
AAF

22
Q

Toxicity Mechanisms

A 
Electrophilic Carbons
Bioactivated Electrophilic Bonds
Bioactivated Electrophilic double bonds
Allylic Carbocation
Free Radical
23
Q

Drug examples with Electrophilic Double Bonds

A

Carbamazepine
Paroxetine
Tolcapone
Diclofenac

24
Q

Drug examples with Allylic Carbocation

A

Tamoxifen

25
Q

Drug examples with free radicals

A

Isoniazid

Captopril

26
Q

Reactive oxygen species

A 
Superoxide anion
Peroxyl
Hydroxyl
Alkoxyl
Hydroperoxyl
Lipidperoxyl
27
Q

Reactive Nitrogen Species

A

Nitric Oxide

Nitrogen Dioxide

28
Q

Non-radical Species

A

Hydrogen Peroxide
Peroxynitrite
Hypochlorous Acid

29
Q

Hypersensitivity Types

A

Type 1: IgE
Type 2: IgG
Type 3: Immune Complex
Type 4: T-cell mediated

30
Q

APAP Toxicity Antidote

A

NAC (N-Acetylsysteine)

31
Q

DME Toxicity Defense Mechanisms

A

GST/EH

Oxidative Stress Defense (cat, GSH-px, SOD, GSH-R, Cyt C)

32
Q

Sarin Antidote

A

2-PAM (before aging of intermediate)

Med Chem (1 decks)

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