Final Flashcards
Where does cSCC tend to arise in dark skinned people? Is it associated with chronic inflammation, chronic wounds and scaring?
On Non Sun-exposed areas.
Yes it is associated with chronic situations
What are genetic factors for SCC
fair skin, light-colored eyes, red hair and northern european origin
Cumulative UVB sun exposure in the past ________ years of a person’s life increases the likelihood of cSCC in the presence of other risk factors.
5-10
are sites of chronic inflammation, chronic wounds, or scars are susceptible to the development of cSCC?
yes
A lesion on the vermillion border is what?
cSCC until proven otherwise!
cSCC that occurs in sun-exposed areas have what rate of metastasis
5% slow
In contrast to BCCs which only rarely metastasize (0.003%), ___ of cSCCs spread to regional lymph nodes or more distant sites (the lungs, liver, brain, skin, or bone) à a relatively poor outcome.
5-10 percent
What are the features of CSCC lesions that correlate with high risk for recurrence and regional or distant metastasis.
Depth >4mm, poorly differentiated perineural involvement intravascular invasion Located on the ear, lip, genitals or within a scar/burn/ulcer. ORAL SCC.
Larger in size, invades into the subcutaneous tissue, doesn’t arise frun sun exposure, high risk features
Although there is no uniform agreed upon screening protocol for malignant melanomas in US a what is considered the best option to identify suspicious lesions
skin survey
Individuals with atypical nevi have a ________ fold elevated risk of developing malignant melanoma.
3-20
Is there a strong association between high nevus counts and malignant melanoma. How many nevi?
Yes, more than 25
Studies demonstrate higher rates of malignant melanoma in adults with ____ or ___________ exposure to sunlight.
Extensive or
Repeated Intense
Case studies found the strongest association for malignant melanoma for _________ sun exposure and ___________ in adolescence or childhood.
Intermittent and sunburn
During what growth phase is malignant melanoma is almost always curable by surgical excision alone.
Raidal
Nodular melanomas have no identifiable ___growth phase and enter the __________ growth phase almost from their inception.
Radial
Vertical
Over 60% of superficial spreading malignant melanomas are diagnosed as thin, highly curable tumors of less than __ mm thickness.
1
Nodular malignant melanomas are the most difficult to diagnose at an early stage – at least half are greater than __ mm in thickness when diagnosed!
2
Most common type of malignant melanoma among Asians and in African-Americans is the ______Acral Lentinous Melanoma_which arise most commonly on palmar, plantar, and subungual surfaces
Acral Lentinous Melanoma
What is the single most important determinant of prognosis for a malignant melanoma?
Tumor Thickness
Stage T1: ≤1 mm malignant melanomas have a ten year survival of what?
92_ percent.
The definitive “initial” surgical treatment for primary cutaneous melanoma is a _______ down to the deep fascia.
Wide Local Incision
Because of the potential of metastasis and possible death, any biopsy that comes back positive for malignant melanoma needs to be referred for additional surgery via procedure.
look up
In the absence of physical trauma, what appears to be a subungual hematoma might be due to what type of infection.
Proteus or Pseudemonas_
When draining a subungual hematoma with any method you may have to do what?
repeat the procedure several times to provide a hole that is large enough to remain open for continued drainage.
What do you advise the patient to do if the drainage hole made in a nail for a subungual hematoma closes up and pressure and pain reoccur?
Soak it in cold water, adding peroxide to help dissolve the clot
What are the 5 etiologies of onycholysis?
- Idiopathic
- Systemic (thyrotoxicosis)
- Congenital/hereditary
- Cutaneous diseases(psoriasis, drug-induced, photo)
- Local causes (trauma, chemicals)
What are the various causes of onychogryphosis
- Acute injury
- Chronic Injury
- Infection
- Poor blood supply
- Diabetes
- Inadequate intake of nutrients
List four ways to help prevent onychogryphosis.
- Keep nails trimmed
- Avoid tight fitting footwear
- Avoid nail polish
- Avoid footwear or stockings that gather at the toes
Tinea unguium is usually caused by one dermatophyte , either T.
trichophyton mentagrophytes_____ or T _____rubrum
What are thought to be the two likely causes of ganglion cysts?
Degenerative process in the mesoblastic tissues surrounding the joint, herniation of a tendon sheath
What is the consistency of a ganglion cyst?
Smooth, rounded, multilocular
Hard/firm like a bony cartilaginous lesion fluctuant
May be cystic
What are the three typical indications for treatment of ganglia?
- Relief of soreness/pain
- Removal of unsightly mass
- Relief of the feeling of weakness