Final Flashcards
Diagnoses of Fibro-osseous lesions are determined via:
Radiographic and Clinical features
Histopathologic features are similar
Periapical Osseous Dysplasia is most commonly found where?
Anterior mandible (incisors)
Why are biopsies of Periapical Osseous and Florid Osseous Dysplasias not recommended?
Biopsy increases the risk of secondary infection due to reduced vascularity of these lesions
What is the major difference between Osseous Dysplasias and Ossifying Fibromas?
Ossifying Fibromas cause significant concentric expansion in all directions
What genetic abnormality accompanies 93% of Fibrous Dysplasia patients?
Mutation in GNAS1 gene on Chromosome 20q13.32
What is the typical radiographic appearance on Fibrous Dysplasia?
“Ground glass”
Which condition is linked to puberty?
Fibrous Dysplasia
- Does not progress beyond puberty
- 2-3% of Polyostotic form associated with McCune Albright syndrome = Precocious puberty
- Polyostotic form usually presents before age of 10
Which Fibro-Osseous lesion is associated with nerve impingement?
Fibrous Dysplasia
What diseases are differential diagnoses for Fibrous Dysplasia?
Paget’s
Periapical cemental dysplasia
Osteomyelitis
Hyperparathyroidism
Which is the only Fibro-Osseous lesion that requires treatment?
Ossifying fibroma
- Surgical enucleation
Which is the most common malignant disease?
Carcinoma (epithelial origin)
What is the most common malignancy in oral cavity?
Squamous Cell Carcinoma
Which disease causes direct bone formation vs. reactive bone formation?
Osteosarcoma
Which malignancy can often occur in patients with Fibrous dysplasia or Paget’s disease after radiation therapy?
Osteosarcoma
Which malignancy has characteristic Bence Jones proteins in the urine?
Multiple Myeloma