Final Flashcards
What is the activity of ALL beta lactams?
bactericidal, time dependent, PAE
How are ALL beta lactams metabolized and excreted?
no metabolism, renal elimination
What two adverse effects are associated with beta lactams?
type A - GI toxicity
tybe B - allergies +++, cross reactivity
What are the two aminopenicillins?
amoxicillin and ampicillin
What are the two Beta lactamase resistant penicillins? (anti staphylococcal)
methicillin, oxacillin
What are the two extended spectrum penicillins?
ticarcillin, piperacillin
What group of beta lactams has a “eagle effect”?
penicillins
What is the difference in spectrum between basic penicillins and aminopenicillins?
aminos have more aerobic gram - spectrum (both do pasteurella)
What benefits are achieved by combining penicillins and aminoglycosides?
increased penetration of aminoglycosides inside bacteria, additive or synergistic effect
What can penicillin be degraded by? (3)
GI amidases and acidity (poor oral absorption)
bacterial Beta lactamases
What two penicillins have increased oral bioavailability?
aminopenicillins and penicillin V
What two drugs can increase the half life of penicillins?
procaine and benzathine
What group of penicillins should never be used empirically?
anti-pseudomonal penicillins (extended spectrum)
What are the 3 generations of cephalexin drugs we need to know?
1st - cephalexin
2nd - cefuroxime
3rd - ceftiofur, cefovecin
What are the spectrums for each gen of cephalosporins?
1st - Gram + aerobic and anaerobic and beta lactamase +, modest gram - (but not gr - beta lactamse +)
2nd - mmore gram - (decreased gr +)
3rd - even more gram - (decreased gr +)
What cephalosporin has a very long half life for dogs and cats?
cefovecin (convenia)
What are the adverse reactions of cephalosporins?
A - GI toxicity, nephrotoxicity
B - common, cross reactivity
What group of drugs are carbapaems and monobactams?
beta lactams
What is a carbapenem drug?
imipenem
What is a monobactam drug?
aztreonam
What is the spectrum of carbapenems?
gram + and -, aerobes, anaerobes, beta lactamse +
What is the spectrum of monobactams?
most gram - (some beta lactamase +)
NOT active against gram +
What are the three peptide antibiotics?
glycopeptides - vancomycin
polymyxin B
bacitracin
What is the activity of glycopeptides?
bactericidal
both time and concentration dependent
What is the spectrum of vancomycin?
only gram + aerobes and anaerobes
What is the route of administration of vancomycin? How is it metabolized?
IV
not metabolized, renal excretion
What is the MOA of polymyxin?
disrupts cell membrane and anti-endotoxin effect
What is the activity of polymyxin B?
bactericidal, concentration dependent
What is the spectrum of polymyxin B?
only Gram - aerobes and anerobes including pseudomonas
When should systemic use of polymyxin B be indicated?
low doses for endotoxin activity
What group is Streptomycin?
aminoglycoside
What group is erythromycin?
macrolide
What group is spiramycin?
macrolide
What group is tulathromycin?
macrolide
What group is tylosin and tilmicosin?
macrolide
What group is spectinomycin?
aminoglycoside
What group is neomycin and gentamicin?
aminoglycoside
What group is amikacin?
aminoglycoside
What does the MOA of aminoglycosides depend on?
oxygen (does not do anaerobes)
What is the activity of aminoglycosides?
bactericidal (only protein synthesis that is)
concentration dependent
PAE
What is the spectrum of aminoglycosides?
gram -, only in aerobic conditions
What can aminoglycosides be synergistic with? What is the exception?
any wall or membrane disruptor but chemically incompatible with penicillins
What is the preferred admin route of aminoglycosides? What is the exception?
parenteral (exception: neomycin)
What things can inactivate aminoglycosides?
inactivated by acids (stomach, pus, drugs) divalent cations (Mg, Ca)
What is the activity of tetracyclines?
bacteriostatic, time dependent
What can inactivate tetracyclines?
di and trivalent cations - Ca, Mg, Al, Fe
How are tetracyclines metabolized? What is the exception?
no metabolism, mixed liver and renal elimination.
Doxycycline = 100% eliminated by liver
What is the activity of macrolides?
bacteriostatic, time dependent, anti inflammatory, GI prokinetic