Final Flashcards
Which of the following structures is formed by the endocardial cushions?
a. Septum primum
b. Septum intermedium
c. Interventricular septum
d. Septum secundum
e. Both A and D
b. Septum intermedium
Which of the following hormones causes regression of the paramesonephric ducts?
a. Testosterone
b. Estrogen
c. Mullerian inhibiting substance
d. Wolffian inhibiting substance
e. In both males and females, regression of the paramesonephric duct is passive and does
not require hormonal input
c. Mullerian inhibiting substance
During the second phase of hematopoiesis what is the primary location for blood cell production?
a. Liver
b. Yolk sac
c. Spleen
d. Bone marrow
e. Thymus
a. Liver
What is the primary function of the zone of polarizing activity in the developing limb?
a. Stimulating outgrowth of the limb
b. Setting up the anterior-posterior axis of the limb
c. Determining the pattern of neural ingrowth into the limb
d. Setting up the dorsal-ventral axis of the limb
e. Determining the pattern of vascular ingrowth into the limb
b. Setting up the anterior-posterior axis of the limb
Which of the following is a valid reason why the urinary system must develop prior to the genital system?
a. The degenerating metanephric tubule cells form the sex cords of the indifferent gonad
b. The epididymis forms from the mesonephric duct
c. Uterine morphology is due to the degree of fusion of the mesonephric ducts
d. The follicle cells and the seminiferous tubules form from cells of the degenerating mesonephric tubules
e. Both B and D
e. Both B and D
Organs such as the digestive tract are composed of derivatives of more than one germ layer. Which of the following statements is correct regarding the digestive system origins?
a. The endoderm gives rise to the epithelial lining
b. The mesoderm gives rise to the myenteric plexus
c. The ectoderm gives rise to the smooth muscle
d. The neural crest cells give rise to the smooth muscle
a. The endoderm gives rise to the epithelial lining
Choose the incorrect statement regarding heart development:
a. The endocardial cushions are involved in septum intermedium formation
b. The bulbus cordis becomes the right ventricle
c. The heart develops in a region of the intermediate mesoderm called the cardiac crest
d. The septum secundum forms after the formation of the septum primum
c. The heart develops in a region of the intermediate mesoderm called the cardiac crest
The metanephric blastema is induced by Wnt signaling from the:
a. Pronephric ducts
b. Ureteric bud
c. Mesonephric tubules
d. Mesonephric duct
e. Metanephros
b. Ureteric bud
Which of the following statements regarding respiratory system development is correct?
a. The respiratory system initially diverts from developing foregut via the laryngo-tracheal groove
b. Lung formation is complete before birth
c. The lung buds form from the dorsal foregut
d. The saccular stage is characterized by terminal bronchiole formation
e. All of the above statements are correct
d. The saccular stage is characterized by terminal bronchiole formation
A developing fetus will only have about 12% of the blood leaving the right ventricle entering into the pulmonary circulation from the right ventricle. Which of the following is responsible for this shunt of blood away from the lungs and where is the blood being shunted to?
a. Ductus venosus; aorta
b. Ductus arteriosus; aorta
c. Ductus venosus; inferior vena cava
d. Ductus arteriosus; inferior vena cava
e. Foramen ovale; left atrium
b. Ductus arteriosus; aorta
Upon examination of a male kitten, there is a palpable left testis within the left scrotal sac, but no palpable right testis within the right scrotal sac. There were no other abnormalities noted. Which of the following is the MOST LIKELY explanation involving the gonad of this kitten?
a. Agenesis of the right testis
b. Atresia of the right testis
c. Unilateral cryptorchidism
d. Fusion of the testes prior to descent
e. None of the above is a plausible explanation for the kitten’s abnormality
c. Unilateral cryptorchidism
With regards to digestive system development:
a. The liver and the pancreas form from the most cranial region of the hindgut
b. The stomach undergoes one 90 degree clockwise rotation followed by a 45 degree counter clockwise rotation
c. In both the simple stomach and ruminant stomach the ventral portion proliferates more rapidly
d. The urorectal septum separates the cloaca into the urogenital sinus and the rectum
e. Both B and D
d. The urorectal septum separates the cloaca into the urogenital sinus and the rectum
By which 3 properties is a stem cell defined?
a. Ability to self-renew by asymmetrical cell division, high proliferation properties and differentiation potency
b. Ability to self-renew by symmetrical cell division, high proliferation properties and differentiation potency
c. Ability to self-renew by symmetrical cell division, high proliferation properties and targeted cell death (apoptosis)
d. Ability to self-renew by asymmetrical cell division, cellular senescence and differentiation potency
a. Ability to self-renew by asymmetrical cell division, high proliferation properties and differentiation potency
Embryonic stem cells are isolated from:
a. Bone marrow
b. Fetal tissue in the first trimester
c. The inner cell mass of an embryo
d. The trophectoderm layer of a blastocyst
e. Amniotic fluid
c. The inner cell mass of an embryo
In what ways are embryonic stem cells and induced pluripotent stem cells similar?
a. They can both undergo unlimited self-renewal
b. They can both differentiate into cell types of all three germ layers
c. They both require the expression of transgenes to maintain pluripotency
d. All of the above
e. a) and b) are correct
e. a) and b) are correct
Stromal vascular fraction refers to:
a. The fraction of bone marrow aspirate containing MSCs
b. The red blood cell fraction in umbilical cord blood
c. The nucleated cell fraction of bone marrow aspirate
d. The nucleated cell fraction of adipose tissue
e. The white blood cells in umbilical cord blood
d. The nucleated cell fraction of adipose tissue
What is the embryonic origin of the biceps muscles?
a. Neural ectoderm
b. Intermediate mesoderm
c. Somatic mesoderm
d. Endoderm
e. Somite mesoderm/myotome
e. Somite mesoderm/myotome
What is the embryonic origin of the uterus?
a. Neural ectoderm
b. Intermediate mesoderm
c. Splanchnic mesoderm
d. Endoderm
e. Somite mesoderm/myotome
b. Intermediate mesoderm
What is the embryonic origin of the primary bronchus?
a. Neural ectoderm
b. Intermediate mesoderm
c. Splanchnic mesoderm
d. Endoderm
e. Somite mesoderm/myotome
d. Endoderm
What is the embryonic origin of the kidney nephron?
a. Neural ectoderm
b. Intermediate mesoderm
c. Splanchnic mesoderm
d. Endoderm
e. Somite mesoderm/myotome
b. Intermediate mesoderm
HOX genes are important for:
a. Neurogenesis
b. Myogenesis
c. Osteogenesis
d. Body patterning
e. None of the above
d. Body patterning
Which genes display “colinearity” and are involved in limb development?
a. Transforming growth factor beta superfamily genes
b. Bone morphogenic protein genes
c. Fibroblast growth factor genes
d. HOX genes
e. All of the above
d. HOX genes
The right side of the heart is a “high pressure” system during fetal life:
a. True
b. False
a. True
Aortic stenosis is often associated with hypertrophy of the right ventricle:
a. True
b. False
b. False
Blood in the umbilical vein has:
a. Low oxygen concentration
b. High oxygen concentration
b. High oxygen concentration
Endochondral ossification involves the formation of bone from mesoderm through a cartilage template.
a. True
b. False
a. True
Vertebrae are formed by:
a. Resegmentation of sclerotome derived from somites to form vertebral bodies
b. Intramembranous ossification of sclerotome mesenchyme
c. Formation of vertebral bodies at sites of Ebner’s fissures
d. All of the above
a. Resegmentation of sclerotome derived from somites to form vertebral bodies
The greater curvature of the stomach is due to:
a. The ventral portion of the dilated caudal foregut grows rapidly
b. The dorsal portion of the dilated caudal foregut grows rapidly
b. The dorsal portion of the dilated caudal foregut grows rapidly
Embryonic physiological umbilical herniation occurs to accommodate the:
a. Large liver producing blood cells
b. Large spleen producing blood cells
c. Midgut
d. All of the above
e. None of the above
c. Midgut
All lung tissues are fully formed and matured at the time of birth:
a. True
b. False
b. False
The functional kidney in the newborn and adult originates from:
a. The pronephros
b. The metanephros
c. The mesonephros
b. The metanephros
The following structures are of endoderm origin:
a. Urinary bladder and ureters
b. Ureters and urethra
c. Urinary bladder and urethra
d. All of the above
c. Urinary bladder and urethra
The uterine tubes and uterus originate from the paired:
a. Paramesonephric/Mullerian ducts
b. Mesonephric/Wolffian ducts
a. Paramesonephric/Mullerian ducts
Secreted products from Leydig and Sertoli cells are important for female phenotypic sex development:
a. True
b. False
b. False
In order to evaluate the efficacy of stem cell therapies. studies need to account for:
a. Random allocation to treatment and control groups
b. Observer bias
c. Outcome bias
d. Natural waxing and waning of disease
e. All of the above
e. All of the above
Allogenic/allogeneic cells are defined as:
a. Cells from the patient itself
b. Cells from a different species
c. Cells from a different individual of the same species
d. Cells from the same tissue
e. Cells from the same sex
c. Cells from a different individual of the same species
In Canada, there are currently no regulations on veterinarian’s use of autologous cell-based products like stromal vascular fraction or PRP.
a. True
b. False
a. True
Multipotent mesenchymal stromal cells may exert their function by:
a. Phagocytizing dead tissue in a manner similar to macrophages
b. Differentiating into the cell type of the desired mesodermal tissue
c. Centrally increasing the individual’s pain threshold
d. Altering the function of the immune system at the repair site via secreted factors
e. Mechanisms described in answer b and d
e. Mechanisms described in answer b and d
What is the embryonic origin of the cerebral cortex?
a. Neural ectoderm
b. Intermediate mesoderm
c. Splanchnic mesoderm
d. Endoderm
e. Somite mesoderm/myotome
a. Neural ectoderm
What is the embryonic origin of melanocytes?
a. Neural crest cells
b. Intermediate mesoderm
c. Splanchnic mesoderm
d. Endoderm
e. Somite mesoderm/dermatome
a. Neural crest cells
Spermatocytogenesis is the male form of gametogenesis that results in:
a. Production of spermatogonia type A by mitosis
b. Production of spermatogonia type B by meiosis
c. Formation of spermatocytes
d. Formation of spermatids
c. Formation of spermatocytes
Neurocristopathies can arise due to defects of neural crest cell migration or differentiation. Which of the following is an example of a neurocristopathy?
a. Overo lethal white syndrome
b. Hydrocephaly
c. Syndactyly
d. Cleft palate
e. Both A and D
e. Both A and D
Which of the following is a derivative of the embryonic neural tube?
a. Postganglionic autonomic neurons
b. Motor neurons
c. Ependymal cells
d. Both B and C
e. Both A and B
d. Both B and C
The large fluid-filled follicle that is preparing to ovulate is called:
a. Primary follicle
b. Secondary follicle
c. Graafian follicle
d. Primordial follicle
c. Graafian follicle
Fertilization occurs:
a. In the infundibulum region of the uterine tubes
b. In the uterus
c. In the ampullary region of the uterine tubes
d. In the cervix
c. In the ampullary region of the uterine tubes
Which part of the female reproductive tract acts as a sperm reservoir, allowing spermatozoa from the same ejaculate to reach the uterine tubes at different times?
A. Cervix
b. Uterus
c. Vagina
d. Intramural region of the uterine tubes
e. Spermatozoa from the same ejaculate reach the uterine tubes all at the same exact time
A. Cervix
What extraembryonic membrane directly interfaces with the endometrium to form the placenta?
a. Chorion
b. Allantois
c. Yolk sac
d. Amnion
e. Both A and D
a. Chorion
What kind of placenta does a pig have?
a. Diffuse, endotheliochorial
b. Diffuse, synepitheliochorial
c. Zonary, epitheliochorial
d. Cotyledonary, epitheliochorial
e. Diffuse, epitheliochorial
e. Diffuse, epitheliochorial
The horse placenta secretes a unique hormone, equine chorionic gonadotropin (eCG), to signify pregnancy. eCG production occurs in:
a. Chorionic girdle
b. Endometrial cups
c. Endometrial caruncles
d. eCG is not produced in the placenta
b. Endometrial cups
During an equine foaling it is normal to first see a “red bag” protruding from the vulva:
a. True
b. False
b. False
The diencephalon arises from the ______________ and will become the ________________ (choose the BEST answer):
a. Prosencephalon, cerebrum
b. Prosencephalon, midbrain
c. Rhombencephalon, cerebellum
d. Rhombencephalon, medulla oblongata
e. None of the above
e. None of the above
FYI… arises from the PROSENCEPHALON; will become the EPITHALAMUS/THALAMUS/HYPOTHALAMUS
Choose the most correct statement:
a. Dorsal root ganglia are made of neuronal cell bodies derived from the neural tube
b. Spinal nerves are made up of mostly afferent nerve fibres
c. Motor neurons grow out of the basal plate to meet with peripherally growing processes from the dorsal root ganglion
d. Dorsal root ganglia are made of neuronal cell bodies from cardiac neural crest
c. Motor neurons grow out of the basal plate to meet with peripherally growing processes from the dorsal root ganglion
If the somites close to a limb-forming region are removed, which of the following will be missing in the limb?
a. Nerves
b. Muscles
c. Bones
d. Phalanges
e. All of the above
b. muscles
Mammalian cleavage during early embryogenesis is characterized by all of the following EXCEPT:
a. Decrease in blastomere size following each division
b. Rapid cell cycle
c. Growth of blastomeres
d. Exponential increase in cell number
e. Production of the blastocyst
c. Growth of blastomeres
Intra-uterine Insemination (IUI) consists of:
a. Injection of a single sperm in an oocyte
b. Injection of washed sperm into the uterus with a catheter
c. In vitro fertilization of an oocyte, with fertilized embryos placed back into a recipient
d. In vitro maturation of sperm
b. Injection of washed sperm into the uterus with a catheter
Which statement is true about therapeutic cloning:
a. The making of embryonic stem cells that are used for replacing/repairing damaged tissues/organs
b. Inserting a diploid nucleus from a body cell into an egg cell whose nucleus has already been removed, producing a live offspring
c. Aims to produce a live individual identical to the one that donated the genetic material for the procedure
d. None of the above statements are true
a. The making of embryonic stem cells that are used for replacing/repairing damaged tissues/organs
Which Assisted Reproductive Technology consists of the injection of a single sperm cell directly into the cytoplasm of an egg?
a. Intra-uterine insemination (IUI)
b. Intracytoplasmic Sperm Injection (ICSI)
c. In Vitro Fertilization (IVF)
d. Reproductive Cloning (SCNT)
b. Intracytoplasmic Sperm Injection (ICSI)
The advantage of vitrification versus slow-cooling is:
a. No formation of ice crystals
b. No need for cryoprotectants
c. Lower freeze-thaw survival rate
d. There is no advantage of vitrification versus slow-cooling
a. No formation of ice crystals
There are many genes and molecules important to embryonic development. Which of the
following statements is correct regarding each molecule and its function?
a. Oct4 is important in maintaining cellular pluripotency
b. BMP acts as a neural inducer and also acts to promote cell proliferation in limb
development
c. SHH acts as a neural inducer and also acts to maintain the anterior-posterior axis in limb
development
d. Both B and C are correct
e. Both A and C are correct
e. Both A and C are correct
True or false: FGF signaling promotes cell differentiation.
a. True
b. False
b. False
Chromosomal sex is determined at the time of fertilization, but phenotypic sex is determined by:
a. WNT gene
b. SRY gene
c. Mullerian inhibiting substance
d. Wolffian inhibiting substance
e. TSPY gene
b. SRY gene
- What important process is depicted in Figure 1? (sorry, no figure)
a. Blastulation
b. Gastrulation
b. Gastrulation
In Figure 1, what structure does the letter “A” identify?
a. Permanent streak
b. Primitive streak
c. Primary streak
d. Neural tube
e. Notochord
b. Primitive streak
In Figure 1, what cells (blue) does the letter “B” identify?
a. Mesoderm cells
b. Endoderm cells
c. Hypoblast cells
d. Epiblast cells
e. Neural crest cells
d. Epiblast cells
In Figure 1, which cells (orange) does letter “C” identify?
a. Mesoderm cells
b. Endoderm cells
c. Hypoblast cells
d. Epiblast cells
e. Neural crest cells
a. Mesoderm cells
In Figure 1, which cells (yellow) does letter “D” identify?
a. Mesoderm cells
b. Endoderm cells
c. Hypoblast cells
d. Epiblast cells
e. Neural crest cells
b. Endoderm cells
In Figure 1, which cells (green) does letter “E” identify?
a. Mesoderm cells
b. Endoderm cells
c. Hypoblast cells
d. Epiblast cells
e. Neural crest cells
c. Hypoblast cells
Choose the most correct statement:
a. ESCs can be used allogenically because they are capable of modulating inflammation
b. Differentiation of pluripotent stem cells reduces their risk of tumour formation
c. The stem cell niche for HSCs is in the blood vessels
d. Cell fate is fixed
b. Differentiation of pluripotent stem cells reduces their risk of tumour formation
True or false: During development, cells usually undergo an epithelial to mesenchymal transition in order to migrate to their final locations.
a. True
b. False
a. True
The allantois contributes to:
a. Placenta development
b. Midgut development
c. Bladder development
d. All of the above are correct
e. A) and C) are correct
e. A) and C) are correct
When is the second polar body extruded during oogenesis?
a. After ovulation, before oocyte is fertilized
b. After ovulation, only if oocyte is fertilized
c. After meiosis I, during formation of secondary oocyte
d. None of the above are correct
b. After ovulation, only if oocyte is fertilized
True or false: Facial development requires the contribution of endoderm, mesoderm, ectoderm, and neural crest derivatives.
a. True
b. False
a. True
With regards to the development of the urogenital system:
a. The urinary system develops from paraxial mesoderm while the genital system arises from intermediate mesoderm
b. The primitive sex cords arise from the metanephros
c. GDNF secreted by the metanephric blastema induces outgrowth of the ureteric bud from the mesonephric duct
d. The cranial suspensory ligament becomes the gubernaculum testis
c. GDNF secreted by the metanephric blastema induces outgrowth of the ureteric bud from the mesonephric duct
Nutrigenomics is the branch of science that:
a. Examines the response of genes to food compounds
b. Examines the response of nutritional changes to metabolites
c. Examines the response nutritional constituents to changes in gene changes
d. Examines the response of genes to genetic mutations
a. Examines the response of genes to food compounds
- Tagging of a foreign gene to which of the following helps in visual confirmation of a transgene?
a. Metallothionine gene
b. 5-methylcysteine gene
c. Tetracycline Inducible gene
d. Green Fluorescent protein gene
d. Green Fluorescent protein gene
What is the difference between prognostic, diagnostic and surrogate biomarkers?
a. Analyte that signifies the presence of a endpoint (e.g., death); analyte that provides information on likely course of disease in an untreated individual or likelihood of response to a given therapy; analyte that helps achieve clinical diagnosis, respectively.
b. Analyte that helps achieve clinical diagnosis; analyte that signifies the presence of a endpoint (e.g., death); analyte that provides information on likely course of disease in an untreated individual or likelihood of response to a given therapy, respectively.
c. Analyte that provides information on likely course of disease in an untreated individual or likelihood of response to a given therapy; analyte that helps achieve clinical diagnosis; analyte that signifies the presence of an endpoint (e.g., death); respectively.
d. Analyte that helps achieve clinical diagnosis; analyte that provides information on likely course of disease in an untreated individual or likelihood of response to a given therapy; analyte that signifies the presence of a endpoint (e.g., death), respectively.
c. Analyte that provides information on likely course of disease in an untreated individual or likelihood of response to a given therapy; analyte that helps achieve clinical diagnosis; analyte that signifies the presence of an endpoint (e.g., death); respectively.