Final Flashcards
What is immunity?
The ability to ward off damage or disease.
Susceptibility
The lack of resistance to a given pathogen.
Innate immunity
-Present at birth
-Rapid response to all kinds of diseases
-Acts against all microbes the same way
-There are two lines of defense
1st line of defense
-Skin/mucous membranes
-Secreted fluids/chemicals/pH control
-Defecation/vomiting
-Lysozyme
Second line of defense
-Natural killer cells
-Phagocytes
-Inflammation
-Fever
Adaptive immunity
-Develop in response to contact with specific pathogen or antigen
-Occurs over long period of time
-Can “remember” previous contact with that specific pathogen
Lymph
-Tissue fluid formed at the post-capillary venule
-It percolates through cells taking up wastes, and is collected by the lymphatic system
Lymphatic system
Made up of lymphatic vessels which have several way stations along the way as lymph drains back to the venous system.
Lymphatic vessels/capillaries
Begin as closed-ended in tissue spaces between cells
(One way flow)
Lacteals
Specialized lymphatic vessels that exist exclusively in the digestive system in order to absorb dietary lipids.
How does lymph cycle
Lymphatic vessels flow through a local cluster of lymph nodes and then ultimately flow into one of two ducts.
Thoracic duct
-Main duct (over 75%)
-Begins as the cisterna chyli (a dilation in the abdomen)
-Collects all lymph from the abdomen and lower limbs
-Receives lymph from the left head, neck, and chest
Right lymphatic duct
-Receives lymph from right side of the head, neck and chest
Primary lymphatic organs and tissues
-Sites of stem cell division and development off immunocompetent B and T lymphocytes
Where are the primary lymphatic organs and tissues found?
Red bone marrow and thymus
Secondary lymphatic organs and tissues
-The site of most actual immune responses
-Second line of defense mechanisms of innate immunity as well as adaptive immune response
Where is the secondary lymphatic organs and tissues located?
Lymphatic follicles, lymph nodes, chief lymph node, and spleen b
Thymus
A bi-load organ with a connective tissue capsule that atrophies as we age.
T Cells
Migrate to the thymus to multiply and mature
Dendritic cells
Derived from monocytes learn from t cells and end up in the skin
Red bone marrow
Exist in flat bones and the epiphyses of long bones in adults and in nearly every bone in children
Stem cells within the marrow
Produces both B and T lympocytes
Where do T cells mature
T cells migrate to the thymus to mature
Where does B cells mature
B cells stay in the bone to mature
B
Bone marrow