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IMMUNO > FINAL > Flashcards

FINAL Flashcards

1
Q

Signal 3 cytokines

A

IL12, IL4, IL6, TGF-B

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2
Q

TH1 differentation is stimulated by what

A

IL12

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3
Q

What cytokines does TH1 produce

A

IL2, IFN-gamma, TNF-alpha

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4
Q

Functions of TH1

A

activate macrophages –> enhanced phagocytosis–granuloma formation
activate cytotoxic lymphocytes
help b cells produce ab
inhibit TH2

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5
Q

TH2 differentation is stimulated by

A

IL-4

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6
Q

What cytokines does TH2 produce

A

IL-4, IL-5, IL-13

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7
Q

Functions of TH2

A

produce eosinophils and mast cells
inhibit TH1

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8
Q

TH17 differenation is stimulated by

A

IL6 and TGF-Beta

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9
Q

What cytokines does TH17 produce

A

IL-17, IL-22

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10
Q

functions of TH17

A

neutrophilic response
barrier tissue defense

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11
Q

Effector function of IL-2

A

Proliferation of T cell –> Activation of NK cells

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12
Q

effector function of IFN-gamma

A

polarization of macrophages (M1) –> activated CD8+ T cell

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13
Q

How do TH1 cells activate macrophages

A

Via IFN-gamma and CD40 ligand signaling

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14
Q

Effector function of TNF-alpha

A

Activation of endothelia –> Apoptosis of infected cell

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15
Q

Effector Function of IL4

A

B Cells (IgE and IgG4production)

from TH2 cell

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16
Q

Effector function of IL5

A

eosinophils – degranulation – parasitic destruction

17
Q

Effector function of IL13

A

synergizes with IL4 – polarization of M2 – promote wound healing

18
Q

Effector Function of IL17

A

IL6, IL8 – inflammation
G-CSF – neutrophil numbers

19
Q

Effector functions of IL22

A

antimicrobial peptides (Beta defensins)
Proliferation and ECM production

20
Q

CTL release what cytotoxins to induce apoptosis

A

perforin and granzyme

21
Q

CTL ligation of death receptors

A

Fas ligand binds Fas (receptor)

22
Q

What could outcompete Caspase-8 binding to FADD and block apoptosis

A

c-FLIP which can also block TNF-alpha mediated apoptosis

23
Q

What cytokine can drive expression of Fas and FasL expression on activated T cells

A

IL2

24
Q

O Malt vs D Malt

A

O = inductive – where immune response is induced
D = effector site – ab are secreted

25
Q

INNATE IMMUNITY

membrane bound mucin molecules combined with glycolipids = thick layer which provides physical barrier that prevents microbes from contact with epithelial layer

A

Glycocalyx

26
Q

what are the main antimicrobial peptides in the small intestine called

A

a-defensins produced by Paneth cells

large intestine = B-defensins

27
Q

these proteins block bacterial colonization of the mucosal epithelial surgace
have bactericidal effects against G+ bacteria

A

REG III lectin proteins
regenerating islet derived proteins

released via paneth cells

28
Q

peyers patch lies beneath

A

Follicle associated epithelium

29
Q

what cells allow antigens to enter the peyers patch via transcytosis

A

M CELLS = part of FAE

IMMUNO (2 decks)

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