Final Flashcards
Macronutrients
Carbohydrates, lipids, proteins
Micronutrients
vitamins, minerals
carbohydrate
4 kcal/g; provide energy #1
lipid
9 kcal/g; growth & development, regulation, energy #2; triglycerides (saturated vs. unsaturated), phospholipids, sterols
protein
4 kcal/g; structure, g & d, regulation, energy #3; contains nitrogen
Cohort study
study of population free of a disease over many years and observe whether those with or without a factor present develop the disease or not
case-control
compare those with a condition to those without
double-blind
research and participants do not know whether they received treatment or placebo
estimated average requirements (EAR)
nutrient intake amounts estimated to meet the need of 50% of the population
recommended dietary allowances (RDA)
nutrient intake amount to meet needs of 97-98% of population at a specific life stage; =1.2(EAR)
adequate intakes (AI)
RDA for nutrients with insufficient research; still covers 97-98% of population
tolerable upper intake levels (UL)
maximum tolerable chronic daily intake of a nutrient (does not cause adverse effects)
estimated energy requirements (EER)
kcal intake needed to match energy use
acceptable macronutrient distribution ranges (AMDR)
not DRI; macronutrient intake (% energy) associated with reduced risk of disease
5 DRIs
EAR, RDA, AI, UL, EER
AMDR for carbohydrates
40-60%
AMDR for lipids
15-25%
AMDR for proteins
25-35%
MyPlate recommendations
balance calories, increase vegetables, fruits, whole grains, low-fat or fat-free dairy, decrease sodium and sugary drinks
Dietary Guidelines for Americans (DGAs)
gov’t guidelines put in by the USDA and DHHS released every 5 years; goal is to meet nutrient needs and reduce risk of chronic disease; reflect scientific expert consensus; policy, education and programs
Energy density
kcal > grams
nutrient density
nutrient value (= amount in serving / DRI value) > kcal; assesses nutrient quality
FDA
regulate the marketplace specifically the products
FTC
regulates the marketplace specifically advertising
Goal of digestion
breaking down large compound in food into smaller molecules to be absorbed and used by the body
Mouth (1)
mechanical (chewing, moisten) and chemical (amylase, lipase, lysozyme); saliva (taste)
Esophagus (2)
food (now a bolus) to stomach through lower esophageal sphincter via peristalsis
Stomach (3)
minimal nutrient absorption -> water, alcohol; mechanical (mixing and churning) into chyme; protein breakdown, some fats, vitamin B-12 absorption, no carbs; major hormone = gastrin
Small intestine (4)
chyme thru pyloric sphincter; major site of digestion: water, glucose, amino acids, fats, vitamins, minerals; major hormones: cholecystokinin (CCK) and secretin
Large Intestine (5)
absorb water and electrolytes, form and remove feces, house microbiota; water, some fatty acids, vitamin K and biotin
secretions of the stomach
mucus, gastric lipase/pepsinogen [chief cells], intrinsic factor, HCl (denatures proteins) [parietal cells]
accessory organs
liver, gallbladder, and pancreas; produce emulsifiers, hormones, and enzymes; all emptied and mixed in small intestine*
bile
emulsifier, made by liver, stored in GB, fat digestion
pancreas secretions
bicarbonate (neutralize acidic chyme), pancreatic amylase, lipase, and proteases
intestinal enzymes
peptidases, disaccharidases, lipases
purpose of villi and microvilli
increase surface area of small intestine for more absorption
carbohydrate “purpose”
digestable (starch, sugar) - energy!
indigestible (fiber) - bowel health
recommendations for peps with lactose intolerance
<12g lactose at a time (1 cup of milk), drink small amounts of milk, consume dairy with meals, yogurt and hard cheese»_space;>, use lactase products
Digestion & Absorption of carbohydrates
- Mouth - salivary amylase (enzyme) - PS into smaller PS and DS
- Stomach - nothing bc of HCl
- Small Intestine - MAIN SPOT - pancreatic amylase
a. absorptive cells of SI - DS and MS - active transport and facilitated diffusion - Large intestine (indigestible carbs) - bacterial enzymes or excreted
- transported thru bloodstream to energy cells or for storage (glycogen in liver and muscles or fat)
type 1 diabetes
immune-mediated destruction of insulin-producing beta-cells; 5% of cases; reduced or no insulin; no real cause tbh
type 2 diabetes
insulin resistance or loss of cell responsiveness; 90% of cases; associated with inactivity and obesity
Diabetes prevention program
goal: lose 7% of body weight and maintain this weight loss thru eating less fat and calories, exercising, meetings/phone calls
outcome: lower change of Type 2 in treatment group, this chance decreases as time went on
insulin
released by beta cells when BG is elevated; glucose is transported to body cells and glucose is converted to glycogen
glucagon
released by alpha cells when BG is low; glycogen is broken down into glucose, increase gluconeogenesis
triglyceride
3 fatty acids + glycerol backbone
essential fatty acids
omega-3 and omega-6
sources of essential fatty acids
omega-3 - alpha-linolenic acid (walnuts, seeds, oil) - DHA (fish)
omega-6 - arachidonic acid (meat, oils)
DHA and EPA function
improves cognition, behavior, and mood; reduces risk of macular degeneration; normalizes blood lipids
arachidonic acid function
regulates BP; increases blood clotting
function of phospholipids
cell membrane component, emulsifier
function of cholesterol
makes sex hormones, active form of vitamin d, cell membrane, cortisone, bile, chylomicron
digestion of lipids
- mouth - lingual lipase
- stomach - gastric lipase
- intestine** - cholesterol esterase, phospholipase, CCK, bile, pancreatic lipase
- micelle enters absorptive cells
absorption of lipids
- remove fatty acids and monoglyceride from micelle
- make a new triglyceride
- packaged with cholesterol and coats with protein and phospholipid –> chylomicron
- chylomicron enters lacteal (lymphatic system) and bloodstream (near heart)
transportation of lipids
- chylomicron travels, LPL breaks down fat, chylomicron remnant back to liver
- fat leaves liver in VLDL, transported to cells via LPL, forms LDL
- LDL taken up by receptor pathways (body cells) and by scavenger pathways (blood vessels)
- HDL arises from liver, transfers cholesterol from body cells to other LPL
lipoprotein lipase (LPL)
hydrolyzes circulating TG from chylomicrons and VLDL to free FA and glycerol, FA to cells for energy, glycerol to liver; we don’t eat these
chylomicron
triglycerides
very low density lipoprotein (VLDL)
triglycerides mainly
low density lipoprotein (LDL)
cholesterol mainly
high density lipoprotein (HDL)
protein mainly
atherosclerosis, heart disease, and lipids
excess LDL in blood –> macrophages are killed by cholesterol build up which forms plague and thus atherosclerosis
9 essential amino acids
phenylalanine, valine, tryptophan, threonine, methionine, histidine, isoleucine, leucine, lysine; obtained by diet, body does not make
how body back proteins
DNA (genes) > mRNA > amino acids > peptide bond > protein
protein function
make body structures, maintain fluid and pH balance, form enzymes, hormones, and neurotransmitters, transport proteins, source of energy (gluconeogenesis)
protein digestion and absorption
- stomach - HCl denatures (no shape = no function), pepsin breaks chains
- small intestine - CCK and secretin, protease
- amino acids activity absorbed
- liver
amino acid use in the body
body proteins, supplied by diet and recycling, making new compounds (no storage), transamination, deamination
transamination
transferring of an amino group from 1 amino acids to the carbon of a new amino acid (new NEAA)
deamination
amino group > ammonia > urea
carbon skeleton > glucose, energy, fat
kidneys: urea + ammonia + creatinine
urination
nitrogen balance
determines protein needs
equilibrium = protein intake = protein losses
protein sources
70% meat, poultry, fish, milk, cheese, legumes, nuts
30% other
high quality (complex) proteins
contain all 9 EAA, support body growth and maintenance, animal protein
lower-quality (incomplete) protein
are low in or lack one or more EAA, can’t support body growth and maintenance, plant protein (except: quinoa, soy)
limiting amino acid
the EAA found in the lowest concentration in a protein source; reduces protein’s ability; often lysine, methionine, threonine, tryptophan, isoleucine
risk of high protein intake
dehydration, continued decline in kidney function, increase urinary calcium losses
metabolism
the sum of all chemical reactions in the body; convert food into energy
anabolic pathway
small compounds to large compounds; requires energy; glucose, fatty acids, cholesterol, and amino acids are building blocks
catabolic pathways
break down compounds; results in release of CO2, H2O, and ATP
glycolysis
glucose (6-C) oxidized to form 2 molecules of pyruvate (3-C) + NADH + H+ + 2ATP; occurs in cytoplasm; anaerobic; reversible
Citric acid cycle (TCA) / Krebs cycle
Acetyl-CoA (from pyruvate) eventually leads to guanosine triphosphate (GTP) which can be converted into 2 ATPs; oxaloacetate is then regenerated; FADH2 formed as well as NADH and H+
electron transport chain (ETC)
primary site of ATP production; oxygen is the final acceptor of electrons during aerobic respiration; about 32 ATP and H2O produced