Final Flashcards

1
Q

UTI - Risk Factors

A

Age

Immobility

Instrumentation and urinary catheterization

Atonic bladder (spinal cord)

Increased sexual activity

Spermicide associated in use with diaphragm

Uncircumcised penis

Obstruction (Renal calculi, Prostatic Hyperplasia, Malformations or urinary tract abnormalities)

Constipation

Women is greater than men (Anatomic variations, Surgical or natural menopause without hormone replacement therapy, Pregnancy)

Kidney transplantation

Diabetes Mellitus

Partners of Viagra

STDs

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2
Q

UTI - Pathogenesis

A

Most common route: Urethra -> Bladder

Upper or Lower Urinary Tract Infection

Blood borne

Fecal associated gram negative (E. coli – 80%, Staphylococcus – 5-15%)

Acquired via lymphatic system

Prevention: Intermittent/condom catheter

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3
Q

Urinary Incontinence - Definition

A

loss of bladder control or being unable to control urination

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4
Q

Stress Incontinence

A

Physical exertion-bending, sneezing, coughing ->

Increase intrabdominal pressure ->

Weakness of PFM (external urethral sphincter) and failure of internal urethral sphincter (IUS)

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5
Q

Urge Incontinence (Overactive incontinence)

A

Sudden desire

Detrusor instability – not fully understood

Triggers: Running water, anxiety, arrival at home

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6
Q

At what age does incontinence typically occur?

A

> 60 years

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7
Q

Normal characteristics of urine

A

Color: Yellow-Amber

Urochome – waste product during protein metabolism

Voiding: 3-5 hours and in elderly 2 hours

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8
Q

Abnormal characteristics of urine

A

Negative: Glucose, Ketones, Blood, Protein, Bilirubin, RBC, WBC

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9
Q

Pyelonephritis

A

Bacteria ascending from bladder to kidney

Cause: Vesicoureteral reflux (Backflow of urine into the kidneys)

Clinical Manifestations: Abrupt, Murphy’s Sign (punch costal-vertebral angle)

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10
Q

Renal Cell Carinoma

A

Tumor in kidneys

Palpable abdominal mass

Hematuria – 50%

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11
Q

Wilms Tumor (nephroblastoma)

A

Most common in children

Malignant

Clinical manifestations: abdominal mass

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12
Q

Renal Calculi - Nephrolithiasis

A

Acute “Colicky” pain – flank pain radiates to groin or perineal area (scrotum in males and labia in female) with hematuria

Severe pain – no comfortable position

(stones)

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13
Q

Renal Cystic Diseases

A

Cyst with fluid or tubular elements (semi solid) ->

Degeneration of renal tissue ->

Obstruction of urine flow

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14
Q

Polycystic Kidney Disease (PKD)

A

Significantly enlarged kidneys (palpable abdominal mass)

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15
Q

What is Chronic Kidney Disease?

A

Progressive loss -> End Stage Renal Disease (ESRD) -> Require dialysis or transplant

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16
Q

CKD - Pathogenesis

A

Release of angiotensin leads to VC

Reduce surface area for filtration -> Reduced Glomerular Filtration Rate (GFR)

Afferent, filtration system , bowman space, proximal tubule, into distal convulant tubule leads to excretion.

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17
Q

CKD - Stages w/values

A

G1: Normal GFR** (> or = 90mL/min) but other signs and symptoms indicating kidney disease **

G2: Kidney damage with midly decreased GFR (60-89 mL/min)

G3a: Mildly to Moderately decreased GFR (45-59 mL.min)

G3b: Moderately to Severely decreased GFR (30-44 mL/min)

G4: Severely decreased (15-29 mL/min) **Systemic damage **

G5: Kidney failure (ESRD, GFR ,15 mL/min) Systemic damage

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18
Q

Stage G1

A

Blood Urea Nitrogen (BUN) and Creatinine – typically normal

Stage 1 – reversible (DM), remain indefinitely, some progress

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19
Q

BUN and Creatinine

A

If kidney is damaged -> Urea retention is high in blood (BUN)

Creatine provides energy to muscles and forms Creatinine (byproduct)

Creatinine travels in blood and excreted in urine

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20
Q

Stage G2

A

Damage capillaries – leak albumin in urine

Can remain here if proper control of HTN and blood glucose

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21
Q

Stage G3a-b:

A

More noticeable albumin in urine than blood -> Azotemia

Azotemia: increased BUN and Creatinine (Fever, nausea, etc.)

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22
Q

Stage G4

A

Kidney not able to function

Proteinuria (albuminuria): Excess amounts of urine

Increased BUN and Creatinine

Increased renin -> hypertensive -> progress to stage 5
(Renin being made causes VC leads to HTN)

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23
Q

Stage G5

A

Failed kidney often needs multiple dialysis and transplant

Uremia – nausea, vomiting, anorexia, lethargy, pruritis (itching), sensory/motor neuropathy, pericarditis, impaired heart function, asterixis, seizures

Kidney cannot excrete toxins

Not able to maintain pH, fluid, electrolyte

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24
Q

Implications of PT - Kidney Disease

A

Aware of early signs and symptoms

Always ask: Hematuria, unexplained weight loss

Constitutional Symptoms (aka red flags)

Unexplained or insidious onset of back pain, flank or shoulder pain

New onset of mental state changes or increased confusion – delirum or confusion

Appropriate catheter care – obubstructed flow
(Do not hang the urine collection bag above the level of the bladder, never allow kinking, do not rest it on the floor)

Sternal pain or mass – most common due to metastasis to sternum

HTN – due to obstruction (VC increased leads to this)

Risk for UTI

Increased risk for cerebral and aortic aneurysm (weakening of blood vessels)

Risk for mitral valve problems (more fluid in blood leads to more strain)

Intermittent and sometimes not severe colicky pain

Unilateral back pain – thoracolumbar junction to illiac crest

Murphy’s sign (palpation)
- Treat or refer?
–Refer but screen for more information

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25
Implications of PT - Chronic Kidney Disease
Analgesic Nephropathy (toxicity due to chronic NSAIDs) HTN Meds (Angioedema is swelling of face, mouth, or throat; educate your patients to slowly rise, dangling feet and legs before standing, educate to report unusual swelling) Short Term Memory Deficits Osteoporosis Education (Avoid bending and twisting)
26
Implications of PT - Dialysis
Do not measure BP on the access site Watch for HTN and Depression Hand hygiene is most important – contact transmission (WBCs are being urinated our due to condition so infection risk is high) Loss of lean body mass masked by fluid retention and weight gain (lose all protein in muscles) Dialysis hypotension is common – drop in SBP >20 mm Hg or a decrease in Mean Arterial Pressure by 10 mm Hg Ischemia of the limb: due to Thrombus formation in the access site Itching and HS reactions
27
Exercise Considerations - CKD
Mild to moderate strength and mobility training – longer duration needed (slowly increase intensity) 3x/week at 40-70% of target HR Before, during, after dialysis exercise is fine (watch for signs and symptoms) Dialysis and non-dialysis days are fine
28
Exercise Considerations - ESRD (End Stage Renal Disease)
Use RPE to monitor Exercise Exercise 4-6x/week, interval training **No exercise if K (potassium) is >5 mEq/L** BP >200/100 mm Hg – No exercise
29
Implications of PT - Urinary Incontinence
Bladder Training – Diary and Voiding Schedule Hypotension precautions – slow rise from the bed Pelvic Floor Muscle Exercises and Electrical Stimulation -10 reps, 3-5x a day -Vaginal Cone -Biofeedback for relaxation
30
GI Disorders - Signs & Symptoms
* Nausea and Vomiting * Diarrhea * Anorexia * Constipation * Dysphagia * Achalasia (difficulty passing food) * Heartburn * Abdominal pain * GI bleeding (Hematemesis, Melena, Hematochezia) * Fecal (Incontinence) Allways look for Constitutional Symptoms (Red Flags)
31
Causes of intrabdominal pressure
Lifting Straining Bending over Prolonged sitting or standing Chronic or forceful cough Pregnancy Ascites Obesity Congestive Heart Failure Low-Fiber Diet Constipation Delayed bowel movement Vigorous exercise
32
Hernia - Pathogenesis
Increased abdominal pressure + enlarged cardiac sphincter, pushes stomach through diaphram
33
Hernia - Clinical Manifestations
Inguinal Hernia - Intraabdominal pressure can lead to this Sliding Hernia - Heartburn in 30-60 minutes after meal Large Sliding hernia - Substernal pain
34
Hernia - PT Implications
Avoid flat supine position and exercise that requires valsalva maneuver Educate about intraabdominal pressure (Flex: Breath in; Extend: Breath out
35
GERD (Gastroesophageal Reflux Disease) - Pathogenesis
Reflux (backward flow) of gastric contents into the esophagus due to relaxation of lower esophageal sphincter or alteration in esophageal acid clearance
36
GERD - Complications
Esophagitis -> Erosions and Ulcer -> Scarring -> Narrowing of esophagus (difficulty swallowing)
37
GERD - Signs & Symptoms
Heartburn – burning sensation from stomach and rising to chest 30 to 60 minutes after large meal or spice foods, meal with alcohol Radiate to throat, back and chest Nighttime is common – lying down
38
GERD - PT Implications
Promote -Weight loss (overweight -> excess abdominal fat -> pressure on stomach) -Swimming and biking than agitative activities (running and aerobics) Avoid -Strenuous exercise – inhibits gastric and small intestinal emptying -High calorie and fatty food immediately before exercise Positioning -More upright position -Esophageal sphincter strengthening -Left side lying (prevent regurgitation, aspiration, and promote oropharyngeal accumulations)
39
Gastritis
Disorder to the mucosa (not muscularis mucosa) Acute: Hemorrhagic or erosive (NSAIDS and Asprin)
40
Gastritis - Signs & Symptoms
Epigastric pain with abdominal distension, heartburn, Occult GI bleeding
41
Peptic Ulcer - Patho
Erosion or ulcer of stomach or duodenum due to mucosal insult
42
Peptic Ulcer - Signs & Symptoms
-Epigastric pain – burning, cramping, aching near xiphoid -Radiates to back, midthoracic back, upper quadrant, right shoulder -Perforation of stomach or duodenum - Coffee-ground emesis (vomiting blood), melena (dark, tarry stools) - Back pain relieved by antacids –GI and refer
43
Celiac Disease (Dermatitis) - Patho
Exposure to gluten -> T-cells on intestine (hypersensitive) -> Inflammation and destruction of intestinal cells -> Complications – Cancer, osteoporosis, etc.
44
Dermatitis - Clinical Manifestations
No symptoms to life threatening (late diagnosis) GI symptoms Nutritional deficits – folate, iron, Vit B12, fat-soluble vitamins Skin: Dermatitis Herpetiformis – rash with intense itch
45
What is this?
Dermatitis Herpetiformis
46
Inflammatory Bowel Disease (IBD) - Two types:
- Crohn's Disease - Ulcerative Colitis
47
Crohn's Disease
Chronic, lifelong, **inflammatory diorder- any segment of the intestine can affect all layers of intestines.** **Skip lesions – diseased areas of intestine with normal intestines between**
48
Ulcerative Colitis
Chronic inflammatory disorder of the mucosa of the **colon** – typically rectum -> proximal involvement to entire colon
49
IBD - Clincial Manifestations
Joint problems – Sacroilitis, monoarthritic, polyarthritic. Migratoey arthralgia (first manifests (sometimes before bowel symptoms) Ileum – periumbilical pain, lower right quadrant, can refer low back Psoas abscess – due to extension of intraabdominal infections - Flexion deformity with pain in extension, fever, lower abdominal pain buttock, hip, thigh, knee; antalgic gait. - Muscle Tests (Obturator and Iliopsoas (can also do palpation))
50
Dehydration - Symptoms
Dry lips, hands Headache Brittle hair Incoordination Disorientation
51
Irritable Bowel Syndrome
Chronically recurring abdominal pain or discomfort associated with altered bowel habits – no structural, inflammatory, or biochemical abnormalities **Unknown cause **
52
IBS - Clincial Manifestations
Pain – steady or intermittent, morning or after eating **Typical: lower left quadrant pain and constipation and/or diarrhea** **Often: Relief with evacuation** Tend to disappear during sleep – Nocturnal GI symptoms suggests other GI disorder
53
Diverticulitis
Fecal matter goes inside and causes inflammation in intestines
54
Diverticulitis - Clinical Manifestations
Diverticulosis: Asymptomatic: mild, nonspecific, episodic pain Diverticulitis: 75% uncomplicated. Left quadrant episodic or constant abdominal pain (often left side – sigmoid) 10-15% - urinary symptoms (bladder) **Eating and increased abdominal pressure can increase pain. Bowel movement or passage of flatus – temporary or complete relief.**
55
Diverticulitis - When to refer?
Back pain of non- traumatic or unknown origin – referral if needed
56
Colorectal Cancer - Signs and Symptoms
Cardinal Sign: Bright Red Stool (rectum) Diverticulosis, anal fissures, and hemorrhoids
57
Appendicitis - Clincial Manifestations
Acute appendicitis: **Sequential abdominal pain** (epigastric, periumbilical or right lowe quadrant) **Constant Right lower quadrant pain/tenderness** **Older adults – slight increase in temperature, vague and mild pain, confusion** **Women – Acute pelvic pain**
58
Appendicitis - PT Implications
Early recongition is critical Typical presentation: right thigh pain, groin (testicular), pelvic pain, referred to hip Pinch an inch test -> Positive if it reproduces right lower quadrant pain
59
Peritonitis - PT Considerations
Mostly hospitilized Monitor vitals Semi-Fowler position (head an torso raised between 15-45 degrees Raise the side rails Extreme caution during positional changes – severe pain – report to team
60
Hepatitis
Inflammation of the liver
61
Hepatitis A
Virus (acute infectious condition) Infection route: Fecal-oral, contaminated food or water, person-person contact
62
Hepatitis B
- Serum Hepatitis - **Blood, body fluids/tissues, oral or sexual contact** - Can lead to cancer - Second major cause of cirrhosis
63
Hepatitis C
Same as Hep B Virus! Blood, body fluids/tissues, oral or sexual contact
64
Liver Disease - Signs and Symptoms
- Jaundice - Asterixis - **Dark Urine** - **Spider angiomas (branched dialations of supericial capillaries)** - **Pain: Right shoulder pain** - **Right Upper Quadrant Pain** - GI symptoms
65
Jaundice
Aka Icterus Overproduction of bilirubin
66
Asterixis
Flapping tremor or liver flap and numbness (misinterpreted for carpal tunnel syndrome) **Inability to maintain wrist extension with forward extension of the upper extremity – quick, irregular flexion and extension of the wrist**
67
Cirrhosis - S & S
Ascites Bleeding gums Frequent and heavy nose bleeds Hematemesis Light stools (almost white) and **Tarry stools** Change in dress – shoes unlaced or wear slippers? - **Edema – bilateral feet and ankles**
68
Gall bladder - Clinical Manifestations
**RUQ pain with radiation to right scapula (below or between scapula)** **Worsen with fatty meal** **Murphy’s sign: Pain – subcostal margin palpation as patient inhales**
69
Acute Pancreatitis - Signs & Symptoms
Mild to profound pain with systemic effects **Abdominal pain – RUQ (dull to maximum intensity within 10-20 minutes)** **Back pain** **Pain after meal**. No comfort with positional change Trigger: High fat meals Severe: Tachycardia, Tacypnea, hypoxia, pancreatic fluid filled collection
70
Pancreatitis - Patho
Chronic Pancreatitis Chronic inflammation -> irreversible changes **Cause: Alcohol (>50% of cases) metabolite acts as a toxin**
71
Pacreatitis - Clinical Manifestations
**Epigastric pain – radiates to back** **Pain worsens with meal but relieved knee to chest or forward bending**
72
Pancreatitis - PT Implications
**Preferred position for both acute and chronit pancreatitis** - leaning forward, sitting up, knee to chest position in side lying Even small ice chips can increase pain - Do not give any food unless nurse/physician allows. **Document**
73
Thrombogenesis
Formaiton of blood clots
74
Types of thrombus
Arterial – Platelet rich (MI, CVA, PAD) -> amputation -> death Venous – RBCs and Fibrin (Ex: SVT, DVT
75
Embolus
A solid mass, gas, liquid, fat moves within blood vessel and lodges at a distant site
76
Prothrombin Time (PT)
Measures how fast blood can clot Normal: Range 11 to 13.5 seconds
77
Partial Thromboplastin (PTT)
Monitor patient response to anticoagulants
78
D-dimer
Dissolution of Clot -> Fibrin threads (D-dimer) (>500 ng/mL) -> moderate to high risk (DVT)
79
Wells Clincial Prediction Rule
-2 to 0: Low probability 1-2: Moderate > or = 3: High
80
Hemorrhage - Def
Blood escaping from a ruptured blood vessel
81
What is this?
subdural hematoma
82
What is this?
Ecchymosis
83
What are these two called?
Purpura (Right) and Petechiae (Left – small)
84
Edema - Def
Accumulation of fluid within interstitial tissues or within body cavities
85
What is this called?
Anasarca
86
Anasarca - Def
Generalized Swelling
87
Common causes - Anasarca
Liver failure Kidney failure Right sided heart failure
88
Anasarca - mechanism
- Hydrostatic force – water pushes it out - oncotic – protein, increases pressure - No protein, no oncosing pressure to push stuff back - Ex: Liver - Produces no protein -> We have water outside, no proteins -> Pitting
89
Pitting
Often associated with non-lymphatic obstruction Low protein, high water. Easier to treat.
90
Non-Pitting
Often with chronic lymphatic obstruction Harder to treat. High protein.
91
Types of shock
Hypovolemic: loss of more than a fifth of blood plasma leading to reduced tissue perforation. Insufficient amount of blood for the heart to pump leads to organ failure. Cardiogenic: Unable to properly pump oxygen rich blood around Reduced system vascular resistance
92
Shock - Signs & Symptoms
Tachycardia Tachypnea (shallow/narrow breaths) Cool extremities Decreased pulses Decreased urine output Altered mental status
93
Atherosclerosis
Plaque (a fatty mass protruded in the blood vessel lumen) Beginning: simple and reversible (Exercise and diet) Later: Endothelial cells swollen with accumulation of lipids and develop gaps between endothelial cells
94
Atherosclerosis - Modifiable RF
**Shown to reduce: Smoking – Nicotine (increases fibrinogen and produces some chemicals that directly affect BV) Elevated LDL/Total Serum Cholesterol HTN Likely reduce Obesity Physical Activity is equal to high cholesterol, smoking and high BP Diabetes (Target A1C <6.5% Low HDL 60% of adults in the US lead a sedentary life compared to HTN (10%), hypercholesterolemia (10%), smoke one or more packs a day (18%)**
95
Atherosclerosis - Non-modifiable RF
Age (Women >55; Men >45), Gender (male), Genetics, Ethnicity, Infection (viral, bacterial)
96
ABI - Normal/Abnormal
Normal: 1.0-1.4 Abnormal: Less than or equal to 0.8. No support stocking! Artery is constricted already, do not want to cause more vasoconstriction.
97
BP Guidelines
98
Orthostatic Hypotension - Patho
Autonomic nervous dysfunction (Smooth Muscle – heart and BV – heart-beat, widening BV) Can cause hypotension: L-dopa, Nitrates, Calcium channel blockers
99
Hypotension - Signs & Symptoms
Dizziness Blurring or loss of vision Syncope or fainting In older adults: Unexplained or unexpected falls, acute or chronic mental confusion, cardiac symptoms Lethargy, weakness
100
HTN - Signs & Symptoms
Asymptomatic: Elevated BP is only sign in early stages Headache (worse in morning – cortisol, worse on walking) Vertigo Flushed face Spontaneous epistaxis (nosebleed) Blurred Vision Nocturnal urinary frequency Progressive HTN - CV Symptoms: Dyspnea, orthopnea, chest pain, leg edema - Cerebral symptoms - confusion
101
Aneurysm - Patho
1. Loss of smooth muscle cells 2. Increased matrix metalloproteinase – degradation of elastin Plague -> Erode -> Stretching of inner/outer layer -> Sac formation
102
Aneurysm - Def
Abnormal stretching (dilation) of blood vessels (typically > or = 50% of the diameter) - arteries and veins
103
Abdominal aneurysm
4x more common Mostly asymptomatic Intermittent or constant pain **Mild to severe mid-abdominal Groin, genitalia, buttock, legs or flank pain Abdominal heartbeat or dull ache – supine Back pain may be the only symptom before rupture > or = 5 cm -> rupture**
104
Abdominal aneurysm - S & S
Sudden Severe Headache Nausea and vomiting Pain above and behind one eye Sensitivity to light Drooping eye lid
105
abdominal Aneurysm - PT Implications
Single or bilateral SLR (single leg raise) - manual muscle testing precautions Only one leg at a time! Always palpation for mass before any abdominal procedures – manual therapy or soft tissue/scar mobilization
106
DVT - RF
Hospitalization/Immobilization Cardiac Failure Surgery Fracture or dislocation Local trauma Smoking Genetics Neoplasm Diabetes Mellitus Obesity Previous DVT >60 years old
107
DVT - S & S
Dull ache or tight feeling in legs Pain or tenderness in calf Leg or calf swelling - Pitting edema Warmer skin Dilation of superficial veins Cyanotic – severe obstruction
108
DVT - Precautions
Compression and anticoagulation are standard Anticoagulant therapy - Monitor for blood in urine, stool, teeth, or any bleeding
109
DVT - Ambulation
Warfain (Brand name: Coumadin) - Monitored by PT reported as INR Do not ambulate until you receive results Un-fractioned Heparin – monitored by PTT Ambulate if normal Low molecular weight heparin (LMWH) - almost immediately
110
What is this?
Varicose Veins
111
Varicose Veins - S & S
Dialted, tortuous, elongated veins beneath skin upon standing
112
Varicose Veins - PT Implications
Education - Avoid – prolonged standing, sitting, corssing legs, sitting too high or deep, constrictive clothing Compression – Gold standard Do ABI before compression - Want to make sure it is venous NOT arterial. We don’t want to compress BVs if it is arterials because we don’t want vasoconstriction.
113
Chronic Venous Insufficency - S & S
Hemosiderin – stores iron in tissues Venous stasis ulcer (80% of ulcers) Can be very painful
114
Pulmonary Embolism - Clincial Manifestations
**Can lead to silent death Depends on size and location: Pleuritic chest pain – inhalation and exhalation Hemoptysis (cough up blood)**
115
Angina - Pathogenesis
Myocardial oxygen supply **DOES NOT** meet an increase in Myocardial Oxygen Demand. Heart is supplied with blood from the coronary arteries. Without oxygen leads to chest pain. Causes: Artherosclerosis, Aneurysm, Cocaine use (Sympathomimetic effect, increases HR and contractility), **>90% cases caused by Coronary artery occlusion (one or more coronary artery)** - Metabolites in the ischemic cell or stretching of myocardium -> irritates myocardial fibers -> myocardial pain
116
Angina - Types
* Stable Angina * Unstable Angina
117
Stable Angina
**Classic Exertional Angina** **Symptoms relieved with rest or with Nitroglycerin (<15 minutes)** Predictable using **Rate Pressure Product** **(RPP = HR x SBP)** Measures stress on cardiac muscle
118
Unstable Angina
**Unpredictable symptoms and can occur at any time without any precipitating factors** **Usually lasts >15 minutes** Resistant to treatment (Nitroglycerin doesn’t have an effect) **Increased risk for MI and Heart arrythmias (lethal)**
119
Angina - Signs and Symptoms
Shortness of breath Fatigue Diaphoresis (increased fatigue) Weakness Women: Discomfort, crushing and pressing, bad ache Atypical: Older Adults Dyspnea Diaphoresis (Increased fatigue) Nausea Vomiting Syncope **Substernal Pain or retrosternal pain** MI Fingers clenched, middle of chest, substernal pain
120
Angina - PT Implications
Differential Diagnosis - Anterior chest wall syndrome: localized tenderness of intercostal muscles - Tietze syndrome: costochondral junction inflammation - Heartburn: Indigestion, Hiatal hernia, gallbladder, esophageal spasm, peptic ulcer, stress - Pectoralis Major/Minor Tightness
121
Nitroglycerin
Keep handy Not relieved by rest or not relieved up to three doses of NG in 10 to 15 mins (5 minutes incremental) – **Needs physician evaluation** **Promote sitting during Nitroglycerin administration – Syncope & Falls** Check expiration if NG does not produce a burning sensation under the tongue – Need to be replaced in 3 months Educate patients to follow Nitroglycerin schedule (not less or not more) **Monitor Vitals (BP, HR, and RR)**
122
What is the leading cause of death in the Unites States?
Myocardial Infarction
123
What is the best predictor of heart attack and CHF?
Best predictor of Heart Attacks (MI) - Waist to Hip Ratio Best predictor of CHF - Pulse Pressure 40 = Healthy >40 = Abnormal
124
Zones of infarction - MI
Non-contractile tissue, electrically inert Dead cells removed and fibrous scar formation
125
Transmural MI
Necrosis of entire heart tissue
126
Non-Transmural MI
Necrosis of some layers of heart tissue
127
Contraindications to exercise after MI
Acute MI (1-2 days w/o physician approval) Unstable angina ECG with abnormalities Signs and symptoms of MI Poor Oxygen saturation Hemoglobin less than 8 Acute infection
128
Right Vs Left CHF – clinical manifestations
Left: Progressive dyspnea, Frothy pink sputum, cerebral hypoxia (irritability, restlessness, confusion, impaired memory, sleep disturbances) Right: Dependent edema, JVD, Abdominal pain and distention People can have both.
129
What is this called?
Jugular venous distention
130
Dilated Cardiomyopathy - symptoms
Symptoms: Fatigue, weakness, chest pain (not like unstable angina) BP: Normal or Low
131
Hypertrophic Cardiomyopathy - Symptoms
Symptoms: Asymptomatic, exacerbated during exercise, increased left ventricular pressure, dyspnea Presenting symptom: Sudden death
132
Peripartum cardiomyopathy
Symptoms: - Orthopnea, cough, palpations, high BP - Be careful: these may not be present right after the delivery and may take several weeks after delivery (Weakness of heart)
133
Mitral Regurgitation – Clinical Manifestations
Asymptomatic to dyspnea symptoms (Orthopnea, Paryoxsmal nocturnal dyspnea) Fatigue Right Ventricular Hypertrophy Asymptomatic until irreversible left ventricular dysfunction **Exertional dyspnea (due to increased left atrial pressure)** **Exercise induced fatigue (due to decreased cardiac output)**
134
Aortic Insufficiency – Clinical Manifestations
**Wide pulse pressure (>40)** **Systolic HT** Exertional dyspnea Fatigue Angina, Palpation, Nocturnal dyspnea
135
Stenosis
Narrowing or constriction of the valve, not able to fully open due to scars or abnormal deposits on the valve leaflets Obstruction of blood flow Heart chamber must work against it
136
Regurgitation (Insufficiency)
Valves DO NOT properly or adequately close in insufficiency Backward blood flow Gradual dilation of the heart to increase cardiac output (CO)
137
Infective endocarditis - clinical manifestations
Arthralgia Myalgias Low-back pain Clubbing Splinter hemorrhages Confusion
138
Rheumatic fever and heart diseases – clinical manifestations
Sore throat (Pharyngitis) Fever Carditis - Pericardial inflammation, chest pain, mitral or aortic valve dysfunction Acute migratory polyarthritis - Occurs 2 to 3 weeks after the initial cold or sore throat Migratory arthralgia – knees, shoulder, feet, ankles, elbows, finger 24 hrs. to several weeks Chorea (Syndenham) – rapid, purposeless, repetitive movements - Less common - Occurs after 1 to 3 months of initial sore throat - Always preceded by polyarthritis - Last for weeks to years without permanent CNS impairment Shortness of Breath (SOB) Subcutaneous nodules - Bony prominences and extensor surfaces – knee, heel, arms, back of the head - Nocturnal cough - Pericarditis – pathogenesis and clinical manifestations - Most common vitals and their normal ranges – BP, oxygen saturation, RPE, HR
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What is this?
Erythema Marginatum (ring or crescent shaped) - Evanescent, non-tender, non-puritic rash in trunk and limbs
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What is this?
Pericardial Effusion - Abnormal excess fluid accumulation between the pericardial layers
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What is this?
Cardiac Tamponade - Pericardial effusion with an epigastric bulge
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Do beta blockers and calcium channel blockers change HR? In that case, how would you monitor their CV response to exercise?
Beta blockers and Ca+ will lower HR. Monitor patient with RPE.
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Exercise Considerations – Pacemakers and AICD
**Demand Pacemakers**: HR will rise with intensity of exercise **Fixed**: HR will not change - **Keep a lower limit for HR** **Automatic Implantable Cardioverter Defibrillator (AICD)** - Will deliver shock with ventricular arrythmias - **Find the HR limit for AICD** **May need to provide more than typical 5-10 minutes of cool down period** **Irregular HB**: >6 isolated HB/min - report to physician
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Pneumonia - Patho
Endotoxins from infecting organism -> Damage epithelial cells, goblet cells, and bronchial mucous glands, type II pneumocytes -> Thickening of bronchial walls with edema -> Decreased mucociliary clearance | Infection of lung parenchyma
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Pneumonia - S & S
**Sudden and sharp pleuritic pain **Hacking cough **Productive cough – rust-colored, green purulent **Decreased chest excursion on the affected side Slow and mild unnoticeable fever Complications: Pleural effusion, empyema, lung abscess
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Chronic Obstructive Pulmonary Diseases (COPD) - Def and Types (2)
Progressive airflow limitation that is not fully reversible - Chronic Bronchitis - Emphysema
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Chronic Bronchitis - Patho
Inflammation -> **Hypertrophy of goblet cells, mucosal glands, and Smooth muscle** -> Impaired ciliary function airway -> obstruction -> poor removal of secretion -> Infection => further mucus production **Distal portions affected** -> impairs alveolar ventilation, V/Q mismatch, hypoxia (cyanosis), acidosis
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Chronic Bronchitis - S & S
Persistent cough and sputum (morning and evening than midday) Prolonged expiration & wheezing SOB, reduced chest expansion Recurrent infection – fever Cyanosis Exercise intolerance
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Emphysema - Def
Enlargement of the air spaces beyond terminal bronchiole with decreased elasticity in the distal airways – airway collapse and air trapping.
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Emphysema - Patho
Air comes in and gets trapped, old air insides stops new air to come in as air is already in. Air isn't participating in the gas exchange, aka increases dead space
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Emphysema - S & S
Exertional dyspnea to dyspnea at rest Cough uncommon with little sputum (vs. Chronic bronchitis) Thin, Tachypnea, prolonged expiration, accessory muscle use Leaning forward position (diaphragm into a more domed position) Barrel chest Nocturnal hypoxemia – decreased sensitivity of chemoreceptors, decreased firing of the intercostal muscles and increased airway resistance – V/Q mismatch – Nocturnal hypoxia
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Asthma - Def
Inflammation and increased smooth muscle contraction of the airways to stimuli Reversible obstructive lung disease
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Asthma - Patho
Allergen (IgE mediated) & structural changes -> Vascular congestion Vascular permeability - Edema Mucus (tenacious) Increased bronchial smooth muscle contraction -> Impaired muco-ciliary function
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Asthma - S & S
Sensation of suffocation or chest tightness – typically the first sign *Inspiratory and expiratory wheezes *Non-productive hacking cough to tenacious sputum Emergency: SBP decreases >10 mm Hg during inspiration, tachycardia, pulsus paradoxus -> Cardiac Arrest if untreated.
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Bronchiectasis - Patho
Inflammation – enzymatic degradation of airway connective tissues
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Bronchiectasis - S & S
Foul smelling sputum, **Persistent coughing and large purulent sputum (morning worse)**
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Cystic Fibrosis - Patho
Complex and largely unknown Cl and Na channels effected, elevated
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Cystic Fibrosis - S & S
Cough Sputum Fever Weight Loss Wheezing
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TB - Latent and TB disease Patho
Mycobacterium TB, Droplet nuclei, Alveoli -> 1. Immune cells and Granuloma - (Latent TB – Not infectious and seen only in tuberculin test) 2. TB disease (active infection) – Caseating necrosis, cavity, fibrosis, and calcification of tissues
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TB - Latent and TB disease Complications
Tuberculous spondylitis (Pott Disease)
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Precautions while treating TB patients
KN95, Gloves, Disinfect Stethoscope, hand washing, yearly TB tests, isolation precautions
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Pulmonary Edema - Symptoms
- Engorged neck (Jugular vein distention) and hand veins –- peripheral edema - Severe -> pink frothy sputum Physical Therapy - High fowler position with leg dangling – reduce venous return - Monitor vitals – life threatening in few minutes
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Pulmonary Embolism - Patho
Blood clot in the pulmonary artery -- Obstruction of blood supply to the lung parenchyma Most common cause: DVT (LE – popliteal or iliofemoral (50%), deep calf veins (5%), 20% UE –subclavian vein) Most common cause of sudden death in the hospitalized population United States
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Pulmonary Embolism - Clinical Manifestations
Dyspnea (84%) Deterioration of existing dyspnea (74%) Pleuritic chest pain (74%) Apprehension (59%) Cough (53%) Tachypnea (92%)
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What would happen to FEV1/FVC ration in obstructive vs. Restrictive lung conditions?
COPD: FEV1 and FVC decreased Restrictive: FEV1/FVC remain same or slightly decreased
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Cyanosis – Where would you look for central and peripheral cyanosis?
Central – discoloration of the body & mucous membranes (Oral, lips, conjunctivae) -- Arterial saturation is decreased (Inadequate oxygen saturation (deoxyhemoglobin >5.0g/dL) & Decrease in total amount of circulating hemoglobin) Peripheral - distal extremities -- Arterial saturation may be normal -- **Decreased blood supply and perfusion than unsaturated blood**
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Atelectasis PT management – how deep breathing exercises help?
Deep breathing open the Kohn’s Pores (Connection between one aveola to another)
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Which is normal/abnormal?
Left: Normal ; Right: Abnormal
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Hemothorax
Blood in pleural space
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Pneumothorax
Air enters into pleural cavity
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Open pneumothorax
Inspiration shift left (mediastinal and trachial) Expiration shifts right (mediastinal and trachial)
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Tension pneumothorax
Try to seal over open wound over pleural cavity. Air breathed in gets stuck near seal -> building pressure
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Pericardial effusion vs pleural effusion
Pericardial effusion Buildup of fluid around the heart. Pleural effusion a collection of fluid in the pleural space between the membrane encasing the lung and the chest cavity
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Pleural rub vs. Pericardial rub characteristics
**Pleural rub creates pain mostly on the lateral part of the chest wall, whereas pain due to pericardial rub is always central in location**. The intensity of pleural rub is increased on pressing the diaphragm of the stethoscope over the affected area, whereas there is no such change in case of a pericardial rub. **Cessation of sounds with holding breath (vs. Pericardial friction rub)**
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Exercises for restrictive lung disease
Monitor Vitals Constitutional Symptoms Bilateral UE D2 Flexion to improve chest wall movement in restrictive lung disease Pursed Lip breathing/deep breathing
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O2 Stat Values
Normal 95-100% Low 90-94% Supplemental O2 req’d <90%
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Osteoporosis
Postmenopausal (Primary, Type 1) - **Decreased Estrogen** -> - Increased Osteoclast activity and Decreased apoptosis -> - Increased bone resorption Senile Osteoporosis (type II/Secondary): - **Decline in Alpha 1- hydroxylase activity in the kidney** -> - **decline in serum 1,25-dihydroxyvitamin D (1, 25 (OH) 2D)** -> - **malabsorption of calcium and secondary hyperparathyroidism** -> - **Bone resorption** T Score of -2.5 and lower
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Osteopenia
Low Bone Mass T: Score: -1.0 and -2.5
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Osteomalacia
Impaired bone mineralization
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Osteomalacia - Patho
- Vit. D Deficiency - Renal Osteodystrophy -- (CKD, <60 mL/min GFR)
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Osteomalacia is called what in children?
Rickets
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Signs and Symptoms: Osteomalcia
Subtle – delayed diagnosis Diffuse bone pain and tenderness
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Paget's Disease - S & S
* Asymptomatic * Pain – itself or arthritis in knee or hip * Skull – Enlargement leads to headache, dizziness, hearing loss * Spine- tingling and pinched nerves * Lower Legs – bowlegs and difficulty in walking Possibility of Heart Failure Def: New bone gradually regrow onto old bone
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Paget's Disease - Heart Failure
due to increased work for heart to supply blood to the newly formed bones
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Osgood Schlatters Disease
Pulling of small bits of immature bone from tibial tuberosity
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Osgood Schlatter Disease - S & S
-Increased Q angle – knock knees/flat foot - Patella Alta (high patella) -- Patella tracking affected; Patella gets pulled up by quadriceps tendon when the ischial tuberosity breaks off. - Pain -- Flexion moment – increased stress on the tibial tubercle - Minor stretching is okay, NOT aggressive
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What is this called?
Osgood Schlatter Disease
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Osteomyelitis - Pathogenesis
- Inflammation of the bone by infection – Bacterial, Fungus, parasites and viral - Staphylococcus Aureus
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Osteomyelitis - How do children get it?
Sharp turn of vasculature leads to blood slowing down. Results in microabscess occuring at this location.
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Osteomyelitis - Why do adults not get this as much?
Rare as adults do not have same blood supply
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Osteomyelitis - When to refer?
Refer patient if they have pus or if they do not have medication. Easier to treat because of more blood circulation.
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Osteomyeltiis Clinical Manifestation - Children
Unexplained cellulitis (painful skin infection with swelling and warmth)
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Osteomyelitis - Acute OM
- Low grade fever – systemic - Pain – intermittment/constant/deep -- Aggravated with activity (increases with weight bearing) -- Periosteum – rapid development of pain, fever, swelling - Spine and Abcess – rigidity, instability -- Psoas abcess – painful hip extension (antalgic gait) -- Myelopathy, Meningitis
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Osteomyelitis - Chronic OM
- Local pain, swelling, limping - **Sausage Toe – Good sensitivity and specificity in diabetes**
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What is this called?
Osteomyelitis
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Avascular necrosis - which movements are affected
AROM pain – hip internal rotation and flexion and adduction
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Legg-calve-perthes disease - which movements are affected
AROM limitation in hip abduction and rotation (Internal rotation)
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OA - Pathogenesis
Wear and Tear – Passive process Active process - Matric Metablloproteinases and cyotkines lead to loss of type 2 collagen -> Catabolic degredation of cartilage -> reduced frictionless movements
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OA Management
Pharmalogical: NSAIDs Surgical Walking
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What activities and exercises are strongly recommended for OA management according to 2019 guidelines?
Walking
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Gout
Uric acid crystalizes (mono sodium urate crystal – MSU)
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Gout - S & S
*Tophi – Subcutaneous nodules of sodium urate crystal (In image) *Fewer *Chills *Malaise *Pain – Intense “on fire” *Swelling
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Sprain and Stain – degrees
*First degree (mildest) – **little tearing**, pain or swelling; **joint stability is good**. *Second degree – broadest range of damage, with **moderate instability** and moderate to severe pain and swelling. *Third degree (most severe) – ligament is **completely ruptured; joint is unstable**; severe pain and swelling; other tissues are often damaged
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Osteochondritis Dissecans
Repetitive stress -> Ischemia and subchondral growth cessation -> Necrosis -> Articular cartilage softening -> Fragment seperation
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What is this?
Osteochondritis Dissecans
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Muscular dystrophy – Gowers sign and PT exercise modifications
Gowers sign -Lumbar lordosis -Toe walking – calf, anterior tibial, peroneal -**Pseudohypertrophy of calf muscles** -Scoliosis PT Exercise Modifications -**No strenuous exercise -Low weight, high repitions -Encourage mobility**
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Most common muscles weakness associated with muscular dystrophy
Lumbar and gluteal muscles
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Rhabdmyolysis - Patho
Muscle damage - Myoglobin -> block kidney-> Kidney failure Statin Induced Myopathy (cholesterol medication control – statin; Ex: Prozac)
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Rhabdomyolysis - S & S
Tea colored or cola colored urine
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Rhabdomyolitis - Exercise Modifications
Allow for athletes to properly hydrate when exercising at a high intensity especially when it is hot out to help prevent dehydration. Exercise induced muscle damage can be a sign for rhabdomyolysis be careful.
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Myositis Ossificans - PT Implications
Contraindication: - Aggressive Stretching Allowed: - Passive and active movements and strengthening
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What is this?
Myositis Ossificans
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DOMS and EIMD – Exercise modifications
New exercise during training - Progressive approach of exercise in 1 to 2 weeks Delayed Onset of Muscle Soreness (DOMS) - 24 to 48 hours Exercise Induced Msucle Damage (EIMD) - Inflammatory markers of muscle damage - inflammation
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Hypothyroidism - Patho
**Iodine Deficiency** or Inflammation/Hashimoto’s Thyroiditis -> Reduced functional thyroid gland -> **Decreased T3 and T4** -> Hypersecretion of TSH (Due to little T3, T4 because of no iodine) -> Large production of Thyroglobulin (colloid) -> **Glandular enlargement (Colloid Goiter)**
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Hypothyroidism - S & S
* Weight gain due to decreased lip metabolism * Fatigue and increased sleep (Due to no energy conversion) * Prolonged DTR (especially Achilles) * Bradycardia * Myxedema * Constipation
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Hyperthyroidism - Patho
Graves Disease (85%), adenoma, thyroid cancer GD Increases grandular size -> Increases synthesize of thyroid hormone -> - Increased T3 and T4 Results in Goiter
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Hyperthyroidism - S & S
Myopathy – difficulty ambulaating, stairs, raising from chair Heat intolerance Diarrhea Weight loss Tremor Increased DTR Atrial fibrillation Exophthalmos – Protriding eyes Hair loss
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Hyperthyroidism Acute flareup
Can be life threatening * Fever * Severe tachycardia * Delirum * Dehydration * extreme irritability
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What is goiter, grave’s disease, and exophthalmos?
Goiter - Glandular enlargement (Colloid Goiter) Grave’s Disease - Autoimmune Disease Exophthalmos - Protruding Eyes - Lots of fluid on the backside of the eye
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What is this?
Exophthalmos
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Would you do exercise when someone has exophthalmos?
No! Document and refer! This can lead to stroke.
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Hyperparathyroidism
Excess Calcium in the blood (binded to phospate) - Osteoclastic activity -> osteoporosis and fractures - High Ca+ in renal tubules – Nephrocalcinosis (kidney disease) - stone formation Decreased Vitamin D, leads to less Calcium absorption
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Hyperparathyroidism - Clinical Manifestations
Mild to severe proximal muscle weakness of the extremities Muscle atrophy
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Cushing's Syndrome - PT Implications
Excess Cortisol * Stength Training – Large Groups (Avoid extreme stress) * Education on proper body mechanics * Jogging is not recommended * Manipulation – Caution (Bones are weak)
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What is this?
Cushing's Syndrome
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Fluid imbalance – dehydration signs and symptoms
Fluid Deficit – loss of fluids (hemorrhage, burns, diarrhea, diaphoresism vomiting) -Poor skin turgor -Weight loss -Dryness of mouth, throat, face and absense of sweat - thirst
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Actions – Glucose and Insulin
Glucose: Provide energy for cells: muscle, fat, liver and brain. Insulin: Allows for glucose to be utilized by opening channels
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Type 1 DM - Patho
* Auto-immune disease (Type 4 HS) * Beta Cell destruction in pancreas * No insulin production (absolute insulin deficiency) * Ketoacidosis (Excess ketones create metabolic acidosis)
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Type II DM - Patho
Normal or excess insulin production Reduced number and function of insulin receptors – insulin resistance - Increase blood glucose, cell’s don’t receive glucose
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Hypoglycermia - Cardinal Signs
Rapid onset (minutes) - Hypoglycemia Difficulty concentrating, speaking, focusing Shaky Shallow respiration
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Hyperglycemia - Cardinal Signs
Gradual (days) - Hyperglycemia Lethargic Confused Thirsty Dry
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Dupuytren contracture
More common in type 1 than type 2 Flexion contracture, **nodules** (distal palmar crease), thickening cord of palmar fascia – usually **third and fourth digits**
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What is this?
Dupuytren contracture
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Diabetic ketoacidosis
* Blood glucose >300 mg/dL (250-300 is caution) * Thirst (very dry mouth) * Hyperventilation * Fruity odor breath * Confusion * Dehydration * Arterial pH <7.30
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Insulin shock
* Blood Glucose <70 mg/dL * Perspiration * Irritability/nervousness * Weakness * Hunger * Fatigue * Numbness or lips/tongue
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DM - Blood Glucose Levels
Safe Zone: 100-250 mg/dL Goal: Type 1: 90 to 130 Type 2: Up to 150 250-300: CAUTION
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DM - PT Implications
Encourage fluid intake before exercise Exercise after 1 hour of a meal Do not exercise without a meal for 2 hours Do not inject short acting insulin to the site for 1 hour after exercise – quick absorption Monitor glucose before and after exercise - BG decrease when doing strength training - Cardio – Only for heart, oxidative system
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Sickle Cell Disease - S & S
Anemia Severe infection Headache Enlarged organs Acute episode of SCD - Hand foot syndrome (painful swelling of hands and feet)
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Anemia - PT Implications
Hemoglobin - <8 g/dL Symptom based approach (monitor vitals especially Spo2) - <5-7 g/dL (low critical value – HF or death) Hematocrit - Male: 42-52% - Female: 37-47% - <25% symptoms based approach Use RPE and gradually increase exercise – poor exercise tolerance Very careful when using cold - Cold increases VC and sickling – contraindication for SCD
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Anemia - S & S
Fatigue and weakness with minimal exertion Bleeding – gums, mucous membranes, skin
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Thrombocytopenia
Decreased platelets – increases likelihood for bleeding
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Thrombocytopenia - S & S
Mucosal bleeding – brushing teeth Respiratory tract – blowing nose Uterus – excessive menstrual bleeding Brain – external hematoma
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Thrombocytopenia - PT Implications
Bleeding? Apply ice and pressure No strenuous exercise allowed Blood pressure cuff – CAUTION (Give LOTS of time in between each measure) Mechanical compression and pneumatic pump – contraindicated Keep eye on aspirin intake – need physician approval <20 k/uL: Symptom based approach 20,000 - 40,000: Low intensity exercise with no weight or resistance up to 2 lbs - No resistance during statioonary biking 10,000: Spontaneous CNS, Respiratory tract, and GI bleeding Ambulation precautions – get clearance from the healthcare team for ambulation
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Leukemia S & S - Acute and Chronic
Acute * Spontaneous bleeding – skin and mucosal surfaces * Mid-cycle menstrual bleeding or heavy menstrual bleeding * Leukemia cutis – infiltration of the cancer cells to skin Chronic * Nonspecific * Weight loss * Splenomegaly (Left upper quadrant pain) * Chronic to acute leukemia and die within months
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What is this?
Leukemia
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Lymphoma - S & S
Drenching night sweats Unexplained weight loss (>10% of BW) over six months Unexplained fever Enlarged Lymph nodes
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Polycythemia Vera
Neoplasm of bone marrow -> Increased RBC production
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Leukemia
Neoplasm of WBC Infiltration and spread to blood stream and organs
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Multiple Myeloma
Primary malignant neoplasm of plasma cells Second most common hematologic cancer
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Lymphoma
Neoplasm of the lymphatic system Hodgkins Lymphoma - Upper body - Reed-Sternberg Cell Non-Hodgkin's Lymphoma - Abdomen, groin - More common, poor prognosis
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Malignant Melanoma
Neoplasm of the skin (Melanocytes – synthesize melanin) cells
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Normal and abnormal lymph node identification
Normal: soft, rubbery, mobile, small (<1cm) Abnormal: Tender, warm, enlarged (but mobile and soft) Malignant: Enlarged, hard, non-tender or non-mobile
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Dermatitis vs. cellulitis
Dematitis: Eczema - Contact dermatitis Cellulitis – Infection - Rashes often with pain and fever Caution with redness due to orthotics and prothetics
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What happens to Calcium absorption, Vit. D, Phosphorus, Parathyroid hormone, Calcitonin levels in Osteoporosis and Hyperparathyroidism?
Parathyroid hormone increase Activate Osteoclasts break down bone Ca and phosphorus comes out od bone (free calcium) Ca has high tendensy to attach to phosphorus but in blood stream is low Leads to more PTH to break things down more because low in blood. Total calcium level is elevated in this test – calcium level is high Total phosphorus level is high PTH is high Vitamin D deficiency leads to no absorption of Ca from interstine. Calcitonin is the opposite of PTH don’t have strong evidence what happens with interactions of these other minerals.
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What do cancer cells secrete?
PTH like hormone