Final Flashcards
Definition of vitamin
Chemical in food required for growth and health
A great way to get enough vitamins in your diet is:
eating 5 or more servings of fruits and vegetables a day
What is Rickets?
- Smoke and coal in sky absorbed UV portion of sunlight needed for vitamin D
- 90% of children in Boston and Parts of Europe had rickets in 1880-1920 (industrial revolution)
- Causes bone to form incorrectly
Beri Beri is a deficiency in___
- Thiamin
- Japanese navy who only had rice, not in navy that got beans, barley, and meat
- lethargy, fatigue, Cardio, nervous, muscular, GI complications
Pellagra is a deficiency in_____
Niacin
-Dermatitis, Diarrhea, Dementia
-1900s, southeastern USA corn mush because cotton economy failure. Niacin in corn is not well absorbed
7000 deaths per year
Vitamin A deficiency causes
- Blindness
- Diarrhea
- Found in dark greens, deep oranges
- Pre formed vitamin A retinol in Animal Products with fat (meat, fish)
What deficiency will cause a goiter
Iodine
- needed for production of thyroid hormone
- Deficiency in pregnancy can lead to intellectual disabilities
- 30% of world at risk of iodine deficiency
What are examples of water-soluble vitamins?
Describe how they’re stored in body. What are problems associated with them?
B and C
-Easily destroyed in food storage and prep.
Typically they “wash out” of body in a few days because water soluble ->B12 can be stored for up to a year in the liver
-B6 and C dangerous at high dose -> Megadose will stress kidney
4 ways to minimize nutrient losses
1: refrigerate fruits and vegetables
2: to minimize oxidation, reduce air contact
3: wash before cutting now after
4: avoid cooking at high temps for long time, steam or stir fry is better
5 places to get Folic Acid
- Leafy green vegetables
- Legumes
- Liver
- Lentils
- Fortified grain products
(synthetic folic acid is More Bioavailable then natural food sources)
3 Folate/ folic acid deficiency problems
1- deficiency causes DNA instability, increases carcinogenesis
2- Heart health-> homocysteine accumulates in blood so Heart attack and stroke
3- Fetal Health, neural tube defect
5 things that Vitamin C does
1-Antioxidant
2-Cofactor in collagen formation
3- Cofactor in other reactions like: tryptophan-> serotonin and norepinephrine; Fatty acids transport into mitochondria for energy metabolism; hormone production (thyroxine)
4- Stresses like: infections, burns, extreme temps, toxic heavy metals, chronic aspirin, barbiturates (sedatives), oral contraceptives, cigarette smoking -> vitamin C is released with stress hormones in response to these
5- Common Cold can be reduced by 1 day/ 23% if 1g/day vitamin C taken. Also reduces blood histamine with 2g/ day over two weeks
How much vitamin C needed?
10mg prevent scurvy
-100mg saturate body pool
-DRI women: 75mg/d; men: 90mg/d
Excess-> nausea, abdominal cramps, excessive gas, diarrhea
Vitamin D roles in body
1- bone growth: ^ Ca and P in blood… ^intestine absorption…^kidney reabsorption… mobilization from bones into blood
2-Cancer: breast, prostate, colon decreased chance
3-Multiple sclerosis; rheumatoid arthritis: ^37º latitude = >100% ^ in MS. BUT 400IU/day lowers MS risk by 40%
UVB produces vitamin D, what are dietary ways to get vitamin D?
- fortified dairy foods
- fortified margarine
- fish oils
- egg yolk
- fluid milk is best source
Who is at higher risk of Vitamin D deficiency
- 70yrs and older have 30% less Vitamin D production then younger adults
- institutionalized individuals
Definition of phytochemical
-Biologically active compound in plants that offer resistance to chronic disease
what does a phytochemical do in Plants?
- Give pigmentation and flavor
- promote chemical reactions/ used in metabolism
- protect from bacteria , fungi, animals and environmental oxidants
Are phytochemicals essential?
- not essential
- they do not have deficiency symptoms
- antioxidant properties good for tissues
- some are toxic… too much is not better
illness that phytochemicals protect against
- Cancer
- Heart disease
- high blood pressure
- other chronic diseases
What do phytochemicals do in the body
- Antioxidants
- Hormonal action
- stimulation of enzymes
- interference with DNA replication
- Anti-bacterial effect
- Physical action
Things about tomato phytochemical: Carotenoids
- Antioxidants
- > neutralize free radical cell damage
- > therefore may reduce cancer risk (prostate)
-2 main carotenoids
beta-carotene (carrots)
lycopene (tomatoes)
Things about Phytochemical Flavonoids:
- Act as antioxidants
- anti-inflammatory
- reduce plaque buildup
- deactivate carcinogens
Found in Berries and black/green tea
Things about the phytochemical Indoles
- May alter estrogen action to reduce breast cancer risk
- neutralize free radicals
- Cruciferous Vegetables
Things about the phytochemicals Tannins
-Act as antioxidants
Inhibit cancer activation and promotion
-May prevent early atherosclerosis
Found in GRAPES, RED/WHITE WINE
What is Solanine
Green potato
harmful plant components that is natural to fight against insects and fungi
will cause: Diarrhea, vomiting, fever, headache, paralysis
What is Oxalic acid
harmful plant component
- from turnip greens, spinach, rhubarb
- can bind to calcium and irritate the stomach and cause kidney stones
What are phytates
harmful plant components
found in whole grains and bind to minerals
What are Aflatoxins
from Aspergillus fungi
- growing on nuts and nut products, dried foods, grains, spices and cocoa beans,
- which cause liver cancer.
- Testing done by CFIA.
- Discard nuts that look moldy, discolored or shriveled.
What is Selective breading
-selectively breeding crops & animals for centuries
-examples
: wild, native corn = 5 kernels/stalk
: super-sweet corn
: leaner animals
: chickens used to lay 50 eggs/year today they lay 245 eggs/year
Benefits to GMO
1) Extended Shelf Life
- tomatoes stay firm & ripe longer
- “antisense” (mirror image) gene
- binds to native gene and prevents synthesis of softening protein
- harvested at more flavorful, nutritious vine-ripe stage
2) Efficient Food Processing
* rennin - coagulate milk in cheese production
* traditionally from calf stomach
* today mass produced in bacteria
* save time, money & space
* in the future: lactose free milk? : decaf coffee bean?
3) Biopharming
* use animals & plants to produce drugs
- cow produce vaccine in milk
- bananas & potatoes to make vaccines
- hydroponically grow tomato plants to secrete protein through roots into water
4) Improved Nutrient Composition
* soybeans: upgrade protein quality
* canola: increase monounsaturated fatty acids
* “golden rice”: genes from daffodil & bacteria to make beta-carotene
5) Genetically Assisted Agriculture
* 90-95% of canola crops in Canada are GM to withstand herbicides (not just for food, lip gloss, soap, others)
* farmer can spray whole field, kill weeds & not harm canola
* soy, corn, sugar beets, potato, alfalfa (and 80% of Hawaiian papayas)
Main Issues of concern for human Health related to GMOs
1) Allergenicity: making one food have the allergy properties of another. Not currently backed by science
2) Gene Transfer: Genes moving from food to the body or GI bacteria
3) Outcrossing: worry that seeds could blow between crops mixing GMO crops with conventional crops
Leading causes of death: cancer
Men: Lung 32%, Colon & Rectum 9%, Prostate 14%
Women: Lung 25%, Colon & Rectum 10% ,Breast 16%
four stages of Cancer
1) Initiation- carcinogen-> permanent genetic change
2) Promotion - compounds cause the initiated cells to divide and accumulate
3) Progression - fast increase in tumor size and cells can undergo further mutations with metastatic potential
4) Metastasis - invade surrounding tissues and/or spread
3 Factors affecting Cancer Development that aren’t food related
- Genetics
- Immune Factors: aging, decline in immune system, immunosuppressive drugs and viral infections
- enviro exposure
Dietary factors influencing cancer risk- INITIATORS
carcinogens: pesticides, nitrosamines (naturally occurring in beer and scotch formation) and linked to stomach espophagus liver and bladder cancer
classes of carcinogens
Group 1 Carcinogenic to humans
group 2A Probably carcinogenic to humans
Group 2B Possibly Carcinogenic to humans
Group 3 Unclassifiable as to carcinogenicity in humans
Group 4 Probably not carcinogenic to humans
Dietary factors influencing cancer risk- Promoters
- accelerate tumor development once initiating step has occurred
- “lag time” of 10-30 years
- excess dietary fat by contributing to obesity
- omega-6 fatty acids promoters in some animals
Fats effect on cancer
- can oxidize at high cooking temperatures, possibly producing oxidative stress
- oils become oxidized over time
- fat stimulates bile secretion, bacteria can convert bile to cancer-causing compounds
Dietary factors influencing cancer risk- Antipromoters
- high fruits & vegetables and cancer risk
- fiber protective against colon cancer
- phytochemicals -> cruciferous vegetables
Recommendations for Reducing Cancer Risk
1) Choose diet rich in a variety of plant-based foods
- >7 servings of whole grains, legumes, starchy vegetables
- 5-10 servings of other vegetables & fruit
- limit processed foods & refined sugar
2) Maintain healthy weight and be active
- avoid under & overweight
- 1 hour of exercise daily
3) Drink alcohol in moderation, if at all
- limit 2 drinks/day men; 1 drink/day women
4) Prepare and store foods safely
- do not eat charred food
- consume meat/fish grilled in direct flame only occasionally
5) Select foods low in fat and salt
- limit fatty foods especially of animal origin
- limit red meat to 3 portions per week
- modest amount of vegetable oil
- limit salted foods & table salt (salt-preserved foods damage stomach lining)
6) And most important of all: Do not smoke or use tobacco in any form
Factors associated with site specific cancers
- Stomach: salt-preserved foods; possibly grilling & BBQing
- Colorectal: saturated fat, red meat, alcohol; possibly grilling
- Liver: hepatitis B, alcohol
- Lung: smoking; possibly alcohol, saturated fat, cholesterol
- Breast: obesity, early puberty, alcohol; possibly meat & fat
- Prostate: high fat intake (especially from meat)
What are heterocyclic amines how do they form
- Charring, burning or grilling meat, poultry and fish over high temperatures causes heterocyclic amines (HCAs) to form. HCAs are mutagenic.
- do not burn food when cooking by any method
- marinating meats can help reduce carcinogen formation
- trim the fat (fat dripping into heat produces harmful smoke that coats the food)
- lower the temperature
how many essential minerals are there
15
a deficiency in one or more will cause a chronic disease
Function of mineral charge
– Helps maintain an adequate amount of water in the body
– Assists in neutralizing acidic or basic body fluids
– Minerals are components of proteins and enzymes
- source of electrical power to stimulate muscle contraction and nerve reaction
-are part of bone, teeth, cartilage, other tissue
Positive charge + negative charge = formation of stable compound
Calcium: roles, sources, storage in body
• ~99% is stored in our bones and teeth • ~1% is in our blood, muscle and other body fluids • Important for – Muscle contraction – Blood clotting – Cell membrane integrity – Nerve conduction – Strong bones and teeth
Milk & milk products • Fish bones • Tofu • Greens (Kale, Bok choy) • Legumes
Oxalic acid and Phytates affect on Calcium Bioavailability
Oxalic acid, found in spinach, beets, celery, pecans, peanuts, tea and cocoa, can bind to calcium and form an insoluble complex that is excreted in the feces.
Phytates, found in whole grains, legumes, and nuts, can bind to calcium to form an insoluble complex, thereby decreasing the absorption of calcium
calcium supplements
- Purified calcium
– Carbonate (most common: best with meals), citrate (good for elderly: doesn’t require gastric acid), gluconate, lactate or phosphate - Calcium mixtures
– magnesium, vitamin D, zinc - Powdered calcium
– Caution: bone meal, oyster shell, dolomite
***Iron chelates with calcium so don’t take at same time!
What three mineral deficiencies form osteoporosis
Calcium, Phosphorus, Vitamin D
age of peak bone mass
30yrs
at menopause bone calcium deteriorates
High bone mass when you’re young sets you up for higher chance of good bones through life
Risk Factors for osteoporosis
- Female
- Menopause
- Low Ca intake
- White or Asian
- Thinness
- Smoking
- Excessive alcohol
- Inactivity
- Genetic
- Low vitamin D
Best sources of Iron
- Liver
- Beef
- Prune juice
- Dried fruit
- Beans & lentils
- Cereal
- Cream of wheat
- Oatmeal
- Dry cereal
Where is Iron stored in body
Hemoglobin (oxygen transport protein)
-Some stored in Myoglobin (storage/transport of oxygen in muscle cells)
Heme vs Non Heme iron and absorption
- Non heme not as well absorbed because tight bond to oxalate, phytate, tannins
- Can be improved by vitamin C
- Absorption is worse with tea, coffee, Calcium & phosphorus, Phytates, tannins, & fiber
DRI iron
8mg/day men
18mg/day women
(15mg = ~2500kcal)
How common is iron deficiency?
how is iron deficiency caused?
Low intake or Blood loss through: –Menstruation –Injury –Surgery –Ulcers –Blood donation
5% of Canadians, and 25% world population
Symptoms of Iron Deficiency: Anemia
Exhaustion • Paleness • Short attention span • Irritability • Susceptibility to infection • Rapid heart rate In infants and children, deficiency anemia may cause irreversible impairments in mental development
Iron Overdose
Leading cause of accidental poisoning in young children
Alcohol increases iron absorption
Iron toxicity causes liver damage, diabetes, heart failure
The silent killer and stats
Hypertension (induced by high sodium intake)
135/85 is 2x as likely to get heart attack as 115/75
people who are overweight are 6x greater risk of hypertension
Definition of a supplement
Called Natural Health Products by Health Canada and
include:– Probiotics– Herbal remedies– Vitamins and minerals– Homeopathic medicines– Traditional medicines such as traditional Chinese
medicines– Other products like amino acids and essential fatty acids
What is USP for multivitamin?
should take multivitamin with a meal
-U.S. Pharmacopeia)- The USP Dietary Supplement Verification Program
is a voluntary program open to manufacturers of
dietary supplement finished products from around the
world, ensures that:
1) Contains what it claims
2) No harmful levels of contaminants (like lead)
will break down and release into body within proper amt of time
3) was made according to
4) FDA manufacturing standards
How to properly take iron supplement
- with meal or glass of juice- avoid taking with tea or coffee- if anemic, not at same time as Ca