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Cancer Biology > Final > Flashcards

Final Flashcards

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0
Q

Cytoreduction

A

Kill/remove as many cells as possible

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1
Q

Cancer treatments

A
  1. Surgery
  2. Radiation therapy
  3. Drug therapy
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2
Q

Resection

A

Physical removal of tumor

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3
Q

Whipple Procedure

A

Surgery for pancreatic cancer.

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4
Q

Brachytherapy

A

Isotopes placed in body at tumor site. Prostate cancer

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5
Q

External beam therapy

A

Radiation aimed at tumor site

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6
Q

Boron-neutron capture therapy

A

Neutron is shot at boron that accumulates in the cells

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7
Q

Tumors treatable by radiotherapy

A

Hodgkin’s lymphoma
Non HL
Nasopharyngeal
Testicular

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8
Q

Chemotherapy effectiveness response level

A
  1. Complete response
  2. Partial response
  3. Stable/ Remission
  4. Progression
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9
Q

Platinum drugs

A

Carboplatin- ovarian and lung

Oxaliplatin- CRC

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10
Q

Nitrogen Mustard

A

First chemotherapy

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11
Q

Nitroso-ureas

A

Inhibit translation. Kills alkylating agent resistant tumors

Carmustine Lomustine Streptozocin

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12
Q

Alkylating agents

A 
Temozolamide
Thiotepa
Altretamine
Decarbazine
Procarbazine
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13
Q

Antibiotics from Streptomyces

A

Anthracyclins
Actinomycin D
Bleomycin
Mitomycin

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14
Q

Anthracyclines

A

Cardio toxic

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15
Q

Mitoxantrone

A

Semisynthetic anthracyclines

16
Q

Actinomycin D

A

Inhibit RNA synthesis

17
Q

Bleomycin

A

Breaks DNA

18
Q

Mitomycin

A

Cross links DNA

19
Q

Plan alkaloid from yew trees

A

Taxanes: microtubule poisons

Taxol
Docetaxel

20
Q

Ixabepilone

A

Works like taxanes. Derived from myxobacterium

21
Q

Plant alkaloid from periwinkles

A

Vinca alkaloids: neurotoxic!!!!!
Vincristine
Vinoblastine

22
Q

Folfiri

A

Folinic acid
Fluoro-uracil
Irinotecan

23
Q

Fluoro-uracil

A

Nucleotide synthesis inhibitors

Gastrointestinal toxicity

24
Q

ATRA

A

Treat APL. From a Chinese folk remedy

25
Q

Tamoxifen

A

Estrogen antagonist

26
Q

Exemestane

A

Mimics androgens

27
Q

Fulvestrant

A

Down regulates estrogen receptors

28
Q

Triptorelin

A

Suppress testosterone production

29
Q

Bicalutamide

A

Testosterone antagonist

30
Q

Glucocorticoid

A

White blood cell suppressive

31
Q

Schedule dependent drugs

A

Affect only one phase of cell cycle

32
Q

Schedule independent drugs

A

Cause long lasting chemical modifications. Cell death when they attempt division

33
Q

Drugs that affect S phase

A

Daunomycin. Ara-c

34
Q

Drugs that affect G1/M

A

Taxol

Cancer Biology (1 decks)

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