Final Flashcards

1
Q

Adverse Effects

Glucocorticoid - prednisone

A

Suppression of adrenal function, hyperglycemia, myopathy, peptic ulcer disease, gastrointestinal discomfort, infection, fluid and electrolyte imbalances, fat redistribution (long term therapy), bone loss, cataracts (long term therapy)

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2
Q

Therapeutic Use

Opioid Antagonist - naloxone

A

Reversal of opioid effects (overdose)
Reversal of neonatal respiratory depression (from maternal analgesics)
Treatment of opioid abuse by preventing euphoria (naltrexone)
Reversal of severe opioid-caused constipation in clients who have late stage cancer or other disorders

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3
Q

What are the most important vital signs to assess before administration of opioid agonists?

A

Respirations

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4
Q

Adverse Effects

Opioid Agonist - morphine

A
Respiratory depression
Sedation, dizziness, lightheadedness, drowsiness
Constipation
Nausea, vomiting
Orthostatic hypotension
Urinary retention
Cough suppression
Potential for abuse with tolerance and cross-tolerance with other opioids (larger dose required for usual effect)
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5
Q

Contraindications

COX-2 Inhibitor - celecixib

A
Pregnancy risk (third trimester) - can cause premature closure of ductus arteriosus
Severe hepatic impairment, advanced kidney disease, children younger than 18 years old, GI bleeding, anemia, pain from coronary artery bypass grafting, allergy to sulfa, sulfonamides
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6
Q

Therapeutic Use

Antigout - allopurinol

A

Hyperuricemia due to chronic tophaceous gout, cancer chemotherapy, and some blood dyscrasias

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7
Q

Adverse Effects

Nonopioid Analgesic - acetaminophen

A
Liver damage (overdose)
Hypertension (with daily use, particularly women)
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8
Q

Therapeutic Use

NSAID - aspirin

A
Inflammation suppression
Analgesia for mild to moderate pain
Fever reduction
Dysmenorrhea
Inhibition of platelet aggregation
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9
Q

Nursing Interventions

Methylphenidate - methylphenidate hydrochloride

A

Give doses early in day to allow for nighttime sleep
Monitor height and weight
Drug “holidays” may help prevent growth suppression
Monitor vital signs
Monitor use of this drug carefully
Taper dose when discontinuing drug
Monitor for signs of depression, fatigue when drug is stopped

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10
Q

Therapeutic Use

Centrally Acting Muscle Relaxant - baclofen

A

Relieves skeletal muscle spasms in: spinal cord injury, multiple sclerosis, cerebral palsy

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11
Q

Adverse Effects

Hydantoin - phenytoin

A
Drowsiness and other CNS effects
Gingival hyperplasia (abnormal growth of tissues around gums)
Skin rash (epidermal necrolysis, Stevens-Johnson syndrome)
Withdrawal symptoms following long-term use (seizures)
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12
Q

Contraindications

Hydantoin - phenytoin

A

Pregnancy risk: teratogenic

Skin rash, bradycardia or heart block, previous allergy to hydantoins, seizures caused by low blood sugar

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13
Q

Adverse Effects

Benzodiazepines - midazolam

A

Amnesia (memory loss from prior to injection)

Cardiac or respiratory arrest

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14
Q

Pharmacological Action

Dopamine Replacement Drug - levodopa/carbidopa

A

Dopamine-replacement drugs work because they can cross the blood-brain barrier, where they are then taken up by the remaining dopaminergic neurons in the substantia nigra. The drug then converts to dopamine in these neurons and is available for use. Carbidopa augments levodopa by decreasing the amount of levodopa that converts to dopamine in the intestines and periphery. This results in greater amounts of levodopa reaching the CNS

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15
Q

Therapeutic Use

Serotonin Agonist - sumatripan

A

Relieve symptoms of existing migraine or cluster headache

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16
Q

Client Education

MAO-B Inhibitors - selegiline

A

Instruct client to take last dose of the day by noon to prevent insomnia
Instruct client to notify provider before taking any new drugs
Instruct client about foods to avoid
Inform client of drugs, including herbals, which may interact with selegiline
Instruct client to report irritation to provider

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17
Q

Adverse Effects

SSRIs

A

Insomnia, nervousness
Sexual dysfunction
Headache
Weight gain
Hyponatremia (especially in older adults and those taking diuretics)
Increased risk for suicidal ideation (especially young adults)
Serotonin syndrome

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18
Q

Interactions

SNRI - venlafaxine

A

Taking SNRIs within 14 days of MAOIs increases the risk of serotonin syndrome
Cimetidine (tagament), desipramine (Norpramin), and haloperidol (Haldol) increase blood levels of venlafaxine
Trazodone (Desyrel), St. Johns Wort, and sour date nut increases the risk of serotonin syndrome

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19
Q

What labs should be monitored when a patient is on lithium?

A

Monitor lithium serum levels (should be below 1.0 mEq/L)

Monitor sodium levels

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20
Q

Contraindications

Tetracyclines

A
Pregnancy risk - teratogenic
Children younger than 8 years old
Allergy to tetracyclines
Exposure to ultraviolet light
Serious renal or liver failure
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21
Q

Adverse Effects

Aminoglycosides - gentamicin

A

Elevated trough levels of drug (early signs include tinnitus, headache, and vertigo) can cause ototoxicity
Nephrotoxicity (polyuria, dilute urine, protein and casts in urine, elevated BUN, creatinine)
Ataxia

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22
Q

What is the suffix for fluroquinolones?

A

-floxacin

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23
Q

Interactions

Fluoroquinolones - ciprofloxacin

A

Antacids, iron preparation, calcium (including dairy products), and sucralafate (Carafate) decreases oral absorption
Increase theophylline levels and the risk for CNS symptoms
Increase warfarin (Coumadin) levels
Concurrent use of erythromycin, quinidine, some antipsychotics, and tricyclic antidepressants can increase the risk for torsade de pointes in those susceptible
Increase hypoglycemia may occur when taken concurrently with antidiabetic medications

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24
Q

Adverse Effects

Antiviral - acyclovir

A

Topical form: burning, itching at application site (usually temporary)
Oral: GI symptoms (nausea/vomiting, diarrhea, headache, vertigo)
IV: Renal toxicity, CNS toxicity (rare; clients with renal impairment are at most risk), restlessness, tremors, psychosis, seizures, thrombophlebitis at IV site, IV infiltration causes damage

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25
Adverse Effects | Anti-tubercular - isoniazid
Liver damage, including hepatitis, liver failure (especially common in older adults and clients with alcohol use disorder) Peripheral neuropathy: numbness, tingling, pain in the hands or feet (especially common in clients who have diabetes or alcohol use disorder) CNS symptoms: dizziness, ataxia, seizures, psychotic symptoms GI symptoms: nausea/vomiting
26
Therapeutic Use | Antifungal - amphotericin B
IV: severe systemic fungal infections that are likely to be fatal if not treated with amphotericin B Topical, oral suspension: candida infections of the skin and mucous membranes Urinary irrigation may be used to treat candida infections of the bladder or lower urinary tract
27
Adverse Effects | Bronchodilators - albuterol
Chest pain, palpitations | Nervousness, restlessness, tremors
28
Medication Administration | Bronchodilators - albuterol
Follow manufacturer's instructions for using delivery devices Use short-acting preparations for acute exacerbations Use long-acting preparations for long-term control Inhale beta2-adrenergic agonists before inhaling glucocorticoids Follow dosage limits and schedules Watch for signs and triggers of impending exacerbation of asthma Keep a log of the frequency and intensity of exacerbations Notify the provider of changes in patterns of exacerbations
29
Pharmacological Action | Anticholinergics - ipratropium
Inhibits interaction of acetylcholine at receptor sites on the bronchial smooth muscle, resulting in decreased cyclic guanosine monophosphate and bronchdilation
30
Therapeutic Use | Mast Cell Stabilizers - cromolyn
Long-term treatment of allergy-related asthma Prophylaxis for exercise-induced bronchospasm Prophylaxis for seasonal allergy symptoms Management of allergic rhinitis (intranasally)
31
Adverse Effects | First-generation Antihistamine - diphenhydramine
``` Drowsiness, dizziness Anticholinergic effects (dry mouth, constipation) ```
32
Contraindications | Sympathomimetics - phenylephrine
Chronic rhinitis, narrow angle glaucoma, uncontrolled heart disease, dysrhythmia, or hypertension
33
Adverse Effects | ACE Inhibitors - captopril
Severe hypotension following first dose (most likely in clients taking diuretics, with high BP, or who have hyponatremia) Dry, nonproductive cough due to increase in bradykinin Rash and report of metallic taste in mouth Angioedema (swelling of mouth, throat due to inhibition if kinase II) Hyperkalemia Neutropenia (decrease in white blood cells with increased risk of infection)
34
Contraindications | ACE Inhibitors - captopril
Teratogenic effects, angioedema or allergy to ACE inhibitors, hypotension, liver disease with elevated liver enzymes
35
What is the suffix for angiotensin II receptor blockers?
-sartan
36
Adverse Effects | Beta-Blockers - atenolol
Bradycardia due to blockade of beta1receptors; may lead to reduced cardiac output Heart failure (HF) - (SOB, edema, coughing at night) Rebound excitation causing angina pain or MI with sudden withdrawal of beta blocker in client with CHD
37
Medication Administration | Beta-Blockers - atenolol
Monitor heart rate, report rate slower than 60 BPM
38
Nursing Interventions | Direct Acting Vasodilator - hydralazine
Advise client that headache and tachycardia can occur Monitor pulse and report tachycardia A beta blocker can be added to decrease tachycardia watch for hypotension with additional antihypertensive agent Monitor for and report signs of facial rash, joint pain, or fatigue to provider (hydralazine will be discontinued) Monitor for edema, crackles in lungs Hydralazine can be combined with a diuretic to minimize this effect Taper hydralazine slowly when discontinued
39
Adverse Effects | Statins - atorvastatin
Myopathy (pain in muscles, which can progress to rhabdomyolysis [breakdown of muscle protein causing kidney damage]) Hepatotoxicity
40
Medication Administration | nitroglycerin
``` Oral extended-release capsules Sublingual tablet Translingual spray Topical ointment Transdermal patch Intravenous ```
41
Medication Administration | Cardiac Glycoside - digoxin
Available as oral tablets, capsules, and elixir, as well as for IV use Give oral form with or without food Tablets may be crushed and mixed with food if necessary IV form may be administered directly over at least 5 minutes; monitor site carefully for infiltration, which can cause tissue damage
42
Adverse Effects | Potassium Sparing Diuretic - spironolactone
Hyperkalemia Menstrual irregularities, abnormal hair growth (e.g. on face) and deepening of voice may occur in women Gynecomastia (growth of breast tissue) and impotence may occur in men
43
Adverse Effects | Loop Diuretic - furosemide
Electrolyte imbalance: hyponatremia, hypochloremia, severe fluid loss (dehydration), and hypokalemia Hypotension Ototoxicity (all loop diuretics can be temporary or permanent depending on the specific drug) Hyperglycemia (especially in clients who have diabetes mellitus) Increased uric acid levels (hyperuricemia) with possible gouty arthritis in susceptible clients
44
Therapeutic Use | Class III Potassium Channel Blocker - amiodarone
Manages life-threatening ventricular tachycardia or fibrillation that is resistant to other drugs May treat some dysrhythmias, such as atrial fibrillation
45
Contraindications | Estrogen
``` History of or risk for thromboembolic events Suspected or confirmed breast, vaginal, cervical, or endometrial cancer Liver disease Undiagnosed vaginal bleeding Hypertension Gallbladder disease Diabetes mellitus Heart disease Migraines Kidney dysfunction ```
46
Nursing Interventions | Uterine Stimulant - oxytocin
Monitor risk factors such as multiple deliveries Monitor length, strength, and duration of contractions For indications of hyperstimulation, turn clients on their side, stop the infusion, and administer oxygen Be prepared to administer a uterine relaxant Monitor for headache, nausea, vomiting, and increasing blood pressure Monitor intake and output and level of consciousness
47
Therapeutic Use | Alpha-Adrenergic Receptor Antagonist - tamsulosin
Treatment of benign prostatic hypertophy
48
Therapeutic Use | Antiemetic Drug - ferrous sulfate
Iron-deficiency anemia | Prevention of iron-deficiency anemia for clients at risk (infants, children, pregnancy, ongoing blood loss)
49
What lab is monitored with Heparin?
aPTT
50
What is the antidote for Heparin?
protamine
51
What lab is monitored for warfarin?
INR
52
What is the antidote for warfarin?
vitamin K
53
Adverse Effect | Thrombolytics - alteplase
Bleeding (intracranial, needle puncture sites, wounds)
54
Interactions | Biguanides - metformin
Alcohol and cimetidine increase the risk of lactic acidosis Any contrast medium containing iodine increases the risk of acute renal failure, thus worsening lactic acidosis. Drug should be stopped 24 hours before dye and 48 hours after test is completed Nifedipine, furosemide, morphine, ranitidine, antifungals, and many other drugs increase hypoglycemic effects
55
Medication Administration | Insulin
Give subcutaneously (using an insulin syringe with measurement in units) or IV (only Humulin R) Select an appropriate needle length for injecting insulin into subcutaneous tissue versus intradermal (too short) or intramuscular (too long). For insulin suspensions (cloudy insulins), gently rotate the vial between your palms to disperse the particles. When mixing short-acting insulin with longer (intermediate)-acting insulin, draw the short-acting insulin into the syringe first, then the longer-acting insulin. Do not mix insulin glargine or insulin detemir with any other insulin. Do not administer short-acting insulins if they appear cloudy or discolored. Instruct clients to self-administer insulin subcutaneously in one general area for consistent absorption rates. Storage of insulin. Keep vials in use at room temperature for 1 month. Refrigerate unopened vials of a single type of insulin until their expiration date. Keep insulins premixed in syringes for 1 to 2 weeks under refrigeration and vertical, with the needles pointing upward. Prior to administration, resuspend the insulin via gentle motion. Expect dosage adjustments in response to caloric intake, infections, exercise, stress, growth spurts, and pregnancy. Make sure adequate glucose available at onset and peak insulin times.
56
Therapeutic Use | Thyroid Replacement - levothyroxine
Hypothyroidism
57
Therapeutic Use | Proton Pump Inhibitor - omeprazole
``` Gastric and Duodenal Ulcers Prolonged dyspepsia Gastrointestinal reflux disease (GERD) Erosive esophagitis Hypersecretionary disorders such as Zollinger-Ellison syndrome, systemic mastocytosis ```
58
Pharmacological Action | Antacids - aluminum hydroxide
Antacids are alkaline compounds that neutralize gastric acid
59
Adverse Effects | Antacids - aluminum hydroxide
Constipation Diarrhea Hypophosphatemia
60
Medication Administration | Bulk-Forming Agents - psyllium
Give orally one to three times a day with at least 8 oz of fluid Mix powdered forms with 8 oz of fluid Expect soft, formed stools 1 to 3 days after initiating therapy Tell client that taking it before meals may reduce appetite
61
Adverse Effects | Antineoplastic - methotraxate
``` Bone marrow suppression (decreased platelets, red and white blood cells) Increased risk of infection Liver damage Gastrointestinal ulceration Pulmonary fibrosis Dizziness and headache Nausea and vomiting ```
62
Therapeutic Use | Bisphosphonate - alendronate
Prevention and treatment of: postmenopausal osteoporosis, glucocorticoid-related osteoporosis, age related osteoporosis in men
63
What are the signs and symptoms of hypoglycemia?
Confusion, shakiness, heart palpitations | Excessive hunger, pallor, sleepiness, slurred speech
64
What lab needs to be completed before antibiotics can be given?
Testing of body fluids: blood urine, sputum, wound drainage Gram stain: examine an aspirate of body fluids under a microscope to identify microorganisms directly Culture: aspirate is applied to a culture where colonies can grow
65
What is a normal Potassium level and how does potassium effects digoxin?
Normal potassium level is 3.6 to 5.2 mmol/L | Digoxin binds to potassium
66
What is the patient treatment for a heart attack?
Cath lab - opens arteries with stents MONA - Morphine, Oxygen, Nitroglycerin, Aspirin Fibrinolytic Therapy Beta-blocker post MI
67
What is the treatment for anaphylactic shock?
Administer antihistamine and provide for an open airway
68
What are the 10 rights of medication?
``` Right Drug Right Patient Right Dose Right Route Right Time Right Documentation Right History Right to Refuse Right Evaluation Right Education ```
69
What are signs of fluid volume overload?
Rapid weight gain Edema in peripheral extremities Shortness of breath, chest pain, heart failure High blood pressure
70
What are nursing interventions for IV infiltration?
Stop IV and start a new one somewhere else. Observe patient.
71
What is the procedure for administering high alert medications?
Have second nurse present.
72
When should an incident report be completed?
Immediately
73
Explain the medication reconciliation process
Checking physician orders. patient history, discharge orders
74
Identify ways to prevent medication errors
Prepare medication in private area 3 medication checks Have second nurse assist if unsure