Fifer Test 1

Answer 1

Adenine

Answer 2

Guanine

Answer 3

Cytosine

Answer 4

Uracil

Answer 5

Thymine

Question 6

Compounds in which the purine or pyrimidine base is covalently linked to carbon number 1 of a sugar?

Answer 6

Neucleosides

Question 7

In RNA the sugar is?

Answer 7

D-ribose=ribonucleoside

Question 8

In DNA the ribose is reduced at the number 2 carbon to afford?

Answer 8

deoxyribose=deoxyribonucleoside

Answer 9

adenosine

Answer 10

guanosine

Answer 11

2-deoxyadenosine

Answer 12

2’ deoxyguanosine

Answer 13

cytidine

Answer 14

uridine

Question 15

The phosphate ester of a nucleoside.

Answer 15

Nucleotide

Question 16

Function of nucletodies in the body (5)

Answer 16

1. carriers of activated groups in the synthesis of carbs, lipids, and proteins
2. structural components of coenzymes (FAD, NAD+, NADP+, coenzyme A
3. energy sources for cellular processes (ATP, GTP)
4. precursors for DNA and RNA synthesis
5. second messengers

Question 17

Methotrexate inhibits

Answer 17

dihydrofolate reductase

Question 18

What must happen to FH2 before it can accept a one carbon unit and act as a coenzyme?

Answer 18

Must be reduced to FH4

Question 19

How are Folic Acid and Folic Acid coenzymes transported into the cell?

Answer 19

Actively

Question 20

Once Folic Acid (FH) is inside they are polyglutamylated by an enzyme known as?

Answer 20

folypolyglutamyl synthetase

Question 21

Polyglutamylated folates:

Answer 21

• exhibit greater affinity for folate-dependent enzymes required for purine and thymidylate synthesis
• they do not have greater affinity for dihydrofolate reductase

Question 22

What makes up the majority of nucleotides found in cells?

Answer 22

5’ nucleotides