Fibromyalgia & Myofascial Pain Syndrome Flashcards

1
Q

nociceptive pain pathway

A

*communication from peripheral nerves → dorsal horn of spinal cord → brain → back to spinal cord
*communication between brain and spinal cord is via spinothalamic tract

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2
Q

nociceptive pain

A

*stimulation coming from the periphery; external stimulus
*includes somatic (bones, muscles) & visceral (organs) pain
*the stimulus-response process involving stimulation of peripheral pain-carrying nerve fibers and the transmission of impulses along peripheral nerves to the CNS, where the stimulus is perceived as pain

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3
Q

neuropathic pain

A

*pain that is caused by a pathology within the nervous system and is typically described as burning, stabbing, shooting, numbness, or tingling
*can be central or peripheral

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4
Q

nociplastic pain

A

*altered recognition and/or transmission of pain: hypersensitization / hyperresponsiveness
*pain that arises or is sustained by altered nociception, despite the absence of tissue damage
*fibromyalgia and other chronic pain conditions fall in this category

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5
Q

myofascial pain syndromes (MPS) - defined

A

*MPS: sensory, motor, and autonomic symptoms caused by myofascial trigger points
*trigger points: a hyperirritable focus within a taut band of skeletal muscle or fascia
-painful on compression
-produce a local twitch response on muscle manipulation (snapping)

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6
Q

myofascial pain syndromes (MPS) - clinical features

A

*predisposition to muscle microtrauma (deconditioned state, poor posture, underlying arthritis, certain occupations or recreational activities)
*persistent pain at REST
*restricted movement
*referred pain (does not follow dermatome or nerve distribution)

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7
Q

ddx for myofascial pain syndromes (MPS)

A

*regional: bursitis, tendinitis, axial radiculopathy
*diffuse: fibromyalgia
*overlapping syndrome: significant overlap between MPS and fibromyalgia; trigger point areas may entrap a nerve

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8
Q

myofascial pain syndromes (MPS) - treatment

A

*physical therapy
*identify predisposing MSK abnormalities
*correct posture and/or other abnormal mechanics
*transcutaneous electrical stimulation
*thermal modalities
*trigger point injection

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9
Q

fibromyalgia (FM) - overview

A

*most common rheumatic cause of widespread pain
*clinical features: diffuse aching and stiffness, fatigue, sleep disturbances
*diagnosis based on 2 parameters:
-widespread pain index
-symptom severity scale

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10
Q

fibromyalgia (FM) - clinical features

A
  1. diffuse aching and stiffness
  2. fatigue
  3. sleep disturbance
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11
Q

fibromyalgia diagnostic criteria

A

*the following 3 conditions should be present:
1) widespread pain index 7+ and symptom severity score 5+ OR WPI 3-6 and SS score 9+
2) symptoms have been present at a similar level for 3+ months
3) patient does not have a disorder that would otherwise explain the pain

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12
Q

ddx for fibromyalgia

A

other diffuse pain syndromes:
*systemic rheumatic disease
*infections (ex. Hep C)
*chronic fatigue
*hyper- or hypothyroidism
*fibromyalgia

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13
Q

fibromyalgia (FM) - central sensitization

A

*central sensitization: abnormalities of descending inhibitory pain pathways
*allodynia: sensations that were formerly non-painful now become painful
*hyperalgesia: sensations that formerly were mildly painful now become excessively painful
*temporal summation: after an initial painful stimulus, subsequent equal stimuli are perceived to be more intensely painful

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14
Q

fibromyalgia (FM) - pathophysiology

A
  1. central sensitization
  2. neurotransmitter abnormalities
  3. neurohormonal abnormalities
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15
Q

roles of stress/psychological factors in fibromyalgia (FM)

A
  1. predisposing factors (physical abuse, trauma, injuries)
  2. triggering factors (life threatening events)
  3. PERPETUATING FACTORS:
    -the alarming portrayal of the condition as catastrophic and disabling
    -pain signifies damage and that activity should be avoided
    -one is unable to function because of pain
    -higher body-related attention
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16
Q

fibromyalgia (FM) - epidemiology

A

*women > men (60-70% female)
*peak age: 30-50
*can have its onset in childhood; can present over age 60

17
Q

fibromyalgia (FM) - associated symptoms

A

*fatigue
*sleep disturbances
*stiffness
*paresthesias
*headaches
*IBS (irritable bowel syndrome)
*depression
*anxiety

18
Q

secondary fibromyalgia (FM)

A

*can occur in the following settings:
-rheumatoid arthritis, lupus, scleroderma, other connective tissue diseases
-Hep C, HIV
-multiple sclerosis

19
Q

fibromyalgia (FM) and depression

A

*increased rates of depression in pts with fibromyalgia
*the presence of depression worsens pain outcomes and vice versa
*despite substantial overlap, most pts with FM are NOT clinically depressed

20
Q

lab tests to exclude medical conditions that may be presenting as fibromyalgia

A

*thyroid test (rule out hypo or hyperthyroidism)
*glucose
*creatinine and SGPT
*blood count

21
Q

fibromyalgia (FM) - general treatment principles

A

*education - nature of the illness
*improve quality of sleep
*increase level of physical activity (graded aerobic exercise)
*consider pharmacological treatment for pain relief or relief of coexisting psych disorders (non-drug approach is preferred)

22
Q

fibromyalgia (FM) cognitive behavioral therapy

A

includes:
*progressive muscle relaxation
*activity pacing
*pleasant activity scheduling
*reframing of negative or self-defeating thoughts
*problem solving skills and stress management

23
Q

drugs used in fibromyalgia (FM)

A
  1. tricyclic compounds
  2. muscle relaxants
  3. serotonin norepinephrine reuptake inhibitor (SNRI) [ex. duloxetine]
  4. anti-convulsants [ex. pregabalin]
24
Q

myofascial pain syndrome (MPS) vs fibromyalgia (FM)

A

*MPS is more of peripheral nociception (nociceptive pain)
*FM is more of central nociception (nociplastic pain)