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Paramedic Drugs > Fibrinolytics > Flashcards

Fibrinolytics Flashcards

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1
Q

Clopidogrel MOA

A

Anti-platelet that antagonizes adenosine diphosphate (ADP) binding to platelets, impairing function

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2
Q

Clopidogrel Preparation

A

75mg tablets

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3
Q

Clopidogrel Indication

A

STEMI in conjunction with fibrinolytic therapy

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4
Q

Clopidogrel Contraindications

A

Nil

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5
Q

Clopidogrel Precautions

A

Clinically significant bleeding
At risk of bleeding
Pregnancy

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6
Q

Clopidogrel Doses

A

<75yo 300mg (x4 tablets)

>75yo 75mg (x1 tablet)

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7
Q

Clopidogrel Onset

A

30-60min

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8
Q

Clopidogrel Duration

A

The life of the platelet, 3-5 days

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9
Q

Clopidogrel Adverse Effects

A

Increased bleeding

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10
Q

Enoxaparin MOA

A

Low molecular weight Heparin (LMWH) anticoagulant that potentiates the activity of anti-thrombin III, inhibiting multiple coagulation factors- particularly Xa

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11
Q

Enoxaparin Preparation

A

100mg 1ml

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12
Q

Enoxaparin Indication

A

STEMI in conjunction with fibrinolytic therapy

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13
Q

Enoxaparin Contraindication

A

Nil

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14
Q

Enoxaparin Precautions

A

Clinically significant bleeding
At risk of bleeding
Pregnancy

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15
Q

Enoxaparin Doses

A

Based off age & weight- see chart

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16
Q

Enoxaparin Onset

A

10-30min

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17
Q

Enoxaparin Duration

A

12-24hrs

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18
Q

Enoxaparin Adverse Effect

A

Increased bleeding

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19
Q

Heparin MOA

A

Anticoagulant that potentiates activity of anti-thrombin III, inhibiting multiple coagulation factors

20
Q

Heparin Preparation

A

5000 units 0.2ml

21
Q

Heparin Indication

A

STEMI in conjunction with fibrinolytic therapy

22
Q

Heparin Contraindication

A

> 75yo

23
Q

Heparin Precaution

A

Clinically significant bleeding
At risk of bleeding
Pregnancy

24
Q

Heparin Dose

A

5000 units diluted to a total of 5-10mls IV bolus

25
Q

Heparin Onset

A

5-15min

26
Q

Heparin Duration

A

2-4hrs

27
Q

Heparin Adverse Effect

A

Increased bleeding

28
Q

Metoprolol MOA

A

Beta blocker that antagonizes beta1 receptors, decreasing HR, CO, and BP

29
Q

Metoprolol Preparation

A

5mg 5ml

30
Q

Metoprolol Indication

A

HTN prior to STEMI fibrinolytics

31
Q

Metoprolol Contraindications

A

Bradycardia

Hypotension

32
Q

Metoprolol Precautions

A

1st degree heart block
Sick sinus syndrome without pacemaker
2nd or 3rd degree heart block without pacemaker
Asthma/COPD/HF

33
Q

Metoprolol Dose

A

2.5mg IV

34
Q

Metoprolol Onset

A

2-3min

35
Q

Metoprolol Duration

A

1-2hrs

36
Q

Metoprolol Adverse Effects

A

Bradycardia
Bronchospasm
Hypotension

37
Q

Tenecteplase MOA

A

Fibrinolytic that accelerates the breakdown of blood clots and converts plasminogen into plasmin (active enzyme) that breaks down fibrin in clots

38
Q

Tenecteplase Dose

A

Based off age + weight, see chart

39
Q

Tenecteplase Onset

A

5-10min

40
Q

Tenecteplase Duration

A

2-6hrs

41
Q

Tenecteplase Preparation

A

50mg powder

42
Q

Tenecteplase Indication

A

STEMI in conjunction with fibrinolytic therapy

43
Q

Tenecteplase Contraindications

A 
Suspected aortic dissection
Major surgery/trauma/TBI 6/52
Intracranial surgery within 6/12
Ischaemic CVA within 6/12
Previous Intracerebral Bleed
Known cerebral aneurysm/malformation/tumor
44
Q

Tenecteplase Precautions

A 
Clinically significant bleeding
>10min CPR
Vascular puncture within 24hrs
Internal bleed within 6/52
Lumbar puncture within 6/52
TIA within 3/12
Known bleeding disorder
Anticoagulant
SBP >180 or DBP >110
Pregnant or <2/52 post partum
Onset of sxs >12hrs
Dependant activities daily living
Comorbidity shortening life
Frail
45
Q

Tenecteplase Adverse Effects

A

Increased bleeding

Dysrhythmia

Paramedic Drugs (2 decks)

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