Fibrinoid degeneration (dystrophy)

Question 1

What type of dystrophy is fibrinoid degeneration?

Answer 1

Extracellular/mesenchymal dysproteinemia

Question 2

What causes fibrinoid degeneration?

Answer 2

Long-lasting hypoxia, toxication, metabolic conditions, hypovitaminosis (C,E,K), allergic diseases, endocrine dysfunctions

chronic inflammation –> localised fibrinoid degeneration

Question 3

What is fibrinoid and how does it form?

Answer 3

Connective tissue integrates + collagen fibres swell and break down
–> These fibres + ground substance soak into plasma fibrin and form fibrinoid

Question 4

Can you see external signs of fibrinoid degeneration?

Answer 4

Not visible externally, only microscopically

Question 5

How does fibrinoid degeneration affect the organ?

Answer 5

Causes functional problems, fibrinoid can later be replaced by connective tissue or hyalin (hyalinosis). Can also lead to fibrinoid necrosis.