FETUS Flashcards
Difference between gestational age and period after fertilisation
TROPHOBLAST DIVIDES INTO CYTO ROPHOBLAST AND syncitiotrophoblast 8days after fertilisation what is the gestational age of the fetus
Gestational age or fetal age or period of pregnancy are taken from 1st day of last menstrual period & period after fertilisation is from 14th day of the cycle when fertilisation occurs
Gestational age =2 weeks + period after fertilisation
Ans for above
2weeks + 8days
Everything by default is taken to be gestational age xcept
Fetal growth periods
These are normally xpressed indays after fertilisation
Different growth period of a baby
Fertilised ova ( zygote) From day of fertilisation:-2weeks Gestational age 4 weeks Embryo 3to8weeks 5 to 10 weeks Fetal Morethan or = 9 weeks 11 weeks
Most teratogenic period
Embryonivc period
Total duration of pregnancy and division into trimester
Total duration = 280days/40weeks/9month \+ 7 days Trimester accto williams 1st= 13weeks+ 6days 2nd = 14weeks till 27weeks + 6days 3rd = 28weeks till 40 weeks
Estimation of fetal age clinically ?
By fundal heigt
See image in marrow notes
What is lightening or welcome sign
Marrow notes
Usg estimation of fetal age what parameters are used?
Marrow notes
When is usg more accurate
Early in pregnancy
Edd should not be changed based on usgxcept in
Cases of ivf
Crown rump length is a measurement taken fromwhat to what
GESTATIONAL AGEIN WEEKS?
GEST AGE IN DAYS =?
BASED ON CRL
Marrow notes
Crown rump length increases at rate of
1 mm per day
Smallest CRL at which embryo is visible
4 to 5 mm
If CRL IS MORE THAN or =7 MM WITH NO CARDIAC ACTIVITY
Missed abortion
Suboptimally dated on usg
If a female has not got any usg done before 22 weeks of pregnancy
Biparietal diameter measured frm?
Outer table of one side to inner table of another side
Hasse rule?
Marrow notes
Assesment of weight of fetus
Clinically jhonsons formula
Usg= shepherd formula
Hadlock formula
Assesment of fetal growth on usg is done by?
Abdominal circumference it should be measured in a plane where portAl sinus umblical vein & stomach are visible
Macrosomia called when?
Abdominal circumferance=or more than 35cm
Femoral length divided by abdominal circumfernce is equal to
Normal
Ratio increased in?
Decresd in?
20 to 40 %
Inc = IUGR
DEC = SKELETAL DYSPLASIA
Fetal hematopoesis occurs at what site and type of hb produced
Marrow notes
Initially fetal rbcs are nucleated and macrocytic later size decreases but this does not happen in
Aneuploid fetuses
Diff btw detal & adult rbcs
Fetal rbcs are macrocytic and short life span ( 90) days
At the time of birth amnt and comp of hb of baby
16 to 18 g/ dl
75 to 80% hbf
20 to 25 % hba
By what age hbf will be less than 1 %
6 months
Hbf and hba diff
Marrow notes
Fetal gross movements seen at
7 weeks
Meconium production starts at
16 weeks or 4 months
Gonad formation which one formed first
7 weeks
Testis formed first
Internal genitilia formed by
10 weeks
External genitilia
100 % sex can be determined by.
Female 12 weeks
Male 14 weeks
14 weeks
Glucagon synthesis by
8 weeks
Breathing movements
11 weeks
Insulin production & hp axis
12 weeks
Featl urine
12 weeks
Igm production begins at
IGg transported to fetus at
20 weeks
16 weeks
Surfactant production begins at?
Present in amniotic fluid by
20weeks
28weeks
Uses of usg in pregnancy
To confirm preg Intrauerine preg / ectopic preg To know twin preg To detect congenital malformations To asses growth of fetus and fetal age
High freq usg bettr?
Low freq usg bettr?
Resolution
Penetration
Advisable usg freq?
Early preg- 5 to 10 megahz
Late qst & 2nd trim 4 to 6 MHZ
3 RD TRIM 2 TO 5MHZ
Alara principle?
Xpose preg female to usg as low as reasonably advised
Routine usg _ mode?
BMODE
To see cardiac activity what mode.
M MODE
At what period following structures are seeen inTAS /TVS
GEST SAC
YOLK SAC
CARDIAC ACTIVITY
Marrow notes
1st sign of preg on usg
Gest sac
1st sign of intrauterine preg
Yolk sac
Diff btween intrauterine preg and ectopic preg
Marrow notes
What is blighted ovum
Mean sac diametr > or= 25mm & no fetal tissue/ yolk sac / cardiac activity
Types of usg in preg and what can they dtect
Marrow notes
Best time to do Tiffa
16 to 20 weeks
Annenceephaly on usg
Earliest time to be detected?
Best time to bedetected
Signs
Marrow notes
Signs of spina bifida on usg
Marrow notes
Best time for usg to localise placenta
3rd trim
Most common presentation in anencephaly
Face
Anencephaly presents with?
Vault or skull absent
Hypoplastic adrenals- post dated preg
Polyhydramnios
Which defect more common in females & which one in males.
Anencephaly - F
Respiratory distress & macrosomia - M
Managment of anencephaly
MTP
Folic acid supplementation benefits?
Marrow
Dosage of folic acid?
Marrow notes
Ideal time for giving folic acid
MN
Tab provided by govt of india contains
RDA for FA in pregnant female
500mcg
500mcg
Folic acid dosage in females with histry of NTD
MN
Diag of anencephaly Screening test? Routinely done Best done ? Diagnostic test earlier? & now.
Mn
Alpha feto protien ( AFP)
SYNTH BY?
Major source?
Mn
At what times it is present in fetal serum? Amniotic fluid?
Maternal serum?
Highest at13 weeks
Highest at 13 weeks
Highest at 32 weeks
T half of afp
5 to 7 days
Increases afp seen in.?
Dec afp seen in?
Mn
Earlistime at which gestational sac can be identified on tvs fromLMP A) 20 day B)25day C)30days D)35days
Ans C
Earliest time gestational sac can be identified on tvs from fertilisation A) 20days B)25days C)30days D)35days
A
Gestational sac can be visualised on usg A)4weeks B)5weeks C)6weeks D)7weeks
B
Female 6 weeks preg came with spottingin usg mean sac diametr 20mm
What is nxt step?
I will wait for 1 week and then take mean sac diameter and if it is more than 25mm and still no fetal tissue appears then ieill call it blighted ovum
what is another name of apt test?
singer alkali denaturation test
difference between apt test and kleuhar betke test under following headings? purpose? reagent? type qualt or quant? differentiates btw?
mn
signs of anencephaly on usg?
frog eye sign
mickey mouse sign
signs of spina bifida can be detected in which trimester?
1st
is ventral wall defect normal in a fetus?
when is it pathological?
yes it is physiological upto 12 weeeks
it is pathological when it continuies beyond 12 weeks
or size of defect is more than or equal to 7mm
what is the pathological ventral wall defect called?
how do u diff between two?
gastroschesis
omphalocele
omphalocele is covered by sac defect will have smooth contour on usg in gastroschisis defect will have irregular contour
most sensitive biochemical marker for anencephaly or neural tube defct
acetylcholineesterase
when is the screening test of maternal srum afp positive in single preg? in twin preg?
> or equal to 2.5 multiples of meridian insingle preg
>or equal to 3.5 multiples of meridian in twin preg