Fertilisation to Trilaminar Disc Flashcards
What is meant by a zygote, and when is it formed?
Fertilised oocyte
12 hours following ovulation
Occurs in the ampulla of the Fallopian tube
What is meant by cleavage?
First mitotic division
Occurs 30 hours following fertilisation
Cellular division to form the blastomere
What is meant by morula?
Blastocyst undergoes further mitotic divisions to form a 16 cell structure contained within the zona pellucida
What is meant by a blastocyst?
Cells of the morula organise in to inner cell mass and outer cell mass
What are the key steps of differentiation?
Inner cell mass - epiblast and hypoblast
Cavity within the epiblast is amniotic cavity
Outer cell mass differentiates to become cytotrophoblast and syncytiotrophoblast
Hypoblast forms Heusers membrane which lines the yolk sac
What is meant by gastrulation?
Primitive streak appears on epiblast
Epiblast cells proliferate and invaginate through the epiblast
Hypoblast displaced and undergoes apoptosis
Migrating epiblast cells spread out to form two additional layers
This forms the trilaminar disc
What are the three parts of the organised mesoderm?
Para-axial
Lateral (somatic and splanchnic)
Intermediate
Which structures are derived from the ectoderm?
Epidermis
Brain and spinal cord
Peripheral nerves
Retina and iris
Which structures are derived from the mesoderm?
Bone, muscle and cartilage
Blood vessels
Dermis
Urogenital system
Which structures are derived from the endoderm?
GI tract
Lungs
From day 1 to 5 following fertilisation, how many cells does the zygote consist of?
Day 1 = 2 cell BLASTOMERE Day 2 = 4 cells Day 3 = 8 cells Day 4 = 16 cells MORULA Day 5 = 100+ cells BLASTOCYST
How many days following fertilisation does hatching occur?
Day 6
What type of cells are the syncytiotrophoblast?
Multi-nucleated
What type of cells are the cytotrophoblast?
Mononucleated
When does the buccopharyngeal membrane break down?
4th week