Fertilisation to Trilaminar Disc Flashcards

1
Q

What is meant by a zygote, and when is it formed?

A

Fertilised oocyte
12 hours following ovulation
Occurs in the ampulla of the Fallopian tube

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2
Q

What is meant by cleavage?

A

First mitotic division
Occurs 30 hours following fertilisation
Cellular division to form the blastomere

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3
Q

What is meant by morula?

A

Blastocyst undergoes further mitotic divisions to form a 16 cell structure contained within the zona pellucida

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4
Q

What is meant by a blastocyst?

A

Cells of the morula organise in to inner cell mass and outer cell mass

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5
Q

What are the key steps of differentiation?

A

Inner cell mass - epiblast and hypoblast
Cavity within the epiblast is amniotic cavity
Outer cell mass differentiates to become cytotrophoblast and syncytiotrophoblast
Hypoblast forms Heusers membrane which lines the yolk sac

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6
Q

What is meant by gastrulation?

A

Primitive streak appears on epiblast
Epiblast cells proliferate and invaginate through the epiblast
Hypoblast displaced and undergoes apoptosis
Migrating epiblast cells spread out to form two additional layers
This forms the trilaminar disc

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7
Q

What are the three parts of the organised mesoderm?

A

Para-axial
Lateral (somatic and splanchnic)
Intermediate

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8
Q

Which structures are derived from the ectoderm?

A

Epidermis
Brain and spinal cord
Peripheral nerves
Retina and iris

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9
Q

Which structures are derived from the mesoderm?

A

Bone, muscle and cartilage
Blood vessels
Dermis
Urogenital system

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10
Q

Which structures are derived from the endoderm?

A

GI tract

Lungs

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11
Q

From day 1 to 5 following fertilisation, how many cells does the zygote consist of?

A
Day 1 = 2 cell BLASTOMERE
Day 2 = 4 cells
Day 3 = 8 cells
Day 4 = 16 cells MORULA
Day 5 = 100+ cells BLASTOCYST
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12
Q

How many days following fertilisation does hatching occur?

A

Day 6

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13
Q

What type of cells are the syncytiotrophoblast?

A

Multi-nucleated

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14
Q

What type of cells are the cytotrophoblast?

A

Mononucleated

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15
Q

When does the buccopharyngeal membrane break down?

A

4th week

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16
Q

When does the cloacal membrane break down?

A

7th week

17
Q

When does embryo folding occur?

A

Day 21-24

18
Q

Name three neural crest derivatives

A

Sympathetic chain
Adrenal Medulla
Melanocytes

19
Q

What are the layers of sperm penetration in to the secondary oocyte at fertilisation?

A

Corona radiata
Zona Pellucida
Perivitelline Space
Plasma membrane

20
Q

When does the first pair of somites appear?

A

Day 20

21
Q

When do primordial germ cells originate?

A

Originate from the epiblast
Move to the yolk sac
Then move to occupy the primitive gonads