Female Repro

Question 1

Bartholin usually occurs in this age group:

Answer 1

Women of reproductive age

Question 2

Cause of condyloma

Answer 2

Condyloma acuminatum: HPV 6, 11

Condyloma latum: secondary syphilis

Question 3

Hallmark of condyloma

Answer 3

Koilocytes

Question 4

Lichen sclerosis is characterized by?

Answer 4

Thinning of epidermis, sclerosis or fibrosis of dermis

Question 5

How does lichen sclerosis present?

Answer 5

Leukoplakia, parchment-like vulvar skin

Question 6

Lichen sclerosis has increased risk for?

Answer 6

Squamous cell carcinoma

Question 7

Lichen simplex chronicus is characterized by?

Answer 7

Hyperplasia of vulvar squamous epithelium

Question 8

Lichen simplex chronicus presents as?

Answer 8

Leukoplakia, thick leathery vulvar skin

Question 9

This is associated with chronic irritation and scratching

Answer 9

Lichen simplex chronicus

Question 10

HPV types related to vulvar carrcinoma

Answer 10

HPV 16, 18

Question 11

Age group for vulvar ca

Answer 11

Elderly, greater that 70 yo

Question 12

Extramammary paget disease is characterized by

Answer 12

Malignant epithelial cells in epidermis of vulva

Question 13

Differentiate the underlying carcinoma for extramammary paget disease and paget disease of the nipple

Answer 13

Extramammary paget disease has no underlying carcinoma.

Paget disease of the nipple is always associated with underlying carcinoma.

Question 14

Extramammary paget disease must be differentiated from?

Answer 14

Melanoma

Question 15

How do you differentiate extramammary paget diseases and melanoma?

Answer 15

Paget cells are PAS+, keratin+, S100-.

Melanoma is PAS-, keratin-, S100+.

Question 16

How does bartholin cyst present?

Answer 16

Unilateral, painful cystic lesion at the lower vestibule adjacent to the vaginal canal

Question 17

Pathology of adenosis of the vulva

Answer 17

Persistence of the columnar epithelium in the upper 1/3 of vagina instead of being replaced by squamous epithelium from lower 2/3 of vagina (derived from urogenital ridge)

Question 18

Risk factor for adenosis

Answer 18

Exposure to diethylstilbesterol (DES) in utero

Question 19

Px with adenosis have increased risk for?

Answer 19

Clear cell adenocarcinoma

Question 20

Clear cell adenocarcinoma pathology

Answer 20

Proliferation of glands with clear cytoplasm

Question 21

Px is less than 5 yo presenting with bleeding and grape like mass in vagina or penis. Dx?

Answer 21

Embryonal rhabdomyosarcoma or sarcoma botryoides

Question 22

Pathology of embryonal rhabdomyosarcoma

Answer 22

Proliferation of immature skeletal muscle

Question 23

Characteristic cell of embryonal rhabdomyosarcoma?

Answer 23

Rhabdomyomast- has cytoplasmic cross striations and positive for desmin and myogenin

Question 24

What is asherman syndrome?

Answer 24

Secondary amenorrhea due to loss of basalis and scarring

Question 25

What is the most common cause of asherman syndrome?

Answer 25

Overaggressive D&C

Question 26

Side effect of tamoxifen that presents as abnormal uterine bleeding?

Answer 26

Endometrial polyp

Question 27

Leiomyosarcoma arises from?

Answer 27

It arises de novo

Question 28

Leiomyosarcoma is usually seen in what age group

Answer 28

Postmenopausal women

Question 29

PCOS is characterized by?

Answer 29

Increased LH and low FSH (LH:FSH >2)

Question 30

How does estrone feedback work in PCOS?

Answer 30

Estrone feedback decreases FSH resulting in cystic degeneration of follicles. This leads to anovulation.

Question 31

PCOS increases risk for?

Answer 31

Endometrial cancer due to increased circulating estrone

Question 32

This may develop in px with PCOS due to insulin resistance

Answer 32

Type II DM

Question 33

How are ovarian tumors classified?

Answer 33

According to cell types in the compartment

Question 34

Three cell types of ovary where ovarian tumors arise

Answer 34

Surface epithelial Germ cell Sex cord

Question 35

Classification of surface epithelial tumors

Answer 35

1. Cystadenoma 2. Cystadenocarcinoma 3. Endometrial 4. Brenner

Question 36

Subtypes of surface epithelial tumor

Answer 36

Serous | Mucinous

Question 37

This mutation increases risk for serous carcinoma of fallopian tube and ovary

Answer 37

BRCA1 mutation

Question 38

% of endometrioid cardinoma of ovary that is associated with independent endometrial carcinoma

Answer 38

15%

Question 39

Brenner tumor

Answer 39

Bladder-like tumor and Benign

Question 40

Serum marker for surface epithelial tumor

Answer 40

CA-125