Female Genital Tract

Question 1

What body parts are commonly affected by genital herpes simplex virus (HSV) infection?

Answer 1

vulva, vagina, or cervix

Question 2

what are the two serotypes of HSV viruses?

Answer 2

HSV-1 and HSV-2

Question 3

HSV-1 typically results in?

Answer 3

perioral infection

Question 4

HSV-2 typically involves?

Answer 4

genital mucosa and skin

Question 5

By 40 years of age, what percentage of females are seropositive for antibodies against HSV-2?

Answer 5

30%

Question 6

Genital herpes typically develops within?

Answer 6

3-7 days after transmission

Question 7

What are the systemic symptoms associated with genital herpes?

Answer 7

fever, malaise, and tender inguinal lymph nodes

Question 8

genital herpes: lesions typically consist of?

Answer 8

red papules that progress to vesicles and then to painful coalescent ulcers

Question 9

genital herpes: lesions are easily visible on?

Answer 9

vulvar skin and mucosa

Question 10

genital herpes: cervical and vaginal lesions are present with?

Answer 10

purulent discharge and pelvic pain

Question 11

What antiviral agents are used to shorten the length of the initial and recurrent symptomatic phases of genital HSV infection?

Answer 11

acyclovir or famciclovir

Question 12

Diagnosis of cervical intraepithelial neoplasia is based on?

Answer 12

identification of nuclear atypia

Question 13

nuclear atypia is characterized by (CHEV)?

Answer 13

coarse creatine granules, hyperchromasia (darkening of nucleus), enlarged nucleus, hyperchromasia (darkening of nucleus), and variation in nuclear size and shape

Question 14

two-tier CIN classification: CIN I

Answer 14

mild dysplasia

Question 15

two-tier CIN classification: CIN II

Answer 15

moderate dysplasia

Question 16

two-tier CIN classification: CIN III

Answer 16

severe dysplasia

Question 17

Three-tier CIN classification: CIN I

Answer 17

low-grade squamous intraepithelial lesion (LSIL)

Question 18

Three-tier classification of CIN: CIN II and III

Answer 18

high-grade squamous intraepithelial lesion (HSIL)

Question 19

nuclear alterations associated with perinuclear halos are termed?

Answer 19

koilocytic atypia

Question 20

If immature squamous cells are confined to the lower 1/3 of the epithelium, the lesion is called?

Answer 20

LSIL

Question 21

If immature squamous cells expand to the upper 2/3 of the epithelium, the lesion is called?

Answer 21

HSIL

Question 22

The highest viral loads of HPV in LSIL are found in?

Answer 22

maturing keratinocytes in the upper half of the epithelium

Question 23

What is the most common type of of HPV in LSIL and HSIL?

Answer 23

Human papillomavirus-16

Question 24

More than _% of LSILs and _% of HSILs are associated with high-risk HPVs.

Answer 24

80; 100

Question 25

HSIL is considered to be at high risk for progression to?

Answer 25

carcinoma

Question 26

Percentage of LSIL that regress

Answer 26

60%

Question 27

Percentage of LSIL that persists

Answer 27

30%

Question 28

Percentage of LSIL that progress to HSIL

Answer 28

10%

Question 29

Percentage of HSIL that regress

Answer 29

30%

Question 30

Percentage of HSIl that persists

Answer 30

60%

Question 31

Percentage of HSIL that progress to carcinoma

Answer 31

10%

Question 32

Progression rate of HSIL to carcinoma is?

Answer 32

2 to 10 years

Question 33

The ability of HPV to act as a carcinogen depends on what viral proteins?

Answer 33

E6 and E7 proteins

Question 34

What do the viral proteins E6 and E7 do?

Answer 34

They interfere with the acitivty of the key tumor supressor proteins, p53 and RB

Question 35

Color of stain for cyclin-dependent kinase inhibitor p16 which characterizes high-risk HPV infections?

Answer 35

brown staining

Question 36

What is the fourth most common cancer in women?

Answer 36

cervical carcinoma

Question 37

How many high-risk HPVs are identified in cervical carcinoma?

Answer 37

15