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1. Pathology > Female > Flashcards

Female Flashcards

1
Q

Unilateral, painful cystic lesion at the lower vestibule adjacent to the vaginal canal / women of reproductive age

A

Bartholin cyst

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2
Q

Vaginal wart with Koilocytes

A

Condyloma

HPV 6 / HPV 11 / Secondary syphilis

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3
Q 
white patch (leukoplakia) with parchment-like vulvar skin "Paper-thin"
Postmenopausal women
A

Lichen sclerosis

benign, but slight risk for squamous cell carcinoma

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4
Q

Leukoplakia with a thick, leathery vulvar skin, chronic irritation and scratching

A

Lichen simplex chronicus

no risk of squamous cell carcinoma

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5
Q

Erythematous, pruritic, ulcerated vulvar skin, crusty area

A

Extramammary Paget disease

PAS + / keratin + / S100 -

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6
Q

Persistent columnar epithelium in the upper vagina

A

Adenosis

Increased incidence in females who were exposed to diethylstilbestrol (DES) in utero

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7
Q

Glands with clear cytoplasm

A

Clear Cell Adenocarcinoma

Feared complication of DES-associated vaginal adenosis

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8
Q

Bleeding and grape-like mass protruding in vagina or penis of child <5yo

Cytoplasmic cross striations

Positive desmin
Positive myogenin

A

Embryonal Rhabdomyosarcoma (Sarcoma botryoides)

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9
Q

High-risk HPV produces?

A

E6 - destruction of p53
E7 - destruction of Rb

Loss of tumor suppressor proteins increase risk for CIN

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10
Q

s/p D&C, has not menstruated since

A

Asherman syndrome 2/2 loss of basalis and scarring

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11
Q

Anovulatory cycle

A

estrogen-drive proliferative phase without a subsequent progesterone-driven secretory phase

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12
Q

Fever, AUB, pelvic pain

A

Acute Endometritis

retained products of conception

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13
Q

AUB, pain, infertility

Lymphocytes and plasma cells

A

Chronic Endometritis

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14
Q

AUB, tamoxifen use

A

Endometrial polyp

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15
Q

dysmenorrhea, pelvic pain, infertility

A

Endometriosis

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16
Q

Postmenopausal uterine bleeding

History of unopposed estrogen (obesity / PCOS / estrogen therapy)

A

Endometrial Hyperplasia

17
Q

Psammoma bodies

A

Endometrial Carcinoma
Papillary carcinoma (thyroid)
Meningioma
Mesothelioma

18
Q

AUB, infertility, Pelvic mass

A

Leiomyoma (fibroids)

19
Q

Obese young woman, infertility, oligomenorrhea, hirsutism

A

PCOS

20
Q

PCOS labs

A
  • LH:FSH >2
  • increased androgen (hirsutism)
  • androgen convert to estrone in adipose tissue
  • estrone feedback decreases FSH resulting in cystic degeneration of follicles
21
Q

Ovarian surface epithelial tumors

A

BRAC1 /BRAC2
poor prognosis
Monitor CA-125

22
Q

Germ cell tumors

A 
Teratoma
Dysgerminoma
Endodermal sinus tumor
Choricarcinoma
Embryonal carcinoma
23
Q

skin, hair, bone, cartilage, gut, thyroid in a section of ovary

A

Teratoma

STRUMA OVARII is teratoma composed of thyroid tissue (hyperthyroidism)

24
Q

Large cells with clear cytoplasm and central nuclei

serum LDH elevated

adnexal mass

A

Dysgerminoma

25
Q

Elevated AFP

Schiller-Duval bodies (glomerulus-like structures)

A

Endodermal sinus tumor / Yolk Sac tumor

26
Q

Composed of cytotrophoblasts & syncyntiotrophoblasts
Mimics placental tissue but lacks villi

High beta-hCG

A

Choriocarcinoma

27
Q

Large primitive cells
Average age of 15yo
Hemorrhage and necrosis
Aggressive early metastasis

A

Embryonal carcinoma

28
Q

Signs of estrogen excess
Prior to puberty - precocious
Reproductive age - menorrhagia & metrorrhagia
Postmenopause - endometrial hyperplasia & AUB

A

Granulosa-theca cell tumor

29
Q

Pink cells with crystals (Reinke crystals)

Hirsutism & virilization

A

Sertoli-Leydig cell tumor

30
Q

Pleura effusions and Ascites (Meigs syndrome)

A

Fibroma

31
Q

h/o gastric carcinoma
Signet ring cells in ovaries
bilateral involvement

A

Krukenberg tumor

32
Q

Massive amounts of mucus in the peritoneum

Due to mucinous tumor of appendix

A

Pseudomyxoma peritonei

1. Pathology (1 decks)

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