FDN2 Drugs Week 1 Flashcards
To learn the name of drugs so I can do well on Step so I can match into a cool field so I can seem like an accomplished person.
What does Diazepam do?
It is a benzodiazepine and thus acts as an Allosteric activator of GABAA receptors
This benzo binding increases the frequency of opening of GABAA-gated Cl- channels and enhances synaptic inhibition. The TI for diazepam is very good (~100)
Used to treat anxiety, to produce sleep and reduce muscle spasms.
What is Warfarin used for?
The effect of this block is to inhibit the synthesis of clotting factors.
Used clinically to prevent blood clots after surgery and to treat atrial fibrillation.
Drugs with -setron suffix do what?
Competitive inhibitors of Serotonin 5HT-3. Treat Nausea and vomiting.
What does Memantine do?
Open channel blocker of NMDA receptors.
This drug is a positive allosteric modulator and it can be prescribed for sleep for years without a waning of the effect
Zolpidem
azepam or ..azolam suffix is seen in what drugs?
Benzodiazepines
What receptor does Penicillin produce major side effects on?
Blocks the open channel GABAA receptor channel and inducing seizures.
What does strychnine do?
It is a glycine receptor competitive inhibitor.
What does tetanus toxin do?
It is a presynaptic inhibitor of glycine receptors.
What receptor is effected by the disease hyperekplexia?
Glycine receptors. Mutated alpha subunits.
Fluticasone and drugs with a -son or -one suffix bind where?
Cytoplasmic glucocorticoid receptor.
Where does minoxidil do?
Activation of KATP channels by minoxidil causes membrane hyperpolarization, closure of voltage-gated calcium channels, and vasodilation
What does tetrodotoxin (TTX) do?
Blocks voltage-gated Na+ channels in nerve and muscle (TTX acts like a plug at the extracellular surface of the voltage-gated sodium channel)
What do local anesthetics do?
Blocks the voltage-gated Na+ channel associated with the action potential. (The main difference between local anesthetics and TTX is that local anesthetics preferentially bind to the inactivated state of the Na+ channel)
Where are Furanocoumarins found and what do they do?
found in grapefruit inhibit CYP3A4 and p-glycoprotein
