FCPS Pearls 2 Flashcards
Actin binds to Z disc via
Actinin protein
Actin binds to Z disc via
Actinin protein
Cross-bridge in sarcomere of skeletal muscles are made up of
Myosin
Phases of action potential cycle in atria, ventricles and Purkinje fibers
- Phase 0 - Depolarization
- Phase 1 - Initial repolarization
- Phase 2 - Plateau
- Phase 3 - Rapid repolarization
- Phase 4 - Resting membrane potential
Phases of action potential cycle in SA node
- Phase 0 - Upstroke
- Phase 1 and 2 - Absent
- Phase 3 - Repolarization
- Phase 4 - Slow depolarization
Heart ventricles decreased upstroke is due to
Prolonged opening of Na channels
Regarding Cat-electrotonic potential
All or none potential
About astrocytes action potential
Action potential is generated with increased intracellular potassium
Cytoskeleton to ECM
Integrin
Cytoskeletal ECM to ICM
Intermediate filament
ECM to ICM
Integrin
Cell to cell adhesion
Cadherin
Firm adhesions are by
LFA-1 > integrin
Transient adhesions are mediated by
Selectins
Desmosomes are made up of
- Cytokeratin
- Cadherin
- Intermediate filaments
If a drug molecular weight is less than 100 Da, transport occurs via
Diffusion
If a drug molecular weight is 100 Da or more, transport occurs via
Pinocytosis
Primary active transport vs secondary active transport
Primary AT requires ATP
Secondary AT requires electrochemical gradient
Fructose is absorbed in intestine via
Facilitated diffusion
Glucose and amino acids are absorbed in duodenum and jejunum via
Active transport
Chloride is absorbed in PCT by
Passively by electrochemical gradient
Glucose is absorbed in the kidney via
Secondary active transport
Glucose and amino acids are absorbed in PCT via
Active transport
The diffusion capacity of pulmonary capillaries increases in (normal and abnormal)
- Increase in alveolocapillary surface area
- Polycythemia
Types of cells on the basis of their dividing capabilities
- Labile cells
- Stable cells
- Permanent cells