Fat Metabolism Flashcards
How are the ketone bodies formed in ketosis
Too much FA for liver to take in, more acetyl CoA is made but not enough oxaloacetate to combine so excess converted to ketone bodies
What’s ketosis
Build up of excess ketone bodies which decreases pH of blood
What’s the most common metabolic disorder in lactating cows
Ketosis
What enzyme is used to cut off FA in cleavage step
Thyolase
What is used to move FA across mitochondrial membrane in cleavage step
Carnitine
What does ATP covert to in beta oxidation
AMP
How many ATP is used in the activation step of beta oxidation
2
How does activation happen in beta oxidation
Binding of FA to CoA to form acetyl CoA
What are the two steps to beta oxidation
Activation
Cleavage step
Where does beta oxidation happen
Mitochondria
What is glycerol converted to and where in lipolysis
Glucose in liver - gluconeogenesis
What hormones activate lipase
Glucagon, adrenaline
What are the post absorptive states
Lipolysis
Beta oxidation
What does HDL transport and where
Excess cholesterol from cell to liver
What does LDL transport and where
Cholesterol to cells
Where do chylomicrons transport TG
From GI into lymph and then blood
What are the different lipoproteins
VLDL, LDL, HDL, chylomicrons
