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Genetica > Farmacogenetica > Flashcards

Farmacogenetica Flashcards

1
Q

Absorbtia medicamentelor este controlata de doua clase de proteine:

A 
Solute carrier( SLC)
ABC( ATP-binding casette)
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2
Q

Proteine care transporta medicamente intracel.

A

SLC

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3
Q

Pompe de eflux celular

A

ABC

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4
Q

Proteine ABC exprimate abundent la nivelul:

A

Enterocite, celule epiteliare renale, epit. Canalicule biliare

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5
Q

Familile de proteine ABC

A

ABCB
ABCC
ABCG

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6
Q

Familia ABCB

A

MDR multiple drug resistance

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7
Q

ABCC

A

MRP multiple drug resistance associated proteins

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8
Q

ABCB1

A

Glicoproteina P

MDR1

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9
Q

EXTENSIVE METABOLIZER

A

individ homozigot normal

alele tip wild type-izoforma enzimatica cu activitate normala

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10
Q

Intermediate metabolizer

A

Heterozigot
O alela wild type- enz normala
O alela mutanta- enz proasta

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11
Q

Poor metabolizer

A

Homozigot mutant/ hetero compus

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12
Q

Ultra extensive metabolizer

A

Mai mult de 2 alele normale

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13
Q

Sistem enz principal metab med

A

P450

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14
Q

Reactii de faza 1

A

Hidroliza oxidare reducere

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15
Q

Faza 2 reactii

A

Conjugare

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16
Q

Superfamilia de gene care codifica P450

A

Gene CYP

17
Q

Isoforma CYP2C9

A 
Polimorfa
Anticoagulante orale 
AntiD orale
Antiepileptic( fenitoina)
AINS
18
Q

CYP2C19

A

Inhibitori de pompa de H+ ( omeprazol, pantoprazol, lansoprazol…)
Antidepresive-inhibitori recapt. serotonina( fluoxetina)
Antiepileptice
Inhib proteaza HIV
Antimicotice
Antiagregantul plachetar clopidogrel

19
Q

CYP2D6

A 
Antidepressants 
Statine
Analg. Opioide
AntiHTA
Antiestrogenicul TAMOXIFEN
20
Q

Profilaxie cancer de san plus cyp

A

Tamoxifen

CYP2D6

21
Q

Analogi pirimidinici cancere epit

A

5 fluorouracil

Capecitabina

22
Q

UGT

A

Glucuronidare subst. Endobiotice si Xenobiotice

23
Q

UGT1A1

A

Metab. Bilirubina
Sindr. Gilbert Criegel-Najal 1 2
Important- irinotecan-citostatic

24
Q

NAT2 relatii med

A

Hidralazina-vasodil.

Isoniazid- tuberculoza

25
Q

Tiopurine(prodroguri)

A

Imunomodulatoare- boli AI

Citostat-leucemii acute

26
Q

TPMT

A

Metab tiopurine

27
Q

Primul med. Biologic

A 
Imatinib mesylate( gleevec)
Inhibitor de tirozin kinaze- BCR-ABL
28
Q

Vemurafenibul

A

Med bio

Asupra cel maligne prot. BARF anormala- melanom metastatic

29
Q

Cetuximab

Pamitumumab

A

Cancer colo-rectal metastatic
AC monoclonali impotriva EGFR
Mutatii KRAS=> rezistenta

30
Q

Chimioterap cancer pulm

A

Molec anti EGFR-erlotinib, geftinib
Exceptie cancer pulm cu cel mici
Doar la pac. Cu mutatii +egfr

31
Q

Amplificatea genei HER 2 cancer mamar

A

Tratament transtuzumab- Ac monocl

32
Q

Raspuns anticoag. Orale ( warfarina acenocumarol)

A

Inr: sex varsta greytate fg
Faza 1 CYP2C9
FAZA 2: VKORC1( TINTA LOR VITAMIN K EPOXID REDUCTAZA)

Genetica (2 decks)

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