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K4 - Blod > Farma > Flashcards

Farma Flashcards

1
Q

Rituximab

A

Muse/humant monoklonalt CD20-antistof, (CD20 udtrykkes på modne B-celler).
Gives som iv. infusion i kombination med kemoterapi til behandling af maligne B-celle lymfomer eller alene som vedligeholdelsesbehandling
Anvendes også til steroid resistent ITP, AIHA samt til ALL, med CD-20 positive lymfoblaster
Har forårsaget signifikant forbedret overlevelse af flere lymfom undertyper bla. den højmaligne Burkit lymfom sygdom
Bivirkninger: (Akutte) Feber, kulderystelser, hypotension (Sene) Øget infektionstendens (efter gentagne serier)

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2
Q

Ofatumumab

A

Fuldt humant antistof. Nu indregistreret til resistent CLL

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3
Q

Alemtuzumab (Mabcampath)

A

Antistof mod CD52 (udtrykkes på lymfocytter, thymocytter (tidlige t-lymfocytter), monocytter, makrofager)

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4
Q

Brentuximab

A

Nyt lovende CD30-antistof til især refraktær/relaps mb. Hodgkin.

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5
Q

Calicheamicin: Mylotarg

A

Anti CD33 mod myeloide celler.

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6
Q 
Ange vad vilka celler som har markörerna: CD34: Stamcellerna - Myeloid, Lymfoid, Myelo-monocytär stamcell. 
CD34+33: 
CD42+61:
CD13+33+14: 
CD13+33+15: 
CD3: 
CD20:
A

CD34: Stamcellerna - Myeloid, Lymfoid, Myelo-monocytär stamcell.
CD34+33: Pro-megakaryoblast
CD42+61: Megakaryoblast-> II -> Megakaryocyt
CD13+33+14: Monoblast -> Promonocyt -> II -> Monocyt
CD13+33+15: Myeloblast -> Promyelocyt -> Myelocyt -> Granulocyt
CD3: T-cell
CD20: B-celle

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7
Q

Anagrelid

A

Anagrelid – hæmmer modning af megakaryocyter

Behandling af PV og ET

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8
Q

Hydrea

A

Hydrea – kemoterapi, anti-metabolit i DNA-syntesen. Behandling af PV, ET.

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9
Q

INF-alpha (funktion ved behandling af PV og ET?)

A

Hæmmer de proliferative forstadier i myeloide stamceller

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10
Q

Myleran

A

Kemoterapi-preparat som er leukæmiogent

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11
Q

Ruxolitinib

A

Ny JAK-2-hæmmere som bruges i behandling af IMF (NYT! Så ikke helt alment)

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12
Q

Imatinib

A

Glivec! BCR-ABL tyrosinekinase-hæmmere! Effektiv i CML!

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13
Q

Tamoxifen

A

Hæmmer estrogen-receptorn i brystkraft. Agonist i endometriet og knoglevæv. 1x tablet per dag + aromatasehæmmere (som producerer østrogen) t ex letrozol

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14
Q

Letrozol

A

Aromatasehæmmere (som ellers producerer østrogen) som bruges i kombination af Tamoxifen i ER+ brystkræfter

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15
Q

Rivaroxaban

A

Faktor Xa-hæmmere

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16
Q

Fondaparinux

A

i.v. faktor Xa-hæmmere

17
Q

Dabigatran

A

Thrombin-hæmmere

18
Q

Phenprocoumon

A

Vitamin K-antagonist

19
Q

Clopidogrel

A

hæmmer optagelsen (og deraf aktivering) af ADP til trombocytter!

20
Q

ASA

A

COX-hæmmere som altså inhiberer produktion af Thromboxane A2 som aktiverer fibrinogen-receptorn og aggregering. TXA2 øger også ADP-produktion som også stimulerer GP IIa/IIIb-receptorn (fibrinogen-receptorn)

K4 - Blod (2 decks)

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