farm

Question 1

snri(serotonin norad reuptake inhibitor)

Answer 1

4. desvenlafaxine duluoxetine venlafaxin levomilnacipram. TCAs and amoxopine-also d antagonist
   moa: block SERT and NET

Question 2

ssri(selective seretonin reuptake inhib)

Answer 2

7. citalopram escitalopram fluoxetine paroxetine sertraline
   vilazodone-partial agonist 5ht-1a, vortioxetine-partial agonist 5ht-1b full agonist 5ht1a and full antagonist 5ht1d,3,7.
   fluvoxamine-ocd

moa: blocks sert

Question 3

other indications

Answer 3

nicotine withdrawal-buproprion, enuresis imipramine, duloxetine-ssri-diabetic neuropathy fibromyalgia musck pain stress incontinence

Question 4

ndri(norepi da reuptake inhibitor)

Answer 4

1. bupropion-nicotine withdrawal. also increase ne/da presynaptic release

moa: Block NET and DAT
increase presynaptic NE and DA via VMAT

Question 5

sara(serotonin adren receptor antag)

Answer 5

both block h1(sedation)

trazadone and nefazodone: ssri action, block post synaptic a1 receptor on NE neuron, block post synaptic 5ht2 receptors on 5ht neuron

mirtazipine: blocks presynaptic a2 receptors on NE and 5ht neurons, blocks post synaptic 5ht2/3 receptors. no sert and NET

Question 6

maoi(monamine oxidase inhibitor)

Answer 6

isocarboxazid phenelzine selegiline-selective at low/mod does non selective at high doses and is in patch form, tranylcypromnine

Question 7

finish

Answer 7

withdrawal sx of all antidepressants, ie missing doses.  deprescribe.
flu like sx
insomnia
nausea
imbalance
sensory disturbances
hyperarousal

Question 8

which 2 agents affect dopamine pthwy

Answer 8

bupropion, ndri, blocks reuptake, increases presynaptic release
amoxapine: dopamine antagonist

Question 9

serotonin syndrome

Answer 9

ssri. increasesed risk with other serotonin affecting agentsmaybe opiods.

SHAS
sweating
hyperreflexia
akathisia monoclonus
shivering/tremors

Question 10

side effects of ssri

Answer 10

CNS, sedation or insomnia/agitation/nervousness
sexual dysfunction
weight gain
finish
qt prolongation, SIADH like hyponatremia(rare, toxic settings)
serotonin syndrome SHAS
suicidality(attempts completions, higher in younger)

Question 11

ssri drug interaction

Answer 11

most-fluoxetine
least-vortioxetine escitalopram
low/mild-citalopram sertraline vilazodone

Question 12

tca

Answer 12

part of snri
3 amine,
amit(riptyline) clomi(pramine) doxe(pin) imipramine

2 amine
amoxapine desi(pramine) nortrip(tyline)

moa: snri.
side effects, nonefficacy related block of
H2: CNS, sedation/fatigue, dizziness/seizures
M: anticholinergic, dry mouth, urinary retention/constipation, blurred vision
a1: cardiovascular, tachycardia, ortho hypotension, dysrhythmia

Question 13

TCA 3 c’s

Answer 13

coma, cardiotoxicity(conduction abnormalities)-qunidine like, convulsions

Question 14

snri side effects

Answer 14

similar to ssri, less risk of sexual dysfunction

Question 15

SARA side effects

Answer 15

CNS sedation w/trazodone/mirtazapine
ortho hypotension w/trazodone
weight gain w/mirtazapine

Question 16

NDRI side effect

Answer 16

buproprion.  
agitation/insomnia(stimulation)
hypertension/tachy
weight gain
seizure(dose Dependent)-starred