FANA Profile Flashcards
Are FANA profile tests highly specific or highly sensitive?
Highly specific (few false positives), not highly sensitive (many false negatives)
unusual antibodies detectable in the blood, that have the capability of binding to certain structures within the nucleus of the cells
antinuclear antibodies
What does a positive FANA indicate?
Systemic autoimmune disease, organ-specific autoimmune disease, or connective tissue disorder
A homogenous staining pattern most common in what conditions?
Sjogren’s syndrome and systemic lupus erythematosus
A speckled staining pattern is most often seen in what conditions?
Mixed CTD, Scleroderma, Sjogren’s syndrome, SLE, Polymyositis, RA
A centromere staining pattern is most common in what condition(s)?
Limited systemic sclerosis
A nucleolar staining pattern is most common in patients with what conditions?
Scleroderma, Polymyositis
What is the difference between ENA (Extractable Nuclear Antibody) with and without R’nase?
Used to distinguish ribonuclease sensitive and insensitive ENA (this test is used to distinguish between MCDs and SLE).
Most patients with positive anti-RNP antibody have one of what two conditions?
MCD or SLE
Positive ENA w/ R’Nase but not ENA w/o R’Nase indicates what?
SLE (and these SLE patients typically demonstrate increased incidence of Raynaud phenomenon.
Which antibodies are usually diagnostic for scleroderma?
Scl-70 (can also be found in other conditions such as SLE)
Which antibodies are diagnostic for lupus (SLE)?
ds DNA (usually; can also be scleroderma)
Scl-70 antibodies are most associated with what condition?
scleroderma (highly specific for this disease)
Which antibodies are most associated with Sjogren syndrome?
SSA/Ro Ab and SSB/La
What kind of antibodies target beta-2 glycoprotein?
Anti-phospholipid antibodies
