Family medicine rotation Flashcards
Gouty arthritis vs pseudogout?
Gouty arthritis: MSU crystals in joints due to excess uric acid esp in great toe
Pseudogout: Calcium pyrophosphate dehydrate crystals in joints (dx by rod-shaped, rhomboid, WEAKLY birefringence by crystal analysis)
Factors that can induce hyperuricemia/to take into consideration when considering gout attacks?
Men 30-50yo
Women 50-70yo
- Recent increase in alcohol consumption
- Large meal (esp if red meat, liver or seafood since they are high in purines)
- Trauma, surgery
- Recent h/o thiazide diuretic use
Compare calcium pyrophosphate dehydrate vs calcium hydroxyapatite vs calcium oxalate crystals
calcium pyrophosphate dehydrate:
- Rod shaped
- Rhomboid
- Weakly positive birefringence
Calcium oxalate:
- Bipyramidal
- Mostly seen in ESRD pts
- Strongly positive birefringence
Calcium hydroxyapatite:
- Seen by electron microscopy
- Cytoplasmic includions that are NON-birefringent
Gross appearance of joint aspirate is essential/non-essential for diagnosis of septic arthritis. T/F?
FALSE
- Both septic aspirate and a heavily condensed crystal-induced arthritis may have a thick, yellowish/chalky appearance
- *Thus gross appearance of fluid is NOT very specific
- **To dx crystal-induced arthritis you need polarizing microscopy to reveal MSU crystals
How do labs help you distinguish crystal induced arthritis from septic joint?
Crystal induced joint aspirate will have avg 2,000-60,000/uL WBCs with 90% PMNs
DDx for nontraumatic swollen joint?
Gout (or any crystal induced arthritis)
Infectious arthritis
OA
RA
Likely bacteria responsible for joint infections in HIV+ patients? IVDU?
HIV+
- Pneumococcal, salmonella, H. influenzae
IVDU
- Streptococcal, staphylococcal, gram negative, or Pseudomonas
Septic joint will have a very limited ROM. T/F?
True; limited ROM due to pain
*Maintain ROM in cellulitis, bursitis, or osteomyelitis
OA is most commonly seen in people older than ____ years and is associated with ___
>65yo Associated with: - Trauma - Obesity (esp for knee OA) - H/o of repetitive joint use
When is an ultrasound indicated in pregnancy?
Uncertain gestational age Size/date discrepancies Vaginal bleeding Multiple gestations Other high-risk situations
How much radiation is too much for a pregnant woman? Are MRIs safe?
> 5 rad; associated with fetal harm
(e.g. dental x ray is .00017 rad)
Fetus particularly sensitive to radiation during 2-15 weeks after conception
*MRIs are NOT shown to be harmful but not recommended
How much folic acid should women take if they are thinking of getting pregnant?
Should start folic acid supplement at least 1 month prior to attempting to conceive
- Low risk women: 400-800ug daily
- Women who has had child with NT defect: 4mg daily
How do you determine the estimated delivery date? When should you obtain this?
Obtain at initial prenatal visit
- Get history; get first day of last menstrual period (LMP)
- Use Naegele’s rule: from first day of LMP subtract 3 months and add 7 days
- Make sure LMP is reliable:
- Date is certain
- LMP was normal
- No contraceptive use in the past 1 year
- Pt has had no bleeding since LMP
- Regular menses
- **Not reliable LMP? Get ultrasound!
When should you be able to hear heart tones in a fetus?
10 week gestation using handheld doppler fetoscope
Initial lab screen for pregnant women should include which tests?
CBC Blood type Rh status Rubella HIV Hep B surface antigen Rapid plasma reagin UA Urine culture Pap smear Cervical swab for gonorrhea and chlamydia
How often should prenatal visits happen?
Typical protocol:
- Every 4 weeks until 28 weeks gestation
- Every 2 weeks from 28-36 weeks
- Every 1 week from 36 weeks-delivery
Approximate sensitivity and specificity of triple screen? When is it done and what does it screen for? Most common cause of false-positive serum screen?
Triple Screen
- Sensitivity: 65-69%
- Specificity: 93%
Between 15-20 weeks, preferably 16-18 weeks
Screens for:
- Trisomy 18
- Trisomy 21
- Neural tube defects
*Most common cause of false-positive is INCORRECT GESTATIONAL AGE
Risk factors for increased risk of aneuploidy?
- Women older than 35 at delivery if singleton pregnancy (32 if twins)
- Women carrying fetus with major structural anomaly identified by US
- Women with US markers of aneuploidy including increased nuchal thickness
- Women with previously affected pregnancy
- Couples with a known translocation, chromosome inversion, or aneuploidy
- Women with positive maternal serum screen
***Offer prenatal dx by amniocentesis or chorionic villus sampling
Most trisomy 21 fetuses are born to mothers older than 35 at time of delivery. T/F?
FALSE
Trisomy 21 increases with maternal age but 75% of affected fetuses are born to mothers YOUNGER than 35 at time of delivery
When should women be screened for group B strep?
ALL women should be offered GBS screening by vaginorectal culture at 35-37 gestation (swab lower vagina, perineal area, and rectum)
If colonized, treat with IV antibiotics at time of labor or rupture of membranes in order to reduce risk of neonatal GBS infection
At what week gestation should you consider induction of labor to reduce risk of neonatal mortality and morbidity?
42 weeks (twice weekly testing for fetal wellbeing in prolonged pregnancy recommended at 42 week gestation)
Influenza vaccine is safe in any stage of pregnancy. T/F?
True
provided they have no allergy to its components
When do you give RhoGAM to a pregnant woman?
Women who are Rh negative and if antibody screen or indirect Coombs test is negative –> then give RhoGAM at 28 weeks gestation and again at delivery if the baby is confirmed as Rh positive
*RhoGAM is given to prevent isoimmunization
How is failure to thrive defined?
Weight below third or fifth percentile for age
or
Decelerations of growth that have crossed two major growth percentiles in a short period of time
You should take blood pressures of children older than age 3. T/F?
True
If less than three, measure and plot head circumference to monitor growth
States vary in terms of which congenital diseaes to screen for but all states require testing for ______
PKU and congenital hypothyroidism
*since early treatment can prevent development of profound mental retardation
Most common cause of anemia in children?
Iron deficiency
Risk factors for iron deficiency anemia in children?
Drinking more than 24oz of cows milk
Iron-restricted diets
Low birth weight or preterm
Mother who was iron deficient
Leading cause of death in children older than 1 year?
Accidents and injuries
Until when should a child sit in a rear facing car seat?
Until they are both 1 year old AND weighs at least 20 bs
Older than 1 and between 20-40lbs should be in forward-facing car seat
> 40lbs, child can use booster type seat + lap and shoulder seat belt
*NO CHILD IN THE FRONT SEAT UNTIL 13yo OR OLDER
Leading cause of death in infants younger than 1 year?
Sudden infant death syndrome
- Advise parents to place infant on back on firm mattress with nothing else in crib
- *Heavy coverings and soft mattresses are associated with increased risk of SIDS
Leading cause of blindness worldwide?
Cataract disease
Leading cause of severe vision loss in elderly?
AMD
Leading cause of blindness in working-age adults in US?
Diabetic retinopathy
What is otosclerosis? What age group do you see this in?
Autosomal dominant disorder of bones in the inner ear –> progressive conductive hearing loss
Onset in late 20’s to early 40’s
Pt has central auditory processing disorder. Would you expect them to be able to understand what you say?
No, they have difficulty understanding spoken language BUT may be able to hear sounds well
____% of non institutionalized elderly fall each year.
30%
Pt older than 80 yo has a ___% annual risk of falls
50%
How does dementia prevalence change as you age?
Doubles every 5 years after 60yo
By 85yo, 30-50% of people have some degree of impairment
What are some rapid and fairly reliable office based screenings for dementia?
Clock draw and three-item recall
*fail? further test with MMSE
Incontinence affects more men than women. T/F?
False
Men 11%-34%
Women 17-55%
Depressive symptoms are more common in elderly vs younger populations. T/F?
True
Depressive symptoms = MORE prevalent vs younger populations
MDD = LESS prevalent vs younger populations
What is the HHIE-S?
Hearing Handicap Inventory for the Elderly
- An initial office screening for general hearing loss with reliability
A whispered voice test has low sensitivity when evaluating for hearing loss. T/F?
False;
Sensitivities and specificities range from 70-100%!
What is the next step if an elderly patient gives you a positive response to “Have you felt down/depressed/hopeless in the last 2 weeks? Have you felt little interest or pleasure in doing things?”
Follow up with a Geriatric Depression Scale
30 question instrument that is sensitive, specific, reliable for dx of depression
___% of hospitalized elderly are malnourished.
50%
vs 15% of older outpatients
How do you assess nutritional status in elderly?
MOST USEFUL METHODS:
Serial weight measurements in the office
Inquiry about appetite
Protein undernutrition is commonly seen in the ____ setting. Protein undernutrition is associated with an increased risk of:
Nursing home elderly have a 17-56% prevalence of protein undernutrition.
Associated with: Infections Anemia Orthostasis Decubitus ulcers
_____ are the drug of choice in treating hypertension.
Thiazides (unless a comorbid condition makes another choice preferable)
_____ and ____ are the leading causes of death in the elderly.
Heart disease
Cerebrovascular disease
How does stroke incidence in older adults change with age?
Roughly doubles every 10 years
What are the 2 greatest risk factors for stroke?
#1 Hypertension #2 Atrial fibrillation (warfarin reduces risk of stroke in those with afib)
Screening elderly men for prostate cancer is routinely recommended. T/F? Why or why not?
False
Not definitely shown to prolong life
Risk of incontinence or erectile dysfunction caused by treatments
How often should an older woman get a mammography?
Every year until life expectancy falls below 5-10 years
How often should colon cancer screening happen?
Colonoscopy every 10 years OR
Annual fecal occult testing + flexible sigmoidoscopy every 5 years
Can be stopped when life expectancy is less than 5-10 years
When can you stop screening for cervical cancer?
Women older than 65-70 who have had 3 NORMAL PAPS over the preceding 10 years
Osteoporosis risk factors?
Older age Female White or Asian Low calcium intake Smoking Excessive alcohol use Chronic glucocorticoid use
How to reduce risk of osteoporotic fractures in both men and women?
Calcium carbonate (500mg TID) Vit D (400-800 IU/day)
What is DEXA and when would it be used?
Dual-energy x-ray absorptiometry
- Tests for bone mineral density; may uncover asymptomatic osteoporosis in patients with multiple risk factors
Who should get flu vaccines?
Everyone over 6mos, annually
One dose of herpes zoster vaccine is recommended at age ____
60 or older
Persons older than age 65 should receive at least ______ (immunizations)
One pneumococcal immunization
Single booster of tetanus and diphtheria
Oral advanced directives are legally binding. T/F?
Oral statements are ethically binding but NOT legally binding in all states
*Written AD’s are essential so as to give effect to the patient’s wishes in these matters
How effective is CPR?
Only ~15% of all patients who undergo CPR in the hospital survive to hospital discharge
CPR may result in fractured ribs, _____ and _____
Lacerated internal organs
Neurologic disability
Presentation of presbycusis?
Symmetrical high-frequency hearing loss
Loss of speech discrimination
Difficulty understanding rapid speech, foreign accents, conversation in noisy areas
*Sensorineural mechanism, rather than conductive
Hallmark physical exam finding in hypertrophic cardiomyopathy?
Systolic murmur that DECREASES in intensity with the athlete in the supine position (increased ventricular filling, decreased obstruction)
*Functional outflow murmurs increase in intensity upon lying down
How would the intensity of an HCM murmur change with the Valsalva maneuver?
Increase!
Valsalva –> decreased ventricular filling, increased obstruction
Most murmurs will decrease in intensity and duration with valsalva. T/F?
True
How is the HPV vaccine given? What does it protect against?
3 injections over 6 months
Immunization again 4 strains (6, 11, 16, 18)
- 6, 11 for venereal warts
- 16, 18 for cervical dysplasia/cancer
What is GAPS?
Guidelines for Adolescent Preventive Services
- Series of recommendations regarding delivery of health services, promotion of well-being, screening for common conditions, and provision of immunizations for adolescents and young adults between 11-21 years old
According to GAPS, all adolescents should be screen for eating disorders, obesity, tobacco/alcohol/drug use, AND hypertension. T/F?
True
Annual hypertension screening and treat those above 90th percentile for gender and age
Routine toxicology and lipid screening is recommended for all adolescents according to GAPS. T/F?
False
- Tox screening not recommended
- Lipid screening recommended for above-avg risk based on PMH of comorbid conditions or Family Hx of HLD, CAD, or other vascular diseases