Family Medicine Flashcards
ABCD of Melanoma
a - asymmetry (symm vs asymm)
b - border (defined vs ragged)
c - color (uniform vs variegated)
d - diameter (less vs greater than 6 cm)
tx for benign melanoma
monitor
educate patient
tx for suspicious melanoma
excise with 2-3 mm margin
how do you excise malignant melanomas
5 mm margin
if on face, refer to plastic surgeon
what is follow-up after excising a melanoma
annual follow-up
observe for new/changing lesions
most important prognostic indicator for melanoma
thickness of tumor
(aka breslow measurement)
less than 1mm thick has low rate of metastasis
how to prevent melanomas
reduce exposure to UV radiation
clothe properly
sun-screen
describe basal cell carcinomas
pearly papules
central ulceration
multiple telangiectasias
bleeds or itches
tx for bcc
excision
rarely metastasizes
which metastasizes more: scc or bcc
scc
describe scc
irregularly shaped plaques or nodules with raised borders
scaly
ulcerated
bleed easily
tx for scc
excision
how do you image the upper urinary tract
IV Pyelo
how do you image the lower urinary tract
cystoscopy
define microscopic hematuria
> 3 RBC per HPF
from 2-3 Ua tests
freshly voided
morning
clean catch
midstream urine
eos in the urine
interstitial nephritis
how long does exercise-induced hematuria last
less than 72 hours
pt with hematuria, has repeat Ua showing hematuria again, what do you do next
full work-up
Ua
microsopy of urinary sediment
Ucx to r/o UTI
BMP to get Cr –> focus on renal cause if elevated (May need renal bx)
what exactly is an IVP
x-ray of urinary tract after administration of contrast
CT with or without contrast to look for calculi
non-con
complication of CT with con or IVP
risk factor for it
how do you prevent it
nephropathy
renal insufficiency
premedicate with N-acetylcysteine
if patient has renal insuff, whats another way to evaluate for upper urinary tract
retrograde pyelography with renal ultrasound
place catheter in the bladder and inject contrast up ureter to kidneys
how do you examine for transitional cell carcinoma
cystoscopy
patient with hematuria, but with a thorough negative work-up
what do you do now?
do BP measurements
Ua
voided urine ctyologic studies
all done at 6, 12, 24 and 36 months
basically you`re looking for any underlying lesions, after this if they are still asymptomatic, then no further tests required
however, if they still have sx (i.e. hematuria, dysuria, develops HTN, proteinuria, casts), refer to urologist
is radioactive iodine therapy safe in pregnant woman
no
radioactive isotope can cross placenta and cause fetal thyroid ablation
alternative: surgical removal of thyroid
meds for graves
antithyroid drugs (PTU and methimazole)
beta-blockers to counter peripheral effects
these are only temporary
definitive tx for graves
radioactive iodine
destroys thyroid gland
signs and sx
thyroid storm
fever
confusion
restlessness
psychotic-like behavior
tachycardia elevated BP dysrhythmias dyspena on exertion peripheral vasoconstriction
Signs and sx of hyperthyroidism
nervous palpitations wt loss fine resting tremor dyspnea on exertion difficulty with concentration
50% of graves has this finding
exophthalmos
how do you diagnose hyperthyroidism
low TSH
high Free T4
you suspect graves dz
whats your next step
imaging with technetium-99
its a radionucleotide scan
tells you active/inactive areas
usually DIFFUSE uptake
radionucleotide scan in thyroiditis vs graves
graves - diffuse uptake
thyroiditis - patchy uptake
how does PTU and methimazole work?
inhibits organification of iodine
PTU also prevents peripheral conversion of T4 to T3
side effect of PTU and methimazole
agranulocytosis
Are PTU and methimazole safe during pregnancy?
YES
PTU is preferred however
for graves, when is surgery indicated
pregnant women
cannot tolerate side effects of PTU
large goiter compressing nearby structures
signs and sx of hypothyroidism
lethargy weight gain hair loss dry skin slow mentation/forgetfulness constipation intolerance to cold depression
in elderly, differential dx for dementia
alzheimers
hypothyroidism
side effect of PTU and methimazole
agranulocytosis
is PTU and methimazole safe during pregnancy
YES
PTU is preferred however
for graves, when is surgery indicated
pregnant women
cannot tolerate side effects of PTU
large goiter compressing nearby structures
signs and sx of hypothyroidism
lethargy weight gain hair loss dry skin slow mentation/forgetfulness constipation intolerance to cold depression
in elderly, differential dx for dementia
alzheimers
hypothyroidism
in women, differential dx for depression
depression
hypothyroidism
physical findings of hypothyroidism
low BP bradycardia nonpitting edema hair thinning or loss dry skin diminished relaxation of reflexes
Most common cause of hypothyroidism
Hashimoto thyroiditis
what are secondary causes of hypothyroidism
hypothalamic or pituitary dysfxn
pts received intracranial irradiation or surgical removal of a pituitary adenoma
dx of primary and secondary hypothyroidism
primary:
high TSH
low Free T4
secondary:
low tsh and free T4
how would you distinguish between hypothalamic vs pituitary hypothyroidism
inject TRH
if TSH increases, its a hypothalamus problem
if TSH remains low, its a pituitary propblem
as you age, you may need to decrease levothyroxine dosage
why?
thyroid binding to albumin decreases b/c albumin also decreases with age
monitor TSH annually in elderly
you find thyroid nodules on PE
what do you do next?
why?
evaluate thyroid fxn (tsh/t4)
functional adenomas with hyperthyroidism are rarely malignant
to rule out malignancy in solitary nodules
risk factors for thyroid malignancy
history of head/neck irradiation
family hx of thyroid cx
cervical LA
recent development of hoarseness of voice
tx for hyperfunctioning thyroid nodules
surgery
radioactive ablation
nonfunctioning thyroid nodules
what do you do next?
assuming you found this nodule by ultrasound or physical exam
FNA biopsy
FNA of thyroid nodule is INDETERMINATE
whats the next step
you need a definitive dx by surgery only
this is b/c indeterminate means that you cannot distinguish between follicular cell malignancy from its benign equivalent
tx for thyroid malignancy
thyroidectomy
followed by radioactive ablation
pregnant woman with thyroid nodule
next step?
FNA to find out what it is
thyroidectomy is SAFE
radioisotope scan is CONTRAINDICATED
or just wait til postpartum period b/c thyroid cancer is relatively indolent
tx for GBS during pregnancy
penicillin
others: ampicillin, cephalothin, erythromycin, clinda
how to confirm rupture of membranes
see amniotic fluid leaking from cervix
polling of amniotic fluid in vaginal fornix
Nitrazine paper - pH >6.5 in vaginal fluid
ferning on dried slide
prolonged rupture of membranes predisposes to what
infection
define first stage of labor
contractions until complete cervical dilation
latent phase
active phase - starts at 4cm
rate of dilatation
epidural vs nonepidural
NO EPIDURAL
- 2cm / hr (nulliparous)
- 5cm / hr (parous)
define second stage of labor
delivery of fetus
normal duration of 2nd stage of labor
2 hours (nulliparous) 1 hour (parous)
epidural can prolong these times by 1 hour
Normal duration of 3rd stage of labor
30 min
labor depends on 3Ps
power (strength of contractions)
passenger (size, lie, position)
pelvis (shape and size)
what can cause of false-positive nitrazine test
semen
blood
bacterial vaginosis
all can elevate pH
how do you assess fetal well being when mother is admitted to Labor and Delivery
fetal heart rate monitoring
with a doppler ultrasound
or fetal scalp electrode
(requires membranes to be ruptured)
what 3 things do you look at in fetal heart rate tracings
baseline heart rate
variability
heart rate changes
normal baseline heart rate of fetus
110-160
normal variability of fetus
3-5 cycles per minute
comomn causes of decreased fetal heart rate variability
fetus sleeping
cns depressants (narcotic analgesics)
prematurity
fetal acidemia 2nd to hypoxemia
define fetal heart rate accel
15 beats/min
15 sec
what causes early decels
compression of fetal head
what causes late decel
uteroplacental insufficiency
causes:
maternal hypotension (given epidural or oxytocin)
maternal HTN, DM, placental abruptio
what causes variable decel
umbilical cord compression during contractions
what do you use to monitor uterine contractions and its strength
external toco
strength: IUPC (need ruptured membranres)
giving too much oxytocin during labor can result in what consequence
uterine hyperstimulation
late decels
Cardinal movements during labor
refers to movement of fetal head
flexion
internal rotation (occiput to move anteriorly - symphysis)
extension
external rotation
maneuvers for shoulder dystocia
McRoberts Maneuver (hyperflexion of maternal legs)
suprapublic pressure
episiotomy
most calcium is found where in the body?
bones - 98% of total
bound to albumin - 1%
watch out for low albumin, causing low calcium (correct for this)
free - 1% (active)
formula for corrected serum calcium
corrected calcium =
[normal albumin - serum albumin] X 0.8(serum calcium)
what hormone decreases serum calcium and how?
calcitonin
causes increased renal excretion
what hormone increases serum calcium and how?
PTH
increases bone resorption by activating osteoclast
promotes kidney resorption
promotes GI absorption through calcitriol
most common cause of hypercalcemia
hyperparathyroidism
signs and sx
hypercalcemia
kidney stones
bone pain (arthritis, etc)
psychic (poor concentration, weakness, fatigue)
abdominal (pain, constipation, NV, pancreatitis)
first thing you look at when a pt has hypercalcemia
look at meds they`re taking
stop the suspected med
if a pt has hypercalcemia, what is the next step
order PTH
if PTH is low, feedback loop is working fine
if PTH is high or normal, feedback is not fine
(primary hyperparathyroidism)
how do you distinguish between primary hyperparathyroidism vs familial hypocalciuric hypercalcemia (FHH)
FHH is a genetic disorder
measure 24-hour urinary calcium
FHH: low calcium level
hyperparathyroidism: normal or elevated urinary calcium
if hypercalcemia, if PTH is low and Ca2+ is high, what lab test do you order next?
PTH-rP
parathyroid hormone related peptide
this is produced by cancers
lung, SCC of head and neck, kidney cx
how does PTH-rP work
osteoclast bone resorption
increases calcitriol (uptake in gut)
inc kidney resorption
tx for primary hyperparathyroidism
surgical removal of the adenoma
activities of daily living
bath dress eat toilet continence transfer from bed to chair
instrumental activities of daily living
transportation shop cook telephone manage money take meds housecleaning laundry
leading cause of blindness in elderly
age-related macular degeneration
what is macular degeneration
atrophy of cells in central macular region
leading to central vision loss
what is glaucoma
what is responsible for the disease
increased intraocular pressure
optic neuropathy
most common cause of blindness worldwide
cataracts
leading cause of blindness in working age adults in US
diabetic retinopathy
what is presbycusis
how does it present
age-related hearing loss
sensorineural hearing loss results in:
high-frequency loss
difficulty with speech discrimination
what is otosclerosis
autosomal dominant disorder of inner ear bones
loss of conduction
presents in 20-40s
speech discrimination is preserved
what is CAPD and contrast it with presbycusis
central auditory processing disorder
(CNS dysfxn)
has difficulty understanding spoken language
but hears sound well
quick cognitive screening test for dementia
clock draw
three-item recall
immunizations for ppl over 65
annual influenza
pneumococcal once
DPT booster
acute bronchitis
which antibiotic
none
antibiotics has not been shown to benefit
orgs in bacterial sinusitis (adults)
pneumococcus
h influenzae
orgs in bacterial sinusitis (children)
pneumococcus
h influenzae
moraxella catarrhalis
tx for acute sinusitis
first line
amoxicillin and bactrim
if fail, then 2nd line amoxicillin-clavulanic acid 2nd/3rd gen cephalo quinolones macrolides (azithro)
common causes of pharyngitis in teens/young adults
group A strep
mycoplasma pneumoniae
chlamydia pneumonia
arcanobacterium haemolyticus
group A strep findings
ABRUPT onset of sore throat/fever tonsillar/palatal petchiae tender cevical adenopathy NO COUGH sandpaperlike rash (scarlatiniform)
signs of
infectious mono
cervical and generalized adenopathy
HSM
atypical lymphocytes on smear
complication of infectious mono
splenic rupture to trauma
restrict sports
signs and sx
epiglottitis
cause?
stridor
drooling
toxic appearance
leaning forward (tripod position)
H influ
differential dx of tonsillar exudates
GAS EBV mycoplasma chlamydia adenoviruses
note: having tonsillar exudates does not automatically mean its bacteria vs virus
signs and sx
peritonsillar abscess
tonsil is pushed toward midline
uvula deviation
tx of peritonsillar abscess
surgical drainage
causes of peritonsillar abscess
strep
GAS
complications of GAS
rheumatic fever glomerulonephritis toxic shock syndrome peritonsillar abscess meningitis
does tx prevent poststreptococcal glomeruloneprhitis
NO
you can get it either way
tx for GAS
10-day course of oral penicillin
what is swimmer`s ear and what causes it
otitis externa
pseudomonas aeruginosa
Common causes of otitis media
s pneumo, h influe, m catarrhalis
tx for otitis media
aomxicillin
alternative
amox/clavu
bactrim
2nd/3rd gen cephalosporins
immediate tx for chest pain
MONA
morphine
oxygen
nitro
aspirin
beta blocker
how does cocaine induce angina?
coronary artery spasm
patient is on clopidogrel needs bypass surgery, what do you do next?
withhold clopidogrel for 5-7 days before surgery
what is unstable angina
what is the immediate treatment
angina at rest
give platelet inhibitors gIIb/IIIa
how are beta blockers helpful in MIs
reduces infarct size
decreases mortality
reduces risk of another one
how are ace-i helpful in MIs
reduces shor-tterm mortality if started within 24 hours of MI
prevents LV remodeling
hypomagnesemia increases risk of what
torsades de pointes
what is benefit of CCB in MIs
which CCB is contraindicated in MIs
none
nifedipine - increases mortality
diet for MI patients
low saturated fat and cholesterol
risk factors for CAD
DM HLD age HTN smoking family hx of CAD Male postmenopausal LVH homocystinemia
why give statins right after having ACS
decreases incidence of major adverse cardiovascular events
what is goal LDL if using statins after MI
minimum duration of exercise
30 min
minimum weight reduction to get benefits
5% minimum
Levine Sign
Holding fist to chest, sign of MI
unequal upper extremity pulses is a sign of what
aortic dissection
tx for elevated potassium
kayexalate
insulin
retention enemas
causes of chronic renal failure
DM
HTN
glomerulonephritis
drugs that affect kidney fxn
nsaids
aminoglycosides
contrast
in chronic renal failure, what is the first step in management
remove anything that reduces renal perfusion: hypovolemia (give IV fluids) hypotension infection --> sepsis drugs that lower GFR like nsaids
Goal of BP tx in chronic renal failure
Less than 130/80
what med do u treat BP with in chronic renal failure
ace-i
add diuretic if BP still not controlled
microscopic exam of trichomonas vaginalis
motile
flagellated
many wbcs
tx for trichomonas vaginalis
flagyl 2g one dose
and for partner as well
signs and sx
trichomonas vaginalis
green frothy discharge
strawberry cervix
vaginitis with recent abx use
what org is it
candida
vaginitis in a DM pt
what org is it
candida
describe candidal vaginitis
white discharge
no odor
VERY itchy
involves vulvar and vaginal areas (outside and inside)
tx for candidal vaginitis
single dose fluconazole
or
creams/vaginal suppositories
should you treat sexual partners of women with candidal vaginitis?
no, unless symptomatic
signs / sx
of gardnerella vaginalis
pH > 4.5
,positive KOH whiff test (fishy odor after adding KOH), clue cells on wet mount
tx for gardnerella vaginalis
metronidazole or clindamycin
oral or vaginal preparations
should sexual partners of gardnerella vaginosis be treated?
not necessary
as it does not reduce risk of recurrent infection
tx for gonorrhea
CTX
or Cipro
tx for chlamydia
doxycycline x 7 days
or azithromycin ONCE
and treat partners
PID
Pelvic Inflammatory Disease
signs and sx
NPH
urinary incontinence
gait disturbance
dementia
Contrast Lewy body dementia with Alzheimers dementia
Lwy body - hallucinations early on
tx for obesity
diet AND exercise….one alone is not good enough
Diagnostic components of metabolic syndrome (5)
waist > 40 in (men) or 35 in (women)
triglycerides >150
HDL 130/85
fasting glucose > 110
signs and sx
migraines
pulsating HA unilateral photophobia phonophobia worsens with activity multiple attacks lasting hours to days NV
diagnosis?
headache with fundoscopic showing papilledema
increased intracranial pressure
When should u image a pt with migraines
if he/she has red flags. Trauma, Sudden onset, Incr severity or freq, Old than 50, AIDS, neck stiff, Focal neuro
tx for migraines
triptans
ergotamine
NSAIDs
signs and sx
tension HA
bilateral bandlike distribution
no aggravation with activity
no NV
no photophobia / phonophobia
tx for tension HA`s
avoid what
caffeine and ergotamine drugs
signs and sx
cluster HA
unilateral
orbital / supraorbital / temporal
PACES AROUND - unable to find a comfortable position
contrast cluster vs migraines
migraines - wants to stay in one place
cluster - PACES AROUND
what are screening recs for lipids?
starting at 20yo
then ever 5 yrs after that
how do u screen for cholesterol?
fasting lipid panel (total, LDL, HDL, trig)
or
nonfasting total and HDL with subsequent fasting lipid panel if total is > 200 or HDL
Which class of drugs are best to lower LDL
Statins
which class of drugs are best to lower Triglycerides
which have no effect on triglycerides
nicotinic acids (niacin) fibrates (gemfibrozil)
bile acids
side effects
niacin
facial flushing
side effects
statins
muscle pain
side effects
bile acids
constipation
decreased absorption of other drugs
contraindications
niacin
gout
DM
contraindications
fibrates
severe kidney or liver disease
bucket-handle fracture of long bones in children
abuse