Families - Distinguishing Characteristics Flashcards
1
Q
- Latent infections
- Non-defective viruses have gag, pol, env genes
- Replication involves enzymes (RT, IN)
- Oncogenic viruses can be acute transforming (v-onc +) or slow/chronic (v-onc -)
- High mutation frequency
A
Retroviridae
2
Q
- Bullet shaped
- Encodes 5 proteins (L, G, N, P, M)
- 6 genera, 4 infect animals (Ephemerovirus, Lyssavirus, Vesiculovirus are most important)
A
Rhabdoviridae
3
Q
- Virions appear smooth and round in EM
- Genome has VPg
- Rapid cell death w/ CPE
- 29 genera w/ varying stability at low pH
A
Picornaviridae
4
Q
- Pleomorphic
- Nucleocapsid is “herringbone-shaped”
- May have HN, HA or G protein and NP
- Formation of syncytium
A
Paramyxoviridae
5
Q
- Segmented genome (variations in genera)
- Nearly spherical shaped
- Genetic reassortment (antigenic shift) between viruses within a genus or serogroup
- Genome has 10-12 segments
A
Reoviridae
6
Q
- Pleomorphic, spherical or filamentous
- Genome has 6-8 segments
- Classification of genera based on nucleoprotein and matrix proteins
- Classification of subtypes based on envelope proteins
- Undergo genetic reassortment (shift) or antigenic drift (mutations)
A
Orthomyxoviridae
7
Q
- Club-shaped spikes
- Nucleocapsid shape can be helical or tubular (donut-shaped)
- Two genera
A
Coronaviridae
8
Q
- Genomic RNA is infectious
- Produce persistent infections
- Only one genus
A
Arteriviridae
9
Q
- Envelope does not contain matrix protein
- Segmented (3)
- Bud into Golgi vesicles
- Generally cytocidal
- Undergo genetic reassortment (shift)
- 4 Genera
A
Bunyaviridae
10
Q
- 32 cup-shaped depressions
- Genomic RNA is infectious
A
Caliciviridae
11
Q
- Hexagonal shaped
- Segmented (2)
A
Birnaviridae
12
Q
- Cause persistent infection of neurons
A
Bornaviridae
13
Q
- 5-6 pointed starts on surface
A
Astroviridae
