Familial Breast Cancer Flashcards
1
Q
What proportion of breast cancers are due to an inherited fault in one of the breast cancer genes?
A
5% (1 in 20)
2
Q
What does “high risk” mean in terms of developing breast cancer?
A
The individual has a 30% or higher chance of developing breast cancer in their lifetime
3
Q
What does “moderate risk” mean in terms of developing breast cancer?
A
Risk lies between 17% and 30%
4
Q
What is the population risk of developing breast cancer?
A
Less than 17%
5
Q
How is the BRCA gene mutations inherited?
A
Autosomal dominant pattern
6
Q
Which chromosome is the BRCA1 gene located on?
A
Chromosome 17
7
Q
Which chromosome is the BRCA2 gene located on?
A
Chromosome 13
8
Q
By how much does the use of prophylactic mastectomy reduce the risk of breast cancer?
A
By 90%
