Factors Influencing drug Elimination | Uptake Mechanism, Substrates, Inhibitors | Acid-peptic Disease Drugs

Question 1

Factors Influencing Drug Elimination

Answer 1

• Sex
• Age
• Slow/Fast Acetylations
• Liver/Kidney diseases
• High or Low Doses
• Inhibitors/Inducers of CYP450 enzymes
• Genetic polymorphism

Question 2

Drugs used in Acid-Peptic disease

Answer 2

The following ways we can control acid-peptic diseases:
- Prostaglandin inhibitors [Misoprostol]
- Gastrin receptor stimulus inhibition [no current medication]
- H2 histamine antagonists [Cimetidine, Ranitidine]
- Direct Proton Pump Inhibitors [Omeprazole and other azoles | Blocks K+/H+ exchanger on gastric lumen]
- Gel like coverings for Ulcers [Sucralfate, Bismuth Subsalicylate]
- Antacids