Factors affecting toxicity Flashcards
1
Q
Which factors affect the disposition and toxicity of a foreign compound?
A
Chemical factors:
* Lipophilicity
* Size
* Structure
* pKa
* Ionization
* Chirality
Biological factors:
* Species, strain
* Sex
* Genetic factors
* Disease and pathological conditions
* Hormonal influences
* Age
* Stress
* Diet
* Tissue and organ specificity
* Dose
* Enzyme induction and inhibition
