Factor 11 Deficiency

Question 1

What is the inheritance of F11 deficiency?

Answer 1

Autosomal dominant or recessive

Question 2

What is the incidence of F11 deficiency?

Answer 2

Uncommon
1/ million in non Jewish population

Question 3

What are the symptoms of F11 deficiency?

Answer 3

Spontaneous bleeding is rare even with low factor levels
Patients are at risk of bleeding after surgery
F11 levels show poor correlation with symptoms

Question 4

What are the risks in pregnancy to mother and baby in F11 deficiency?

Answer 4

*F11 doesn’t increase during pregnancy
*Levels should be checked:
At booking/ 3rd trimester/ prior to invasive procedures
* women are at increased risk of PPH especially blood group O
* NO special precautions for the baby are required for delivery.