Eyelids Flashcards

1
Q

Layers of the eyelid (anterior to posterior)

A

Skin
Orbicularis muscle
Tarsal plate (fibrous)
Levator muscle
Muller muscle

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2
Q

Lamellae of the eyelids

A

Anatomically divided into 2 lamellae by the Gray line (outermost margin of the Orbicularis muscle)

  • Anterior lamella contains: skin and orbicularis
  • Posterior lamella contains: tarsal plate and conjunctiva
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3
Q

Landmarks of upper vs lower lid

A

Normally, the upper lid is 2mm below the superior limbus and the lower lid is at the level of the inferior limbus

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4
Q

What forms the tarsal plates?

A

The orbital septum

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5
Q

What maintains the shape of the eyelids?

A

The tarsal plates

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6
Q

How can depth of an eyelid laceration be catagorised?

A

Layer of preaponeurotic fat pads just posterior to the orbital septum

If the fat pads are visible then it is a deep laceration involving the posterior lamella

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7
Q

What landmarks differentiates orbital vs pre-orbital cellulitis

A

The orbital septum

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8
Q

Muscles which cause retraction of eyelid

A
  1. The levator innervated by CN3
  2. Frontalis (muscle of facial expression) innervated by CN7
  3. Muller’s muscle under sympathetic innervation
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9
Q

Main muscle of eyelid closure?

A

Orbicularis oculi innervated by CN7

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10
Q

What muscles has an important role in the lacrimal pump mechanism

A

Orbicularis oculi - its action guides the flow of tears across the ocular surface

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11
Q

Blink reflex

A

Afferent Limb (3 inputs paths)
* Corneal stimulus via CNV1
* Light stimulus via CN2
* Auditory stimulus via CN8

Efferent limb (1 effector path)
Via CN7 to the Orbicularis oculi muscle, which controls lid closure

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12
Q

What is Bell’s phenomenon?

A

Normal physiological finding where the globe rotates up and out during forced lid closure

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13
Q

Poor Bell’s phenomenon?

A

Is a risk factor for lagophthalmos

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14
Q

What are the Canthal tendons?

A
  • The canthal tendons keep the eyelid structure stable
  • 2 in each orbit: medial and a lateral
  • Attach to the tarsus of the upper and lower eyelids
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15
Q

Anatomical location of the lacrimal sac?

A

The lacrimal sac lies between the limbs of the medial canthal tendon

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16
Q

What is the palpebral fissure?

A

The gap between the upper and lower eyelid margins.

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17
Q

Thyroid eye disease and the eyelid

A

Retraction
Muller contraction

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18
Q

Horner syndrome and the eyelid

A

Ptosis
Muller relaxation

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19
Q

CN7 palsy and the eyelid

A

Lagophthalmos due to Orbicularis spasm

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20
Q

CN3 palsy and the eyelid

A

Ptosis
Levator relaxation

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21
Q

What is Lagophthalmos?
Why is it dangerous?

A

Inability to fully close the eyelids (palpebral fissure)

Leads to exposure keratopathy, which can be sight-threatening.

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22
Q

Types of lid reconstruction

A
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23
Q

Can both lamellae be repaired with grafts?

A

No because there would be no blood supply

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24
Q

How is the anterior lamella reconstructed?

A

Anterior advancement → incise and stretch tissue over the laceration
Transposition → move tissue from the other lid
Rotation → rotated skin from the cheek
Glabella → rotated diamond-shaped forehead skin

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25
Q

How is the posterior lamella reconstructed?

A

Hughs Flap → flap taken from the upper lid
Free tarsal graft from the fellow eye → tissue taken from the other eye

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26
Q

In a full-thickness laceration of the lid, which lamella is reconstructed first?

A

The posterior lamella is repaired before the anterior lamella

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27
Q

Blepharitis

A

Chronic inflammation of the eyelid of any cause.

Typically associated with Staphylococcus aureus infection.

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28
Q

Classification of Blepharitis

A

Anterior - Affects the base of the eyelashes
2 further subtypes:
* Seborrhoeic (excessive secretions)
* Staphylococcal (direct infection)

Posterior - Affects the Meibomian glands

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29
Q

Does anterior or posterior blepharitis have a better response to treatment?

A

Anterior, because it occurs at the surface level.

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30
Q

Blepharitis presentation

A

Bilateral crusting of the lids and lashes
Foamy tear film and meibomian cysts are seen specifically with posterior blepharitis.
The lashes can appear normal in posterior blepharitis

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31
Q

Unilateral blepharitis must be investigated for what?

A

Sebaceous cell carcinoma!

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32
Q

Atopic dermatitis is associated with what type of blepharitis

A

Staphylococcal

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33
Q

Seborrheic dermatitis is associated with what type of blepharitis

A

Seborrheic

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34
Q

Acne rosacea is associated with what type of blepharitis

A

Posterior

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35
Q

Management of blepharitis

A

Lid hygiene
Warm compress
Topical lubrication and tetracyclines

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36
Q

How do tetracyclines treat blepharitis?

A

limit fatty acid production which can decrease the inflammatory secretions

37
Q

Meibomian Gland Dysfunction

A

chronic disorder of the meibomian glands that overlaps with posterior blepharitis. It is characterised by duct obstruction and abnormal glandular secretions, which result in a characteristically foamy tear film

38
Q

Pathology of MGD

A

Secretion of the meibomian oil is obstructed → stagnation within glands → inflammation →staphylococcal colonisation → chronic inflammation and scarring

39
Q

Function of meibomian glands

A

Secrete a lipid layer which contributes to the tear film.

Functions of this layer is to help keep the tear film stable

40
Q

What is Meibomianitis?

A

Type of MGD where inflammation is marked

It is associated with acne rosacea and worse in the mornings with thick secretions and duct inflammation

41
Q

Presentation of MGD

A

Foamy tear film
Crusty eyelashes
Gritty irritated eyes

42
Q

Investigations for MGD

A
  • Tear film breakup time of <5 seconds is a sign of tear film instability
  • Fluorescein staining of the cornea shows corneal epithelial damage
43
Q

Management of MGD

A

Determined by clinical classification

44
Q

Untreated MGD can lead to?

A

MG cysts, trichiasis, blepharitis, and keratitis

45
Q

What is Trichiasis?

A

Trichiasis is the inward misdirection of the eyelashes. This can lead to corneal irritation and ulceration.

46
Q

Distichiasis

A

A congenital abnormality where there are 2 rows of eyelashes. Can be associated with Meige syndrome

47
Q

Acquired metaplastic lashes

A

Abnormally positioned lashes due to inflammation such as meibomitis and scarring

48
Q

Pseudotrichiasis

A

Inwardly projecting lashes due to entropion

49
Q

Types of Trichiasis?

A

Distichiasis
Acquired metaplastic lashes
Pseudotrichiasis

50
Q

Management of Trichiasis

A

Epilation - Recurrence is common so this is a temporising measure
Lash destruction by electrolysis/laser/cryotherapy - typically used when there is only a limited collection of abnormal lashes. Scarring and inflammation can be worsened.
Surgery - A pentagon excision can be used to remove focal groups of lashes.

51
Q

How are benign lid lumps classified?

A

Based on location: anterior or posterior lamella

52
Q

Hordeolum (stye)

A

A painful lid abscess caused by Staphylococcus infection.

53
Q

Hordeolum classification

A

External (anterior lamella): abscess of Zeis or Moll glands

Internal (posterior lamella): abscess of Meibomian glands

54
Q

Presentation of hordeolum

A

Painful nodule
Commonly affects the upper eyelid
Diagnosis is clinical

55
Q

Management of hordeolum

A

Hot compress
Oral antibiotics

56
Q

Key difference between Hordeolum vs chalazion

A

chalazion is a painless nodule

57
Q

Pathology of Chalazion

A

Obstruction of Meibomian or Zeis glands leads to sterile lymphogranuloma formation

58
Q

Presentation of chalazion

A

Painless upper eyelid nodule

59
Q

Management of chalazion

A

Hot compress is the only management that is usually required
Surgical incision and curettage is an option but rarely needed

60
Q

Anterior Lamella Cysts

A

Cyst of Moll and Cyst of Zeis are chronic benign anterior lamella cysts.

They are often self-limiting but can be excised or treated with diathermy

61
Q

Compare a cyst of Moll vs Zeis

A

Cyst of Moll - chronic translucent cyst arising from blockage of Moll glands

Cyst of Zeis - chronic non-translucent cysts arising from blockage of Zeis glands

62
Q

commonest cancer in ophthalmology

A

Basal Cell Carcinoma

63
Q

Basal Cell Carcinoma features

A
  • Most commonly occurs on lower lid of eye and upper lip of the mouth
  • It is a slow-growing lesion and does not typically spread
  • The lesion is pearly white with associated telangiectasia
64
Q

BCC management

A

Surgical resection
Mohs Micrographic surgery can for used in high-risk cases where the lesion margins are uncertain

65
Q

What is Vismodegib?

A

Vismodegib is a medication approved for non-resectable cases and works through the Hedgehog pathway.

BCC is associated with Ptch/Smo gene mutation in the Hedgehog pathway

66
Q

Squamous Cell Carcinoma is associated with what two populations?

A

HPV and immunocompromise

67
Q

Pathology of SCC

A

Aggressive and spreads via lymphatics
Histology shows epidermal proliferation, atypical keratinocytes, and squamous eddies

68
Q

Management of SCC

A

Surgical excision, radiotherapy, chemotherapy

69
Q

Melanoma pathology

A
  • Melanoma is not always pigmented.
  • Most likely to arise from the choroid inside the eye (highest concentration of melanin)
  • Spreads to the liver
  • Breslow thickness is the prognostic indicator
70
Q

Melanoma management

A

Surgical excision, radiotherapy, chemotherapy

71
Q

What is vemurafenib

A

Vemurafenib is a kinase inhibitor with FDA approval for unresectable melanomas

72
Q

Sebaceous Gland Carcinoma arise from?

A

Meibomian and Zeis glands

73
Q

Pathology of Sebaceous gland carcinoma

A

Can be misdiagnosed as unilateral blepharitis.
Spreads to lymph nodes and viscera
Associated with Muir Torre syndrome

74
Q

Management of Sebaceous gland carcinoma

A

Surgical excision, radiotherapy, chemotherapy
Prognosis is poor

75
Q

Entropion and ectropion most commonly affect which lid?

A

lower eyelids

76
Q

Ptosis most commonly affects which lid?

A

upper eyelids

77
Q

Ectropion

A

Outwardly pulled eyelid. It can stop the eyes from closing properly (lagophthalmos).

This can compromise the tear film and cause ocular surface irritation.

78
Q

Types of ectropion

A
79
Q

Most common type of ectropion

A

Involutional - Caused by horizontal lid laxity and often seen in the elderly

80
Q

Management of ectropion

A

Depends on the mechanism of ectropion:

Horizontal lid laxity → lateral tarsal strip
Vertical lid laxity → Diamond excision
Cicatrix → skin gaining procedures such as grafts and flaps

81
Q

Entropion

A

Entropion is an inwardly rolled eyelid. It can lead to corneal ulceration as the inwards turning eyelashes rub against the cornea whilst blinking.

82
Q

Types of Entropion

A
  1. Involutional (Commonest type) - caused by lower retractor weakness/dehiscence.
  2. Cicatricial - caused by shortening of the posterior lamella by vertical scarring.
    Most commonly caused by trachoma (upper lid)
83
Q

Management of Entropion

A

Depends on the mechanism of entropion

Retractor weakness → Everting sutures, transverse tarsotomy, or Jones procedure
Scarring → Membrane graft or posterior lamella reconstruction
Botox can be used to weaken overactive muscles

84
Q

Ptosis

A

An abnormally droopy upper eyelid. It can be congenital but is most commonly acquired.

85
Q

Types of ptosis

A

Involutional (commonest)
Neurogenic
Congenital Ptosis
Pseudoptosis

86
Q

Involutional ptosis

A

The most common type.
Caused by dehiscence of the levator palpebrae superioris from its attachment to the levator aponeurosis.
Risk is increased with age and after surgery.
Treatment → anterior levator advancement surgery

87
Q

Neurogenic ptosis

A

CN3 Palsy
* Loss of levator function leads to ptosis.
* Abnormalities in eye movements and a mydriatic pupil can also be seen.
* Spontaneous resolution is common so treatment (with frontalis suspension surgery) is typically delayed

Horner Syndrome
* Surgical management is with Levator resection (strengthens muscle) or Mullerectomy.

Myasthenia Gravis

88
Q

Congenital Ptosis

A

Isolated congenital ptosis
* Developmental myopathy of the LPS
* Typically unilateral, with an absent upper lid crease.
* Treatment depends on levator function:
* Poor function → frontalis suspension.
* Preserved function → anterior levator resection.

Blepharophimosis syndrome
* Characterised by a shortened horizontal palpebral fissure and telecanthus.
* AD inheritance

Marcus Gunn jaw-winking syndrome
* Characteristic elevation of the ptotic lid whilst chewing.
* Thought to be caused by developmental CN5 misdirection to the LPS

89
Q

Pseudoptosis

A

Pseudoptosis is a lid that appears droopy, but is actually within normal range when measured.

Blepharochalasis - abnormally elastic lid tissue leads to excess skin folds and oedema

Dermatochalasis - commonly seen in the elderly. Upper lid skin hangs and folds.

Brow ptosis
Frontalis dysfunction leads to lowering of the entire eyebrow region.