eye and phototransduction Flashcards

1
Q

briefly dscribe the evolution of the eye and visual activity

A

region of photosensitive cells -> depressed folded areas for directional sensitivity -> pinhole eye -> transparent humor in enclosed chamber -> distinct lens -> iris and cornea

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2
Q

what is visual acuity

A

measure of ability to distinguish 2 nearby points = dependent on density of photoreeptor packing

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3
Q

waht are some functions of photons other than visual processing

A

saccadic eye mvm, coordinating visual, somatic and auditory info, ajudtig mvm of head and eyes towards a stimulus

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4
Q

describe the pathway of light to reaech photoreceptors

A

travle across transparent retina (displaced portion of the CNS) before reached photoreeptor layer

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5
Q

why is the location of photoreceptor layer importnat

A

high regeneration and metabolic needs and need to be near blood

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6
Q

what are the 2 types of photoreceptors

A
rods = detect amount of light 
cones = perception of colour
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7
Q

describe the outer segment, innter segment and terminal of rods and cones

A

outer = region of phototransduction = falttened organelles. rods = membrane disks and cones have infolding
inner segment = nucleus and mitochondria
terminal = connected by axon-like process

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8
Q

what is scotopic and photopic vision

A
scotopic = night 
photopic = day
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9
Q

rod or cones are better with sptial and temporal resolution

A

cones are better

rods can detect dim lights tho

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10
Q

what is the fovea and is its structure

A

pinhead sized depression where cells other than cones are pushed out the way
high resolution = 1:1 ratio b/cones and ganglion cells

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11
Q

what are the 3 elements of the periphery

A

1 - higher ratio of rods to cones
2 - convergence of more photoreceptors
3 - more sensitive to light (night vision)

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12
Q

what is rhodopsin

A

light receptor molecule GPCR tightly packed in disk membranes and absorbes photons. there aew 10 billion rhodopsin molecules in a single rod

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13
Q

what are the 2 components of rhodopsin

A
retinal = deriviative of vit A
opsin = polypeptide with 7 transdoms
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14
Q

what happens when the all trans isomer of retinal activates opsin

A

opsin signals to heterotrimeric g protein transducing and intiriates 2nd messenger cgmp cascade

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15
Q

1 opsin can activate waht ….

A

enough signal amplification that 1 photon can produce 1 mV hyperpolarisaiton

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16
Q

opsin can activate …

A

enough signal amplification so that 1 photon produce 1mv hyperpolarisation

17
Q

what are the 3 types of cones

A

short = blue
medium = green
long = red
they ahve varying opsins

18
Q

what is colour [erception derived from

A

the overlapping but distinct responses

19
Q

what does the absorption of light by 11-cis retinal cause

A

a rotation around the doube bond to form more stable all trans retinal and a confromational change in the opsin

20
Q

what does variation of opsin in rodsdo

A

permits variation of spectral activity

21
Q

what can lead to colourblindness

A

recombination = hybrid/loss/duplcation of genes

22
Q

describe mechanism of the dark current

A

inwardly directed NA and outward K+ for depolarisation and darkness

23
Q

what happens to polarisation in light

A

photos close cation channels but K remains open = hyperpolarisation = light

24
Q

describe the info flow of neurons in the retina

A

photoreceptors (rods + cones) -> bipolar cells -> retinal ganglion cells

25
Q

what types of interneurons are there in the retina and what are they for

A

horizontal and amacrine cells for lateral interactions

26
Q

waht is the computational task of the retina

A

= to form sensitive and economical neural representation of the light image

27
Q

what preserves connections in photoreceptors

A

electrical or glutamatergic synapses

28
Q

what causes sign-inverting connections

A

gabaergic, glycinergic or glutamatergic synapses

29
Q

how do rods feed into the circuitary

A

via A2 amacrine cells