extras

Question 1

Migraine headache occurs via

Answer 1

intracranial vasoconstriction and extracranial vasodilation. This results in cerebral hypoxia and may be responsible for the neurologic defects that characterize the aura

Question 2

The pain associated with migraine can occur from the

Answer 2

rigeminal complex, which supplies the head and face region via cranial nerve V. Surrounding the large cerebral vessels, peal vessels, large venous sinuses, and dura mater is a plexus of largely unmyelinated fibers that arise from the ophthalmic division of the trigeminal ganlion and the upper cervical dorsal roots. The stimulation of these vessels cause the pain associated with migraine via the release of substance P and calcitonin gene-related peptide when the trigeminal ganglion is stimulated. Migraineurs may have a sensitization to the mechanoreceptors in these structures enhancing the responses to mechanical stimuli and can result in allodynia (painful response to non-noxious stimuli).[3]

Question 3

Cortical spreading depression is a mechanism that starts with

Answer 3

tarts with a small excitatory response that begins to spread through the brain and then causes a suppression of electroencephalographic (EEG) activity that moves through the cortex and can disturb the extracellular environment