Extras Flashcards
1
Q
Southern blot
A
DNA
USED FOR TRIPLET REPEAT EXPANSION, large deletion, duplication.
2
Q
When finding out about a child’s genetics, what is the key info needed?
A
age of onset of condition
3
Q
Male sperm older why bad
A
Increase point mutations–>increase AR and AD
Increase cancer in offspring
compare with women where older age –>aneuploidy
4
Q
Northern blot
A
for RNA
5
Q
Western blot
A
for protein labelled Ab
6
Q
What is a reciprocal translocation
A
exchange of genetic material with non homologous chromosome
7
Q
Robertsonian translocation
A
break at or near centromeres of two acrocentric chromosomes
- balanced if no genetic material lost- NOT detected on microarray
- unbalanced associated with infertility/azoospermia/miscarriages
