Extranuclear Inheritance (2)

Question 1

3 mitochondrial DNA defects

Answer 1

MERRF
LHON
KSS

Question 2

MERFF

Answer 2

Myoclonic epilepsy and ragged red fiber disease

• maternal transmission
•symptoms:
Ataxia, deafness, dementia, seizures

Question 3

LHON

Answer 3

Lebers hereditary optic neuropathy

Maternal inheritance
Symptoms: sudden bilateral blindness by late 20’s

Question 4

KSS

Answer 4

Kearns-Sayre syndrome

Symptoms: blind, deaf, heart conditions

Question 5

Heteroplasmy

Answer 5

Variation of DNA within organelles such as mitochondria and chloroplasts within the same cell.