Extra Questions from Study Materials Flashcards
Mnemonic for potency of glucocorticoids
“Cold Hands Palpate My Dead Body” (least to most potent)
Cortisone -> hydrocortisone -> prednisone/prednisolone –> methylprednisolone –> dexamethasone –> betamethasone
Thyroid and adrenal disorders – what do you replete in what order
Glucocorticoid then mineralcorticoid and last thyroid replacement
T4 should not be administered until adrenal function, including ACTH reserve, have been evaluated and either found to be normal or treated. In patients with coexisting hypothyroidism and hypoadrenalism, treatment of hypothyroidism alone may increase the clearance of the little cortisol produced, increasing the severity of the cortisol deficiency
Differential of tall and primary amenorrhea
Complete AIS – no uterus
Complete 46, XY GD – (DAX dup) - uterus
Most common malignancy associated with IVF?
- Borderline
Hypercarotenemia associated with what HPO axis anomaly?
Hypo hypo (anorexia)
Also hypothyroidism, diabetes
Causes of falsely elevated cortisol
Obesity
Late night salivary cortisol test: licorice, chewing tobacco, smoking, shift workers, night owls
Dexa suppression test: OCPs (increase CBG and assay measures total cortisol), anticonvulsant medication (accelerates metabolism of dexamethasone)
Normal BMI and PCOS, best treatment?
Clomid, metformin, or both
Clomid
Most likely to have heterophilic antibodies?
Vet tech
Kappa statistic
Measure of agreement between 2 observers (-1.0 to +1.0). Perfect agreement = 1.0 If agreement is what would be expected by chance alone then = 0. If degree of agreement less than what would be expected by chance then < 0.