Extra Qs

Question 1

What are the 2 most important risk factors for periodontitis

Answer 1

age and plaque

Question 2

What salivary components are amphipathic, what are secreted by plasma cells, and what are glycosylated proteins

Answer 2

• amphipathic = AMP
• Plasma cells = IgA
• Glycosylated = mucin

Question 3

What pathogen commonly affects burns patients

Answer 3

-p aeruginosa

Question 4

Where are neutrophils stored

Answer 4

Blood and bone marrow

Question 5

what pathogen is double stranded RNA unique to

Answer 5

a virus

Question 6

What class of antibody is abundant in the primary phase of immune reponses?

Answer 6

IgM

Question 7

What is the structure of IgA antibodies secreted with the saliva

Answer 7

Dimeric

Question 8

What class of antibody predominantly crosses the placenta to provide protection to the developing foetus?

Answer 8

IgG

Question 9

What PEM stands for

Answer 9

protein energy malnutrition

Question 10

How are CD8 T cells activated

Answer 10

• Directly by antigen presenting cells with class I MHC

- Indirectly by APC - Th1 - CD4 - CD8

Question 11

What is Hypergammaglobulinemia

Answer 11

excessive antibody production

Question 12

Which organ of the body drives an acute phase response

Answer 12

Liver

Question 13

The elevation of which cytokines is responsible for septic shock

Answer 13

TNF-a, IL 1, IL6

Question 14

what 2 enzymes do CD8 cells contain and their role

Answer 14

• Perforin pierces the cell wall

- Granzyme induces apoptosis in the virus infected cell

Question 15

Which cellular structure is readily modified by Streptococcus pneumoniae in order for it evade detection by host immunity

Answer 15

Capsular polysaccharide

Question 16

Which immune cell are the targets for Epstein-Barr virus infection

Answer 16

B cell

Question 17

Mutations in the adenosine deaminase gene are associated with which immunodeficiency

Answer 17

severe combined immunodeficiency (SCID)

Question 18

Nucleoside analogs are effective in treatment of HIV as they target which aspect of the viruses lifecycle

Answer 18

Reverse transcription of viral RNA to cDNA

Question 19

Rheumatoid factor is an autoantibody against which class of antibody

Answer 19

IgG

Question 20

Carriers of which HLA allele have a genetic predisposition for coeliac disease. What protein are they hypersensitive to

Answer 20

HLA DQ2

alpha gliadin in gluten

Question 21

High doses of which drug can cause secondary gout by inhibiting uric acid excretion

Answer 21

Aspirin

Question 22

C-type lectin receptors paly a key role in the detection and clearance of which pathogens

Answer 22

Fungi

Question 23

What does the 6 in 1 vaccine for <1 year olds protect you against

Answer 23

Diphtheria
Hepatitis B
Haemophilus influenza b (Hib)
Polio
Tetanus
Whooping cough (pertussis)

Question 24

What cells are involved in hypercute, acute, chronic rejection, and graft v host reaction

Answer 24

1. Pre-existing host anti HLA antibodies
2. Host T cells
3. Immune complexes in donor tissue
4. Donor T cells

Question 25

Which technique can be used by a haematologist to diagnose a primary immunodeficiency disorder

Answer 25

Flow cytometry

Question 26

Fill in the gaps: Antibodies produced by conventional immunisation have [no/substantial ] variability between preparations and their supply is [Limitless/limited]. Monoclonal antibodies have [ ]variability between preparations and their supply is [Limitless/ limited] . Recombinant antibodies have [ ] variability between preparations and their supply is [Limitless/Limited]. Which is less likely to be recognised as self

Answer 26

Antibodies produced by conventional immunisation have [substantial] variability between preparations and their supply is [Limitled] . Monoclonal antibodies have [No variability] between preparations and their supply is [Limitless] . Recombinant antibodies have [no] variability between preparations and their supply is [Limitless] -Recombinant