Extra Martin Skeletal Muscle Path

Question 1

2 main responses of peripheral nerves to injury?

Answer 1

Segmental demyelination

Atonal demyelination

Question 2

2 principle pathological processes seen in muscle?

Answer 2

Enervation atrophy

Myopathy

Question 3

What is onion bulb on histo?

Answer 3

Concentric layers of Schwann cytoplasm

Question 4

What is a traumatic neuroma?

Answer 4

When an axon is trying to reinnervate its target and it doesn’t make it and creates a nodule basically.

Question 5

Two types of denervated fibers?

Answer 5

Angulated and target

Question 6

What determines the fiber type of a muscle fiber?

Answer 6

The motor neuron

Question 7

If you were to stain for muscle fiber type in a normal muscle before denervation and after what would it look like?

Answer 7

Normal checkerboard appearance.

Type grouping because an unaffected motor unit has innervated the fibers and all those fibers are the same type.

Question 8

4 main pathologic reactions of a muscle fiber?

Answer 8

Segmental necrosis
Vacuolization
Regeneration
Hypertrophy and fiber splitting