Extra Flashcards
1
Q
4 C’s of C diff infection
Treatment
A
Clindamycin
Cephalosporin
Ciprofloxacin
Co-amoxiclav
Clindamycin = 23s inhibitor of 50s subunit.
Cephalosporin = b-lactam - inhibit cell wall synthesis.
Ciprofloxacin = inhibit topoisomerase ii (DNA gyrase) preventing supercoiling.
Co-amoxiclav = inhibits beta lactamase to enhance beta lactams.
2
Q
Hepatocyte Zones
A
Zone 1: O2 rich, viral hepatitis infection site, oxidative liver function
Zone 2: mix
Zone 3: O2 deprived, ischaemia (in alcoholics)
hepatocyte = functional cell of liver.
Arranged in lobules (hexagonal units), bile canaliculi in between lobules..
3
Q
Portal Vein
A
4
Q
Excess laxative use
A
Melanosis Coli: pigmentation of large intestine (presence of lipofuscin).
