Experimental Procedures Flashcards

1
Q

(trans)dermal application

A
  • drug in solution applied directly on (shaven) skin or mucous membrane
  • not accurate, variability in skin penetration &risk of rubbing, licking
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2
Q

enteral administration of compounds

A
  • oral administration to the gastrointestinal tract
  • e.g. through food & drinking water
  • not possible with unpalatable substances
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3
Q

Types of injections

A
  • intracutaneous (intradermal)
  • subcutaneous
  • intramuscular
  • intraperitoneal
  • intravenous
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4
Q

Attention to features of injection techniques:

A
  • width (gauge) of needle
  • sterility
  • max volume of injection
  • air bubbles
  • injected fluids must be brought to room temp (cold fluids are painful)
  • IP inj risk of damaging internal organs
  • high or low pH fluids should be diluted in saline
  • large amounts of fluid should be adminstered IV, IP or orally
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5
Q

Maximum volume of blood to be collected

A
  • total volume is constant at ca. 8% of body weight for most animals
  • > 10% of blood volume sample weight can lead to hypovolaemia and cardiovascular failure (shock)
  • rule of thumb: max 8ml/kg of bodyweight
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6
Q

Suturing techniques

A
  • interrupted stitch vs continuous stitch (continuous is faster but not recommended for larger wounds as rupture can result in the entire stitch unravelling)
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