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Bacterial Exotoxins > Exotoxins > Flashcards

Exotoxins Flashcards

0
Q

Exotoxin A - pseudomonas

Mechanism of action

A

Adp ribosylate EF-2

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1
Q

Diphtheria toxin

Organism

Mechanism of action

A

Adp ribosylate EF-2

C diphtheriae

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2
Q

Shiga toxin

Organism

Mechanism of action

A

Bind to and inactivate 60S ribosomal subunit

Shigella

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3
Q

Shiga-like toxin

Organism

Mechanism of action

A

Bind to and inactivate 60S ribosomal subunit

EHEC

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4
Q

Heat labile toxin (LT)

Organism

Mechanism of action

A

Activates AC –> increased cAMP
Leads to Cl secretion into gut and water efflux

Labile in the air, stable on the ground

ETEC

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5
Q

Heat stable toxin (ST)

Organism

Mechanism of action

A

ETEC

Over activate GC –> decreased reabsorption of NaCl and water in the gut

Labile in the air, stable on the ground

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6
Q

Edema factor

Organism

Mechanism of action

A

Bacillus anthracis

Mimics adenylate Cyclades

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7
Q

Cholera toxin

Organism

Mechanism of action

A

Vibrio cholerae

Permanently activates Gs, leading to increased cAMP
Leads to increased Cl secretion into gut, with water following

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8
Q

Pertussis toxin

Organism

Mechanism of action

A

Bordetella pertussis

Inactivated Gi, increasing cAMP
Impairs phagocyte function

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9
Q

Tetanospasmin

Organism

Mechanism of action

A

Cleaved synaptobrevin/sNARE, blocking vesicle formation and release of gABA and glycine

Clostridium tetani

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10
Q

Botulinum toxin

Organism

Mechanism of action

A

Cleaved synaptobrevin/SNARE, blocking vesicle formation and acetylcholine release

Clostridium botulinum

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11
Q

Alpha toxin

Organism

Mechanism of action

A

Clostridium perfringens

Phospholipase that degrades tissue and cell membranes
Degradation of Plc leads to myonecrosis (gas gangrene) and hemolysis (double zone of hemolysis on blood agar)

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12
Q

Streptolysin O

Organism

Mechanism of action

A

Strep pyogenes

Protein that degrades cell membranes

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13
Q

TSST-1

Organism

Mechanism of action

A

Staph aureus

Superantigen leads to polyclonal T cell activation and release of iL-2 and iFN-gamma

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14
Q

Exotoxin A - strep

Organism

Mechanism of action

A

Strep pyogenes

Superantigen leads to polyclonal T cell activation and release of iL-2 and iFN-gamma

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15
Q

Toxin A c diff

Name

Mechanism of action

A

Enterotoxin

Binds to brush border of gut, alters fluid secretion, leading to watery diarrhea

16
Q

Toxin b c diff

Name

Mechanism of action

A

Cytotoxin

Depolymerizes actin, leading to necrosis of epithelial cells and pseudomembrane formation

Bacterial Exotoxins (1 decks)

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