Exercise Physiology in Ageing Flashcards
Define what count as unhealthy years of living
LIving with chronic conditions
Are we targeting the source of chonic conditions?
No, we are targeting different diseases as they arise
We are not targetting the slowing of ageing itself
What conditions does ageing lead to?
Functional decline
Acute disease
Chronic disease
Define primary prevention
To prevent/stop disease from happening
Install in place interventions to prevent things before they begin
Define secondary prevention
Person has risk factors for disease = try to prevent it progressing
Define tertiary prevention
Person has full-blown condition = want to prevent comorbidities from occurring
Can ageing be modulated?
Yes
Targetting longevity pathways
Geroprotector drugs/supplements
What is the difference between PA and exercise?
PA = any bodily movement produced by contracting skeletal muscle
This increases energy expenditure above resting level
Exercise = subset of PA, planned structured and repetitive
Have a goal to improve or maintain physical fitness and health
How does physical inactivity drive the progression of disease?
Mainly by driving INFLAMMATION
Increases risk factors = hypertension, hyperglycemia, obesity etc
Any 3 risk factors = metabolic syndrome
Lading to T2D or atherosclerosis = premature death
How is cardiorespiratory fitness defined?
VO2 max = predictor of functional capacity
Maximum amount of oxygen that a person is capable of consuming during strenuous exercise
Is Fitness or PA more important?
Fitness is more important because to be relatively fit increases your mortality to similar levels of exceptionally fit people
Whereas to get a better mortality for PA, you must exponentially increase the PA done
What are METs and how do they correlate to mortality?
Metabolic equivalents
1 MET = the energy used when a person is resting or sitting still
Increased METs = decreased mortality
How does exercise help with macromolecular damage?
Upregulates antioxidants and enzyme activities that modulates DNA repair
How does exercise help with adaptation to stress?
How does exercise help with proteostasis?
