exercise obesity and performance enchancing drugs Flashcards
suggest some effects athletes might want a peformance enchancing drug to have on their body?
muscle production
RBC
increased air flow
anabolic steroids
used for buiding muscle mass
hormones
Stimulate the formation of RBCs or production of growth hormone needed for muscle growth
beta 2 agonist
Dilate the airways allowing more air into the lungs
hormone agonist
Chemicals which mask or change the action of another hormone
diuretics
Stimulate excess urination which athletes may use to eliminate traces of other drugs
blood doping
Blood transfusion to increase oxygen carrying capacity
stimulants
increase heart rate to make you more alert
what are hormones
they are chemical messengers released directly into the blood from the endocrine glands
the hormones produced by these glands are often made in inactive forms or packaged into secretory vesicles from the golgi
steroid hormones
Small lipid soluble molecules can freely move through the cell surface membrane
Once the hormone enters the cells it binds to the steroid receptors and forms a hormone-receptor complex
The hormone-receptor complex enters the nucleus and affects transcription
peptide hormones
Charged polar molecules bind to the cell surface receptor on the cell surface
Receptor proteins have a specific 3D tertiary structure giving them specific binding sites which are complementary to the hormone molecule
Due to this interaction, second messenger molecules inside the cytoplasm are activated and these directly or indirectly alter the gene
erythropoietin
secreted by the kidney
stimulates the stem cells in the bone marrow
increases the RBC count
they may want to inject EP to increase the amount of haemoglobin
describe how EPO leads to an increase in the production of RBC’s?
EPO binds to receptors on bone marrow stem cells and activates secondary messengers
Secondary messengers bind to the promoter region on DNA
Genes associated with red blood cells are activated
Proteins like haemoglobin are produced which permanently modify the structure and function of the cell
anabolic steroids
Testosterone is steroid hormone which is responsible for the development of the male sexual organs and secondary sexual characteristics
It binds to the androgen receptor on cells and increases anabolic reactions
It can pass through the cell surface meaning it is a steroid hormone
effects of using anabolic steroids
heart attack
high blood pressure
infertility
liver damage
increase aggression levels