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Antibiotics > Excreted Via > Flashcards

Excreted Via Flashcards

1
Q

Natural Penicillins

A

Renal (unchanged)

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2
Q

Penicillinase resistant penicillin

A

Renal

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3
Q

Aminopenicillins

A

Renal (unchanged in urine), need dose adjustment

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4
Q

Anti-pseudomonal penicillins

A

Renal (unchanged in urine), need dose adjustment

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5
Q

Penicillins + Beta lactamase inhibitors

A

Renal (unchanged for Co-amox and Sulbactam, metabolites + unchanged for Pip-Tazo), need dose adjustment

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6
Q

1st-5th gen cephalosporins except ceftriaxone

A

Renal

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7
Q

Ceftriaxone

A

Hepatic

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8
Q

Carbapnems

A

Renal (need dose adjustment: Imipenem + Clistatin), the rest also renal but don’t need to adjust

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9
Q

Aztreonam

A

Renal, need dose adjustment

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10
Q

Vancomycin

A

Renal, need dose adjustment

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11
Q

Tetracyclines

A

Renal (Tetracyclines), Unchanged in bile + urine (Doxycyline) and Liver for Minocycline

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12
Q

Tigecyclines

A

Hepatic (caution only, no need adjustment)

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13
Q

Aminoglycosides

A

Renal, needs dose adjustments

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14
Q

Macrolides

A

Hepatic (Erythromycin and Clarithromycin), Unchanged in feces (Azithromycin)

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15
Q

Clindamycin

A

Hepatic (caution)

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16
Q

Linezolid

A

Non-enzymatic oxidation to inactive metabolites, no adjustments needed

17
Q

Fluoroquinolones (Ciprofloxacin + Levofloxacin)

A

Renal, need dose adjustment

18
Q

Fluoroquinolones (Moxifloxacin)

A

Hepatic, need dose adjustments

19
Q

Sulfonamides

A

Renal, need dose adjustments

20
Q

Trimethoprim

A

Renal, need dose adjustments

21
Q

Co-trimoxazole

A

Renal, need dose adjustments

22
Q

Nitrofurantoin

A

Renal, no need dose adjust but stop if CrCL < 40mL/min

23
Q

Amophotericin B

A

Renal, no mention of dose adjustment although nephrotoxic

24
Q

5-Flucytosine

A

Renal, need dose adjustments

25
Q

Echinocandins

A

Excreted in urine and feces, non-renally cleared

26
Q

Azoles (Fluconazole)

A

Renal, needs dose adjustments

27
Q

Azoles (Posconazole, Itraconazole and Voriconazole)

A

P: Feces, I: Liver, V: Liver

28
Q

Clotrimazole and Miconazole

A

Absorption is low so not very applicable

29
Q

Nystatin (Not mentioned)

A

NIL

30
Q

Terbinafine

A

Avoid in severe renal and hepatic dysfunction

Antibiotics (2 decks)

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